Search Results - "van der Burg, Sjoerd H"

Monalizumab: inhibiting the novel immune checkpoint NKG2A by van Hall, Thorbald, André, Pascale, Horowitz, Amir, Ruan, Dan Fu, Borst, Linda, Zerbib, Robert, Narni-Mancinelli, Emilie, van der Burg, Sjoerd H., Vivier, Eric

“…The implementation of immune checkpoint inhibitors to the oncology clinic signified a new era in cancer treatment. After the first indication of melanoma, an…”
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Identification and manipulation of tumor associated macrophages in human cancers by Heusinkveld, Moniek, van der Burg, Sjoerd H

“…Evading immune destruction and tumor promoting inflammation are important hallmarks in the development of cancer. Macrophages are present in most human tumors…”
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Cross-presentation of a TAP-independent signal peptide induces CD8 T immunity to escaped cancers but necessitates anchor replacement by Marijt, Koen A., Griffioen, Lisa, Blijleven, Laura, van der Burg, Sjoerd. H., van Hall, Thorbald

“…Cancer cells frequently display defects in their antigen-processing pathway and thereby evade CD8 T cell immunity. We described a novel category of cancer…”
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Therapeutic cancer vaccines by Saxena, Mansi, van der Burg, Sjoerd H., Melief, Cornelis J. M., Bhardwaj, Nina

“…Therapeutic cancer vaccines have undergone a resurgence in the past decade. A better understanding of the breadth of tumour-associated antigens, the native…”
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Human papillomavirus (HPV) upregulates the cellular deubiquitinase UCHL1 to suppress the keratinocyte's innate immune response by Karim, Rezaul, Tummers, Bart, Meyers, Craig, Biryukov, Jennifer L, Alam, Samina, Backendorf, Claude, Jha, Veena, Offringa, Rienk, van Ommen, Gert-Jan B, Melief, Cornelis J M, Guardavaccaro, Daniele, Boer, Judith M, van der Burg, Sjoerd H

“…Persistent infection of basal keratinocytes with high-risk human papillomavirus (hrHPV) may cause cancer. Keratinocytes are equipped with different pattern…”
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Metabolic stress in cancer cells induces immune escape through a PI3K-dependent blockade of IFNγ receptor signaling by Marijt, Koen A, Sluijter, Marjolein, Blijleven, Laura, Tolmeijer, Sofie H, Scheeren, Ferenc A, van der Burg, Sjoerd H, van Hall, Thorbald

“…T-cell mediated immunotherapy brought clinical success for many cancer patients. Nonetheless, downregulation of MHC class I antigen presentation, frequently…”
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The NKG2A-HLA-E Axis as a Novel Checkpoint in the Tumor Microenvironment by Borst, Linda, van der Burg, Sjoerd H, van Hall, Thorbald

“…The success of checkpoint blockade therapy revolutionized cancer treatment. However, we need to increase the fraction of responding patients and overcome…”
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Human papillomavirus deregulates the response of a cellular network comprising of chemotactic and proinflammatory genes by Karim, Rezaul, Meyers, Craig, Backendorf, Claude, Ludigs, Kristina, Offringa, Rienk, van Ommen, Gert-Jan B, Melief, Cornelis J M, van der Burg, Sjoerd H, Boer, Judith M

“…Despite the presence of intracellular pathogen recognition receptors that allow infected cells to attract the immune system, undifferentiated keratinocytes…”
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Regulatory T Cell Depletion Using a CRISPR Fc-Optimized CD25 Antibody by van Elsas, Marit J., van der Schoot, Johan M. S., Bartels, Alexander, Steuten, Kas, van Dalen, Duco, Wijfjes, Zacharias, Figdor, Carl G., van Hall, Thorbald, van der Burg, Sjoerd H., Verdoes, Martijn, Scheeren, Ferenc A.

“…Regulatory T cells (Tregs) are major drivers behind immunosuppressive mechanisms and present a major hurdle for cancer therapy. Tregs are characterized by a…”
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Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy by Hanoteau, Aurelie, Newton, Jared M, Krupar, Rosemarie, Huang, Chen, Liu, Hsuan-Chen, Gaspero, Angelina, Gartrell, Robyn D, Saenger, Yvonne M, Hart, Thomas D, Santegoets, Saskia J, Laoui, Damya, Spanos, Chad, Parikh, Falguni, Jayaraman, Padmini, Zhang, Bing, Van der Burg, Sjoerd H, Van Ginderachter, Jo A, Melief, Cornelis J M, Sikora, Andrew G

“…Chemoradiotherapy (CRT) remains one of the most common cancer treatment modalities, and recent data suggest that CRT is maximally effective when there is…”
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Neoantigen-specific immunity in low mutation burden colorectal cancers of the consensus molecular subtype 4 by van den Bulk, Jitske, Verdegaal, Els M E, Ruano, Dina, Ijsselsteijn, Marieke E, Visser, Marten, van der Breggen, Ruud, Duhen, Thomas, van der Ploeg, Manon, de Vries, Natasja L, Oosting, Jan, Peeters, Koen C M J, Weinberg, Andrew D, Farina-Sarasqueta, Arantza, van der Burg, Sjoerd H, de Miranda, Noel F C C

“…The efficacy of checkpoint blockade immunotherapies in colorectal cancer is currently restricted to a minority of patients diagnosed with mismatch…”
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Hierarchical modeling for rare event detection and cell subset alignment across flow cytometry samples by Cron, Andrew, Gouttefangeas, Cécile, Frelinger, Jacob, Lin, Lin, Singh, Satwinder K, Britten, Cedrik M, Welters, Marij J P, van der Burg, Sjoerd H, West, Mike, Chan, Cliburn

“…Flow cytometry is the prototypical assay for multi-parameter single cell analysis, and is essential in vaccine and biomarker research for the enumeration of…”
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Superior induction of anti-tumor CTL immunity by extended peptide vaccines involves prolonged, DC-focused antigen presentation by Bijker, Martijn S, van den Eeden, Susan J.F, Franken, Kees L, Melief, Cornelis J.M, van der Burg, Sjoerd H, Offringa, Rienk

“…Anti-tumor vaccines consisting of extended CTL peptides in combination with CpG-ODN were shown to be superior to those comprising minimal CTL epitopes and…”
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Vaccines for established cancer: overcoming the challenges posed by immune evasion by van der Burg, Sjoerd H., Arens, Ramon, Ossendorp, Ferry, van Hall, Thorbald, Melief, Cornelis J. M.

“…Key Points Therapeutic vaccines for the induction of tumour-specific T cell responses show high immunogenicity and clinical efficacy over different formulation…”
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Association of cervical cancer with the presence of CD4⁺ regulatory T cells specific for human papillomavirus antigens by van der Burg, Sjoerd H, Piersma, Sytse J, de Jong, Annemieke, van der Hulst, Jeanette M, Kwappenberg, Kitty M.C, van den Hende, Muriel, Welters, Marij J.P, Van Rood, Jon J, Fleuren, Gert Jan, Melief, Cornelis J.M, Kenter, Gemma G, Offringa, Rienk

“…Because of their important role in the maintenance of self-tolerance, CD4⁺ regulatory T cells prevent autoimmune diseases but also curtail the efficacy of T…”
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The need for improvement of the treatment of advanced and metastatic cervical cancer, the rationale for combined chemo-immunotherapy by van Meir, Helene, Kenter, Gemma G, Burggraaf, Jacobus, Kroep, Judith R, Welters, Marij J P, Melief, Cornelis J M, van der Burg, Sjoerd H, van Poelgeest, Mariette I E

“…The prognosis of patients with metastatic cervical cancer is poor with a median survival of 8-13 months. Despite the potency of chemotherapeutic drugs, this…”
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Demarcated thresholds of tumor-specific CD8 T cells elicited by MCMV-based vaccine vectors provide robust correlates of protection by Beyranvand Nejad, Elham, Ratts, Robert B, Panagioti, Eleni, Meyer, Christine, Oduro, Jennifer D, Cicin-Sain, Luka, Früh, Klaus, van der Burg, Sjoerd H, Arens, Ramon

“…The capacity of cytomegalovirus (CMV) to elicit long-lasting strong T cell responses, and the ability to engineer the genome of this DNA virus positions…”
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Immunotherapeutic Potential of TGF-β Inhibition and Oncolytic Viruses by Groeneveldt, Christianne, van Hall, Thorbald, van der Burg, Sjoerd H., ten Dijke, Peter, van Montfoort, Nadine

“…In cancer immunotherapy, a patient’s own immune system is harnessed against cancer. Immune checkpoint inhibitors release the brakes on tumor-reactive T cells…”
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A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence by Kaplon, Joanna, Zheng, Liang, Meissl, Katrin, Chaneton, Barbara, Selivanov, Vitaly A., Mackay, Gillian, van der Burg, Sjoerd H., Verdegaal, Elizabeth M. E., Cascante, Marta, Shlomi, Tomer, Gottlieb, Eyal, Peeper, Daniel S.

“…Pyruvate dehydrogenase (PDH) is identified as a crucial mediator of BRAF V600E -induced cellular senescence: PDH is activated by BRAF-mediated suppression of…”
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High numbers of activated helper T cells are associated with better clinical outcome in early stage vulvar cancer, irrespective of HPV or p53 status by Kortekaas, Kim E, Santegoets, Saskia J, Abdulrahman, Ziena, van Ham, Vanessa J, van der Tol, Marij, Ehsan, Ilina, van Doorn, Helena C, Bosse, Tjalling, van Poelgeest, Mariëtte I E, van der Burg, Sjoerd H

“…Vulvar squamous cell carcinoma (VSCC) has been suggested to consist of three subtypes; HPV-positive, HPV-negative mutated TP53 or HPV-negative TP53 wildtype,…”
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