Search Results - "van der Deure, Wendy M."

Organic Anion Transporter 1B1: An Important Factor in Hepatic Thyroid Hormone and Estrogen Transport and Metabolism by van der Deure, Wendy M, Friesema, Edith C. H, de Jong, Frank Jan, de Rijke, Yolanda B, de Jong, Frank H, Uitterlinden, André G, Breteler, Monique M. B, Peeters, Robin P, Visser, Theo J

“…Sulfation is an important pathway in the metabolism of thyroid hormone and estrogens. Sulfation of estrogens is reversible by estrogen sulfatase, but sulfation…”
Get full text

Molecular aspects of thyroid hormone transporters, including MCT8, MCT10, and OATPs, and the effects of genetic variation in these transporters by van der Deure, Wendy M, Peeters, Robin P, Visser, Theo J

“…Thyroid hormone is a pleiotropic hormone with widespread biological actions. For instance, adequate levels of thyroid hormone are critical for the development…”
Get full text

Influence of Enzalutamide on Cabazitaxel Pharmacokinetics: a Drug-Drug Interaction Study in Metastatic Castration-resistant Prostate Cancer (mCRPC) Patients by Belderbos, Bodine P S, Bins, Sander, van Leeuwen, Roelof W F, Oomen-de Hoop, Esther, van der Meer, Nelly, de Bruijn, Peter, Hamberg, Paul, Overkleeft, Esther N M, van der Deure, Wendy M, Lolkema, Martijn P, de Wit, Ronald, Mathijssen, Ron H J

“…In ongoing clinical research on metastatic castration-resistant prostate cancer (mCRPC) treatment, the potential enhanced efficacy of the combination of…”
Get full text

Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis by Meulenbelt, Ingrid, Min, Josine L., Bos, Steffan, Riyazi, Naghmeh, Houwing-Duistermaat, Jeanine J., van der Wijk, Henk-Jan, Kroon, Herman M., Nakajima, Masahiro, Ikegawa, Shiro, Uitterlinden, André G., van Meurs, Joyce B.J., van der Deure, Wendy M., Visser, Theo J., Seymour, Albert B., Lakenberg, Nico, van der Breggen, Ruud, Kremer, Dennis, van Duijn, Cornelia M., Kloppenburg, Margreet, Loughlin, John, Slagboom, P. Eline

“…Osteoarthritis [MIM 165720] is a common late-onset articular joint disease for which no pharmaceutical intervention is available to attenuate the cartilage…”
Get full text

Ranitidine and the incidence of hypersensitivity reactions to paclitaxel: A retrospective cohort study by Haine, Anouk I., Notenboom, Cornelia (Marije) A. W., Tan, Liong (Vincent) P., Ruiter, Rikje, Deure, Wendy M.

“…Paclitaxel is a commonly used chemotherapeutic agent. To minimize the risk of hypersensitivity reactions (HSRs), which occur in approximately 16–42% of…”
Get full text

Effect of Scalp Cooling on the Pharmacokinetics of Paclitaxel by van Doorn, Leni, van Rosmalen, Mandy M., van der Deure, Wendy M., Oomen-de Hoop, Esther, Porrazzo, Robert, Wijngaard, Sophie M., Boere, Ingrid A., Veenstra, Paola, Ibrahim, Eman, de Bruijn, Peter, Friberg, Lena E., Koolen, Stijn L. W., Mathijssen, Ron H. J., Jager, Agnes

“…Chemotherapy-induced alopecia (CIA), a side effect with high impact, can be prevented by cooling the scalp during the administration of some cytotoxic drugs…”
Get full text

Genetic variation in thyroid hormone pathway genes; polymorphisms in the TSH receptor and the iodothyronine deiodinases by Peeters, Robin P, van der Deure, Wendy M, Visser, Theo J

“…Serum thyroid parameters show substantial inter-individual variability, in which genetic variation is a major factor. Findings in patients with subclinical…”
Get full text

Thyroid Hormone Transport and Metabolism by Organic Anion Transporter 1C1 and Consequences of Genetic Variation by van der Deure, Wendy M, Hansen, Pia Skov, Peeters, Robin P, Kyvik, Kirsten Ohm, Friesema, Edith C. H, Hegedüs, Laszlo, Visser, Theo J

“…Organic anion transporting polypeptide (OATP) 1C1 has been characterized as a specific thyroid hormone transporter. Based on its expression in capillaries in…”
Get full text

A large-scale association analysis of 68 thyroid hormone pathway genes with serum TSH and FT4 levels by Medici, Marco, van der Deure, Wendy M, Verbiest, Michael, Vermeulen, Sita H, Hansen, Pia S, Kiemeney, Lambertus A, Hermus, Ad R M M, Breteler, Monique M, Hofman, Albert, Hegedüs, Laszlo, Kyvik, Kirsten Ohm, Heijer, Martin den, Uitterlinden, André G, Visser, Theo J, Peeters, Robin P

“…ObjectiveMinor variation in serum thyroid hormone (TH) levels can have important effects on various clinical endpoints. Although 45–65% of the inter-individual…”
Get full text

The effect of genetic variation in the type 1 deiodinase gene on the interindividual variation in serum thyroid hormone levels: an investigation in healthy Danish twins by Van Der Deure, Wendy M., Hansen, Pia Skov, Peeters, Robin P., Uitterlinden, André G., Fenger, Mogens, Kyvik, Kirsten Ohm, Hegedüs, Laszlo, Visser, Theo J.

“…Summary Introduction  Genetic factors have a considerable influence on serum thyroid hormone levels. The C785T and A1814G polymorphisms, located in the 3′…”
Get full text

Identification and consequences of polymorphisms in the thyroid hormone receptor alpha and beta genes by Sørensen, Helena Gásdal, van der Deure, Wendy M, Hansen, Pia Skov, Peeters, Robin P, Breteler, Monique M B, Kyvik, Kirsten Ohm, Sørensen, Thorkild I A, Hegedüs, Laszlo, Visser, Theo J

“…Genetic factors exert considerable influence on thyroid function variables. Single nucleotide polymorphisms (SNPs) in thyroid hormone pathway genes have been…”
Get more information

Genetic variation in thyroid hormone transporters by van der Deure, Wendy M., MD, Peeters, Robin P., MD, PhD, Visser, Theo J., PhD

“…Determination of the sequence of the human genome has led to a large expansion of research in this area. Several studies on single nucleotide polymorphisms,…”
Get full text

Tolerability and effectiveness of palbociclib in older women with metastatic breast cancer by Baltussen, Joosje C., Mooijaart, Simon P., Vulink, Annelie J.E., Houtsma, Danny, Van der Deure, Wendy M., Westerman, Elsbeth M., Oosterkamp, Hendrika M., Spierings, Leontine E.A.M.M., van den Bos, Frederiek, de Glas, Nienke A., Portielje, Johanneke E.A.

“…Purpose Palbociclib has become the standard of care for estrogen receptor-positive (ER+), human epidermal growth factor receptor 2 negative (HER2-) metastatic…”
Get full text

High free thyroxine levels are associated with QTc prolongation in males by van Noord, Charlotte, van der Deure, Wendy M, Sturkenboom, Miriam C J M, Straus, Sabine M J M, Hofman, Albert, Visser, Theo J, Kors, Jan A, Witteman, Jacqueline C M, Stricker, Bruno H Ch

“…The literature on the effect of excess thyroid hormone on ventricular repolarization is controversial. To study whether free thyroxine (T4) and TSH are…”
Get full text

Malignancy Presenting as Multiple Lesions in a Cirrhotic Liver: Not Always Hepatocellular Carcinoma by Van der Deure, Wendy M., Lugtenburg, Elly P.J., Dwarkasing, Roy S., Biermann, Katharina, Tjwa, Eric T.T.L.

Get full text

Effects of serum TSH and FT4 levels and the TSHR-Asp727Glu polymorphism on bone: the Rotterdam Study by Van Der Deure, Wendy M., Uitterlinden, André G., Hofman, Albert, Rivadeneira, Fernando, Pols, Huibert A. P., Peeters, Robin P., Visser, Theo J.

“…Summary Background  TSH and thyroid hormone may have independent effects on bone. In this study we investigated the association of TSH and free T4 (FT4) with…”
Get full text

The type 2 deiodinase Thr92Ala polymorphism is associated with increased bone turnover and decreased femoral neck bone mineral density by Heemstra, Karen A, Hoftijzer, Hendrieke, van der Deure, Wendy M, Peeters, Robin P, Hamdy, Neveen A, Pereira, Alberto, Corssmit, Eleonora P, Romijn, Johannes A, Visser, Theo J, Smit, Johannes W

“…The role of type 2 deiodinase (D2) in the human skeleton remains unclear. The D2 polymorphism Thr92Ala has been associated with lower enzymatic activity, which…”
Get full text

Polymorphisms in the brain-specific thyroid hormone transporter OATP1C1 are associated with fatigue and depression in hypothyroid patients by Van Der Deure, Wendy M., Appelhof, Bente C., Peeters, Robin P., Wiersinga, Wilmar M., Wekking, Ellie M., Huyser, Jochanan, Schene, Aart H., Tijssen, Jan G. P., Hoogendijk, Witte J. G., Visser, Theo J., Fliers, Eric

“…Summary Introduction  Some hypothyroid patients continue to have significant impairments in psychological well‐being, despite adequate treatment with…”
Get full text

Preliminary evidence that a functional polymorphism in type 1 deiodinase is associated with enhanced potentiation of the antidepressant effect of sertraline by triiodothyronine by Cooper-Kazaz, Rena, van der Deure, Wendy M, Medici, Marco, Visser, Theo J, Alkelai, Ana, Glaser, Benjamin, Peeters, Robin P, Lerer, Bernard

“…Abstract Background Triiodothyronine (T3) is used to potentiate the clinical effect of antidepressant drugs. Inter-individual differences in efficacy may be…”
Get full text

The Association of Polymorphisms in the Type 1 and 2 Deiodinase Genes with Circulating Thyroid Hormone Parameters and Atrophy of the Medial Temporal Lobe by de Jong, Frank Jan, Peeters, Robin P., den Heijer, Tom, van der Deure, Wendy M., Hofman, Albert, Uitterlinden, André G., Visser, Theo J., Breteler, Monique M. B.

“…Context: Thyroid function has been related to Alzheimer disease (AD) and neuroimaging markers thereof. Whether thyroid dysfunction contributes to or results…”
Get full text