Search Results - "van der Bruggen, Pierre"

Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration by Gordon-Alonso, Monica, Hirsch, Thibault, Wildmann, Claude, van der Bruggen, Pierre

“…The presence of T cells in tumors predicts overall survival for cancer patients. However, why most tumors are poorly infiltrated by T cells is barely…”
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Endophilin-A3 and Galectin-8 control the clathrin-independent endocytosis of CD166 by Renard, Henri-François, Tyckaert, François, Lo Giudice, Cristina, Hirsch, Thibault, Valades-Cruz, Cesar Augusto, Lemaigre, Camille, Shafaq-Zadah, Massiullah, Wunder, Christian, Wattiez, Ruddy, Johannes, Ludger, van der Bruggen, Pierre, Alsteens, David, Morsomme, Pierre

“…While several clathrin-independent endocytic processes have been described so far, their biological relevance often remains elusive, especially in…”
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Correlation between Tumor Regression and T Cell Responses in Melanoma Patients Vaccinated with a MAGE Antigen by Lonchay, Christophe, van der Bruggen, Pierre, Connerotte, Thierry, Hanagiri, Takeshi, Coulie, Pierre, Colau, Didier, Lucas, Sophie, Van Pel, Aline, Thielemans, Kris, van Baren, Nicolas, Boon, Thierry

“…The cancer-germline gene MAGE-3 codes for tumor-specific antigens recognized on many tumors by T lymphocytes. A MAGE-3 antigen presented by HLA-A1 has been…”
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Processing and presentation of tumor antigens and vaccination strategies by Bruggen, Pierre van der, Eynde, Benoît J Van den

“…Various new aspects of antigen processing have been uncovered through the study of tumor antigens. One of these is the production of antigenic peptides by…”
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How to measure the immunosuppressive activity of MDSC: assays, problems and potential solutions by Bruger, Annika M., Dorhoi, Anca, Esendagli, Gunes, Barczyk-Kahlert, Katarzyna, van der Bruggen, Pierre, Lipoldova, Marie, Perecko, Tomas, Santibanez, Juan, Saraiva, Margarida, Van Ginderachter, Jo A., Brandau, Sven

“…Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of mononuclear and polymorphonuclear myeloid cells, which are present at very low numbers in…”
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MDSC in Mice and Men: Mechanisms of Immunosuppression in Cancer by Vanhaver, Christophe, van der Bruggen, Pierre, Bruger, Annika M.

“…Myeloid-derived suppressor cells (MDSCs) expand during pathological conditions in both humans and mice and their presence is linked to poor clinical outcomes…”
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Extracellular galectins as controllers of cytokines in hematological cancer by Gordon-Alonso, Monica, Bruger, Annika M., van der Bruggen, Pierre

“…Galectins and cytokines are both secreted proteins whose levels are prognosis factors for several cancers. Extracellular galectins bind to the glycans…”
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Human T cell responses against melanoma by Boon, Thierry, Coulie, Pierre G, Van den Eynde, Benoît J, van der Bruggen, Pierre

“…Many antigens recognized by autologous T lymphocytes have been identified on human melanoma. Melanoma patients usually mount a spontaneous T cell response…”
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A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion by Petit, Anne-Elisabeth, Demotte, Nathalie, Scheid, Benoît, Wildmann, Claude, Bigirimana, René, Gordon-Alonso, Monica, Carrasco, Javier, Valitutti, Salvatore, Godelaine, Danièle, van der Bruggen, Pierre

“…Surface galectin has been shown to contribute to dysfunctions of human tumour-infiltrating lymphocytes (TILs). We show here that galectin-covered CD8 TILs…”
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IRF4 impedes human CD8 T cell function and promotes cell proliferation and PD-1 expression by Hirsch, Thibault, Neyens, Damien, Duhamel, Céline, Bayard, Alexandre, Vanhaver, Christophe, Luyckx, Mathieu, Sala de Oyanguren, Francisco, Wildmann, Claude, Dauguet, Nicolas, Squifflet, Jean-Luc, Montiel, Virginie, Deschamps, Mélanie, van der Bruggen, Pierre

“…Human CD8 tumor-infiltrating lymphocytes (TILs) with impaired effector functions and PD-1 expression are categorized as exhausted. However, the exhaustion-like…”
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Long-Peptide Cross-Presentation by Human Dendritic Cells Occurs in Vacuoles by Peptide Exchange on Nascent MHC Class I Molecules by Ma, Wenbin, Zhang, Yi, Vigneron, Nathalie, Stroobant, Vincent, Thielemans, Kris, van der Bruggen, Pierre, Van den Eynde, Benoît J

“…Cross-presentation enables dendritic cells to present on their MHC class I molecules antigenic peptides derived from exogenous material, through a mechanism…”
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A Galectin-3 Ligand Corrects the Impaired Function of Human CD4 and CD8 Tumor-Infiltrating Lymphocytes and Favors Tumor Rejection in Mice by DEMOTTE, Nathalie, WIEËRS, Grégoire, COURTOY, Pierre J, VAN DER BRUGGEN, Pierre, VAN DER SMISSEN, Patrick, MOSER, Muriel, SCHMIDT, Christopher, THIELEMANS, Kris, SQUIFFLET, Jean-Luc, WEYNAND, Birgit, CARRASCO, Javier, LURQUIN, Christophe

“…Human CD8(+) tumor-infiltrating T lymphocytes (TIL), in contrast with CD8(+) blood cells, show impaired IFN-γ secretion on ex vivo restimulation. We have…”
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IRF1 and NF-kB restore MHC class I-restricted tumor antigen processing and presentation to cytotoxic T cells in aggressive neuroblastoma by Lorenzi, Silvia, Forloni, Matteo, Cifaldi, Loredana, Antonucci, Chiara, Citti, Arianna, Boldrini, Renata, Pezzullo, Marco, Castellano, Aurora, Russo, Vincenzo, van der Bruggen, Pierre, Giacomini, Patrizio, Locatelli, Franco, Fruci, Doriana

“…Neuroblastoma (NB), the most common solid extracranial cancer of childhood, displays a remarkable low expression of Major Histocompatibility Complex class I…”
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Single-Step Antigen Loading and Activation of Dendritic Cells by mRNA Electroporation for the Purpose of Therapeutic Vaccination in Melanoma Patients by BONEHILL, Aude, VAN NUIFEL, An M. T, CORTHALS, Jurgen, TUYAERTS, Sandra, HEIRMAN, Carlo, FRANCOIS, Violaine, COLAU, Didier, VAN DER BRUGGEN, Pierre, NEYNS, Bart, THIELEMANS, Kris

“…Purpose: A critical factor determining the effectiveness of currently used dendritic cell (DC)–based vaccines is the DC activation or maturation status. We…”
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Loss of Effector Function of Human Cytolytic T Lymphocytes Is Accompanied by Major Alterations in N- and O-Glycosylation by Antonopoulos, Aristotelis, Demotte, Nathalie, Stroobant, Vincent, Haslam, Stuart M., van der Bruggen, Pierre, Dell, Anne

“…Most human tumors are not eliminated by the immune system, and therapeutic vaccination shows poor results, a fact that can be explained at least partially by…”
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HELIOS-expressing human CD8 T cells exhibit limited effector functions by Neyens, Damien, Hirsch, Thibault, Abdel Aziz Issa Abdel Hadi, Achraqat, Dauguet, Nicolas, Vanhaver, Christophe, Bayard, Alexandre, Wildmann, Claude, Luyckx, Mathieu, Squifflet, Jean-Luc, D'Hondt, Quentin, Duhamel, Céline, Huaux, Antoine, Montiel, Virginie, Dechamps, Mélanie, van der Bruggen, Pierre

“…The transcription factor HELIOS is primarily known for its expression in CD4 regulatory T cells, both in humans and mice. In mice, HELIOS is found in exhausted…”
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Major histocompatibility complex class I presentation of exogenous soluble tumor antigen fused to the B‐fragment of Shiga toxin by Lee, Ren‐Shiang, Tartour, Eric, Van der Bruggen, Pierre, Vantomme, Valérie, Joyeux, Isabelle, Goud, Bruno, Fridman, Wolf Herman, Johannes, Ludger

“…Targeting exogenous antigen into the MHC class I‐restricted presentation pathway is a prerequisite for the induction of cytotoxic T lymphocytes (CTL) which…”
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An Antigenic Peptide Produced by Peptide Splicing in the Proteasome by Vigneron, Nathalie, Stroobant, Vincent, Chapiro, Jacques, Ooms, Annie, Degiovanni, Gérard, Morel, Sandra, van der Bruggen, Pierre, Boon, Thierry, Van den Eynde, Benoît J.

“…CD8 T lymphocytes recognize peptides of 8 to 10 amino acids presented by class I molecules of the major histocompatibility complex. Here, CD8 T lymphocytes…”
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Messenger RNA-Electroporated Dendritic Cells Presenting MAGE-A3 Simultaneously in HLA Class I and Class II Molecules by Bonehill, Aude, Heirman, Carlo, Tuyaerts, Sandra, Michiels, Annelies, Breckpot, Karine, Brasseur, Francis, Zhang, Yi, van der Bruggen, Pierre, Thielemans, Kris

“…An optimal anticancer vaccine probably requires the cooperation of both CD4(+) Th cells and CD8(+) CTLs. A promising tool in cancer immunotherapy is,…”
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Comparison of stable human Treg and Th clones by transcriptional profiling by Stockis, Julie, Fink, Wolfram, François, Violaine, Connerotte, Thierry, de Smet, Charles, Knoops, Laurent, van der Bruggen, Pierre, Boon, Thierry, Coulie, Pierre G, Lucas, Sophie

“…From cancerous and non-cancerous patients, we derived stable clones of CD4⁺ Treg, defined as clones that expressed high CD25 at rest, were anergic in vitro,…”
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