Search Results - "van der Burg, S H"

Tbet-positive regulatory T cells accumulate in oropharyngeal cancers with ongoing tumor-specific type 1 T cell responses by Santegoets, S J, Duurland, C L, Jordanova, E S, van Ham, J J, Ehsan, I, van Egmond, S L, Welters, M J P, van der Burg, S H

“…Regulatory T cells (Tregs) may comprise different subsets allowing them to efficiently suppress different types of effector T cells. In this study, we show…”
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Tumor‐infiltrating CD14‐positive myeloid cells and CD8‐positive T‐cells prolong survival in patients with cervical carcinoma by de Vos van Steenwijk, P.J., Ramwadhdoebe, T.H., Goedemans, R., Doorduijn, E.M., van Ham, J.J., Gorter, A., van Hall, T., Kuijjer, M.L., van Poelgeest, M.I.E., van der Burg, S.H., Jordanova, E.S.

“…One of the hallmarks of cancer is the influx of myeloid cells. In our study, we investigated the constitution of tumor‐infiltrating myeloid cells and their…”
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Therapeutic vaccination with papillomavirus E6 and E7 long peptides results in the control of both established virus-induced lesions and latently infected sites in a pre-clinical cottontail rabbit papillomavirus model by Vambutas, A., DeVoti, J., Nouri, M., Drijfhout, J.W., Lipford, G.B., Bonagura, V.R., Burg, S.H. van der, Melief, C.J.M.

“…This study was performed to test the therapeutic efficacy of overlapping long E6 and E7 peptides, containing both CD4+ T-helper and CD8+ CTL epitopes, on…”
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Strong CD8+ lymphocyte infiltration in combination with expression of HLA class I is associated with better tumor control in breast cancer patients treated with neoadjuvant chemotherapy by de Groot, A. F., Blok, E. J., Charehbili, A., Engels, C. C., Smit, V. T. H. B. M., Dekker-Ensink, N. G., Putter, H., Meershoek-Klein Kranenbarg, E., van de Velde, C. J. H., Liefers, G. J., Nortier, J. W. R., Kuppen, P. J. K., van der Burg, S. H., Kroep, J. R.

“…Purpose Tumor-infiltrating lymphocytes (TILs) are associated with pathological complete response (pCR) and survival after neoadjuvant chemotherapy (NAC) in…”
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Dendritic cells in colorectal cancer correlate with other tumor-infiltrating immune cells by DADABAYEV, A. R, SANDEL, M. H, VAN DE VELDE, C. J. H, KUPPEN, P. J. K, MENON, A. G, MORREAU, H, MELIEF, C. J. M, OFFRINGA, R, VAN DER BURG, S. H, JANSSEN-VAN RHIJN, C, ENSINK, N. G, TOLLENAAR, R. A. E. M

“…Dendritic cells (DCs) are the most efficient antigen-presenting cells and play a key role in a cellular antitumor immune response. In this study we…”
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Alterations in classical and nonclassical HLA expression in recurrent and progressive HPV‐induced usual vulvar intraepithelial neoplasia and implications for immunotherapy by van Esch, E.M.G., Tummers, B., Baartmans, V., Osse, E.M., ter Haar, N., Trietsch, M.D., Hellebrekers, B.W.J., Holleboom, C.A.G., Nagel, H.T.C., Tan, L.T., Fleuren, G.J., van Poelgeest, M.I.E., van der Burg, S.H., Jordanova, E.S.

“…Immunotherapy of usual vulvar intraepithelial neoplasia (uVIN) is promising; however, many patients still fail to show clinical responses, which could be…”
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Characterising the local immune responses in cervical intraepithelial neoplasia: a cross‐sectional and longitudinal analysis by Woo, YL, Sterling, J, Damay, I, Coleman, N, Crawford, R, Van Der Burg, SH, Stanley, M

“…Introduction  Immunological competence influences the progression of cervical intraepithelial neoplasia (CIN) to invasive cancer. Information on the local…”
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Autologous dendritic cells pulsed with allogeneic tumour cell lysate induce tumour-reactive T-cell responses in patients with pancreatic cancer: A phase I study by Lau, S.P., Klaase, L., Vink, M., Dumas, J., Bezemer, K., van Krimpen, A., van der Breggen, R., Wismans, L.V., Doukas, M., de Koning, W., Stubbs, A.P., Mustafa, D.A.M., Vroman, H., Stadhouders, R., Nunes, J.B., Stingl, C., de Miranda, N.F.C.C., Luider, T.M., van der Burg, S.H., Aerts, J.G., van Eijck, C.H.J.

“…Pancreatic ductal adenocarcinoma (PDAC) is notorious for its poor prognosis even after curative resection. Responses to immunotherapy are rare and related to…”
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Immunological and Clinical Effects of Vaccines Targeting p53-Overexpressing Malignancies by Vermeij, Renee, Leffers, Ninke, van der Burg, S. H., Melief, C. J., Daemen, Toos, Nijman, Hans Wilhelm

“…Approximately 50% of human malignancies carry p53 mutations, which makes it a potential antigenic target for cancer immunotherapy. Adoptive transfer with…”
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Response definition criteria for ELISPOT assays revisited by Moodie, Z, Price, L, Gouttefangeas, C, Mander, A, Janetzki, S, Löwer, M, Welters, M. J. P, Ottensmeier, C, van der Burg, S. H, Britten, Cedrik M

“…No consensus has been reached on how to determine if an immune response has been detected based on raw data from an ELISPOT assay. The goal of this paper is to…”
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Impact of (chemo)radiotherapy on immune cell composition and function in cervical cancer patients by van Meir, H., Nout, R. A., Welters, M. J. P., Loof, N. M., de Kam, M. L., van Ham, J. J., Samuels, S., Kenter, G. G., Cohen, A. F., Melief, C. J. M., Burggraaf, J., van Poelgeest, M. I. E., van der Burg, S. H.

“…New treatments based on combinations of standard therapeutic modalities and immunotherapy are of potential use, but require a profound understanding of immune…”
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Melanoma cells can be eliminated by sialylated CD43 × CD3 bispecific T cell engager formats in vitro and in vivo by de Jong, G., Bartels, L., Kedde, M., Verdegaal, E. M. E., Gillissen, M. A., Levie, S. E., Cercel, M. G., van Hal-van Veen, S. E., Fatmawati, C., van de Berg, D., Yasuda, E., Claassen, Y. B., Bakker, A. Q., van der Burg, S. H., Schotte, R., Villaudy, J., Spits, H., Hazenberg, M. D., van Helden, P. M., Wagner, K.

“…Targeted cancer therapy with monoclonal antibodies has proven successful for different cancer types but is limited by the availability of suitable antibody…”
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CXCR7 expression is associated with disease-free and disease-specific survival in cervical cancer patients by Schrevel, M, Karim, R, ter Haar, N T, van der Burg, S H, Trimbos, J B M Z, Fleuren, G J, Gorter, A, Jordanova, E S

“…Background: The CXC chemokine receptor (CXCR)7 is involved in tumour development and metastases formation. The aim of the present study was to determine…”
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The presence of human papillomavirus (HPV) in placenta and/or cord blood might result in Th2 polarization by Koskimaa, H.-M., Paaso, A., Welters, M. J. P., Grénman, S., Syrjänen, K., van der Burg, S. H., Syrjänen, S.

“…The purpose of this study was to evaluate if an early exposure to human papillomavirus (HPV) during the prenatal period or infancy could result in…”
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Pre-clinical safety and efficacy of TA-CIN, a recombinant HPV16 L2E6E7 fusion protein vaccine, in homologous and heterologous prime-boost regimens by van der Burg, S.H., Kwappenberg, K.M.C., O'Neill, T., Brandt, R.M.P., Melief, C.J.M., Hickling, J.K., Offringa, R.

“…Human papillomavirus (HPV) E6 and E7 oncoproteins are attractive targets for T-cell-based immunotherapy of cervical intraepithelial neoplasia (CIN) and cancer…”
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T Cell Assays and MIATA: The Essential Minimum for Maximum Impact by Britten, C.M., Janetzki, S., Butterfield, L.H., Ferrari, G., Gouttefangeas, C., Huber, C., Kalos, M., Levitsky, H.I., Maecker, H.T., Melief, C.J.M., O’Donnell-Tormey, J., Odunsi, K., Old, L.J., Ottenhoff, T.H.M., Ottensmeier, C., Pawelec, G., Roederer, M., Roep, B.O., Romero, P., van der Burg, S.H., Walter, S., Hoos, A., Davis, M.M.

“…[...]the current version of MIATA is a testimonial to the freedom and transparency of research and proves the ability of the research community to form…”
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Systemic and local human papillomavirus 16-specific T-cell immunity in patients with head and neck cancer by Heusinkveld, M., Goedemans, R., Briet, R.J.P., Gelderblom, H., Nortier, J.W.R., Gorter, A., Smit, V.T.H.B.M., Langeveld, A.P.M., Jansen, J.C., van der Burg, S.H.

“…Squamous cell carcinomas of the head and neck (HNSCC), in particular those of the oropharynx, can be caused by human papilloma virus Type 16 (HPV16). Whereas…”
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The blood mMDSC to DC ratio is a sensitive and easy to assess independent predictive factor for epithelial ovarian cancer survival by Santegoets, S. J. A. M., de Groot, A. F., Dijkgraaf, E. M., Simões, A. M. Carnaz, van der Noord, V. E., van Ham, J. J., Welters, M. J. P., Kroep, J. R., van der Burg, S. H.

“…Epithelial ovarian cancer (EOC) may cause abnormal blood levels of leukocytes. This paraneoplastic manifestation is associated with a worse response to therapy…”
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The CIMT-monitoring panel: a two-step approach to harmonize the enumeration of antigen-specific CD8+ T lymphocytes by structural and functional assays by Britten, C. M., Gouttefangeas, C., Welters, M. J. P., Pawelec, G., Koch, S., Ottensmeier, C., Mander, A., Walter, S., Paschen, A., Müller-Berghaus, J., Haas, I., Mackensen, A., Køllgaard, T., thor Straten, P., Schmitt, M., Giannopoulos, K., Maier, R., Veelken, H., Bertinetti, C., Konur, A., Huber, C., Stevanović, S., Wölfel, T., van der Burg, S. H.

“…The interpretation of the results obtained from immunomonitoring of clinical trials is a difficult task due to the variety of methods and protocols available…”
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Minimal information about T cell assays: the process of reaching the community of T cell immunologists in cancer and beyond by Britten, C. M., Janetzki, S., van der Burg, S. H., Huber, C., Kalos, M., Levitsky, H. I., Maecker, H. T., Melief, C. J. M., O’Donnell-Tormey, J., Odunsi, K., Old, L. J., Pawelec, G., Roep, B. O., Romero, P., Hoos, A., Davis, M. M.

“…Many assays to evaluate the nature, breadth, and quality of antigen-specific T cell responses are currently applied in human medicine. In most cases,…”
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