Search Results - "van der Boom, Hans"

Apolipoprotein C-III deficiency accelerates triglyceride hydrolysis by lipoprotein lipase in wild-type and apoE knockout mice by Jong, M C, Rensen, P C, Dahlmans, V E, van der Boom, H, van Berkel, T J, Havekes, L M

“…Previous studies with hypertriglyceridemic APOC3 transgenic mice have suggested that apolipoprotein C-III (apoC-III) may inhibit either the apoE-mediated…”
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Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus by Mulder, Monique, Jansen, Paula J, Janssen, Ben J.A, van de Berg, Wilma D.J, van der Boom, Hans, Havekes, Louis M, de Kloet, Ron E, Ramaekers, Frans C.S, Blokland, Arjan

“…The low-density lipoprotein receptor (LDLR) is the first described receptor for apolipoprotein E (apoE). We hypothesize that the absence of the LDLR, similar…”
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Acyl-CoA: cholesterol acyltransferase inhibitor avasimibe reduces atherosclerosis in addition to its cholesterol-lowering effect in ApoE3-Leiden mice by DELSING, Dianne J. M, OFFERMAN, Erik H, VAN DUYVENVOORDE, Wim, VAN DER BOOM, Hans, DE WIT, Elly C. M, GIJBELS, Marion J. J, VAN DER LAARSE, Arnoud, J. WOUTER, JOUKEMA, HAVEKES, Louis M, PRINCEN, Hans M. G

“…The present study investigated whether the ACAT inhibitor avasimibe can reduce atherogenesis independently of its cholesterol-lowering effect in ApoE*3-Leiden…”
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Stimulation of the in Vivo Production of Very Low Density Lipoproteins by Apolipoprotein E Is Independent of the Presence of the Low Density Lipoprotein Receptor by Teusink, Bas, Mensenkamp, Arjen R., van der Boom, Hans, Kuipers, Folkert, van Dijk, Ko Willems, Havekes, Louis M.

“…Apolipoprotein (apo) E stimulates the secretion of very low density lipoproteins (VLDLs) by an as yet unknown mechanism. Recently, a working mechanism for apoE…”
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In the Absence of Endogenous Mouse Apolipoprotein E, Apolipoprotein E2(Arg-158 → Cys) Transgenic Mice Develop More Severe Hyperlipoproteinemia than Apolipoprotein E3-Leiden Transgenic Mice by van Vlijmen, Bart J.M., van Dijk, Ko Willems, van't Hof, H. Belinda, van Gorp, Patrick J.J., van der Zee, André, van der Boom, Hans, Breuer, Marco L., Hofker, Marten H., Havekes, Louis M.

“…Apolipoprotein E*2(Arg-158 → Cys) (APOE*2) transgenic mice were generated and compared to the previously generated apolipoprotein E*3-Leiden (APOE*3-Leiden)…”
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Reversal of Hypercholesterolemia in Apolipoprotein E2 and Apolipoprotein E3-Leiden Transgenic Mice by Adenovirus-Mediated Gene Transfer of the VLDL Receptor by van Dijk, Ko Willems, van Vlijmen, Bart J.M, van der Zee, Andre, van't Hof, Belinda, van der Boom, Hans, Kobayashi, Kunihisa, Chan, Lawrence, Havekes, Louis M, Hofker, Marten H

“…We have investigated the interaction of apolipoprotein E2 (Arg158 -Cys) (apoE2) and apolipoprotein E3Leiden (apoE3-Leiden) with the very low density…”
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Apolipoprotein E Is Resistant to Intracellular Degradation in Vitro and in Vivo by Rensen, Patrick C.N., Jong, Miek C., van Vark, Leonie C., van der Boom, Hans, Hendriks, Wendy L., van Berkel, Theo J.C., Biessen, Erik A.L., Havekes, Louis M.

“…Apolipoprotein E (apoE) is an important determinant for the uptake of triglyceride-rich lipoproteins and emulsions by the liver, but the intracellular pathway…”
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Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice by VAN VLIJMEN, B. J. M, VAN DEN MAAGDENBERG, A. M. J. M, GIJBELS, M. J. J, VAN DER BOOM, H, HOGENESCH, H, FRANTS, R. R, HOFKER, M. H, HAVEKES, L. M

“…Apolipoprotein E3-Leiden (APOE*3-Leiden) transgenic mice have been used to study the effect of different cholesterol-containing diets on the remnant…”
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Apolipoprotein E is resistant to intracellular degradation in vitro and in vivo: evidence for retroendocytosis by Rensen, P.C.N, Jong, M.C, Vark, L.C. van, Boom, H. van der, Hendriks, W.L, BErkel, T.J.C. van, Biessen, E.A.L, Havekes, L.M

“…Apolipoprotein E (apoE) is an important determinant for the uptake of triglyceride-rich lipoproteins and emulsions by the liver, but the intracellular pathway…”
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Dietary Plant Stanol Esters Reduce VLDL Cholesterol Secretion and Bile Saturation in Apolipoprotein E3-Leiden Transgenic Mice by Volger, Oscar L, van der Boom, Hans, de Wit, Elly C.M, van Duyvenvoorde, Wim, Hornstra, Gerard, Plat, Jogchum, Havekes, Louis M, Mensink, Ronald P, Princen, Hans M.G

“…ABSTRACT—Dietary plant stanols lower serum cholesterol levels in humans and in hyperlipidemic rodents, mainly by inhibition of the intestinal cholesterol…”
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Rosuvastatin Reduces Plasma Lipids by Inhibiting VLDL Production and Enhancing Hepatobiliary Lipid Excretion in ApoE3-Leiden Mice by Delsing, Dianne J. M, Post, Sabine M, Groenendijk, Martine, Solaas, Karianne, van der Boom, Hans, van Duyvenvoorde, Wim, de Wit, Elly C. M, Bloks, Vincent W, Kuipers, Folkert, Havekes, Louis M, Princen, Hans M. G

“…The present study was designed to investigate the lipid-lowering properties and mechanisms of action of a new HMG-CoA reductase inhibitor, rosuvastatin, in…”
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Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia by van den Maagdenberg, A.M., Hofker, M.H., Krimpenfort, P.J., de Bruijn, I., van Vlijmen, B., van der Boom, H., Havekes, L.M., Frants, R.R.

“…Apolipoprotein (apo) E3-Leiden, described in a large Dutch family, is associated with a dominantly inherited form of familial dysbetalipoproteinemia. To study…”
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Reversal of hyperlipidaemia in apolipoprotein C1 transgenic mice by adenovirus-mediated gene delivery of the low-density-lipoprotein receptor, but not by the very-low-density-lipoprotein receptor by Jong, M C, van Dijk, K W, Dahlmans, V E, Van der Boom, H, Kobayashi, K, Oka, K, Siest, G, Chan, L, Hofker, M H, Havekes, L M

“…We have shown previously that human apolipoprotein (apo)C1 transgenic mice exhibit hyperlipidaemia, due primarily to an impaired clearance of very-low-density…”
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Modulation of very low density lipoprotein production and clearance contributes to age- and gender- dependent hyperlipoproteinemia in apolipoprotein E3-Leiden transgenic mice by van Vlijmen, B J, van 't Hof, H B, Mol, M J, van der Boom, H, van der Zee, A, Frants, R R, Hofker, M H, Havekes, L M

“…Apolipoprotein E3-Leiden (APOE*3-Leiden) transgenic mice have been studied to identify factors modulating chylomicron and VLDL remnant lipoprotein metabolism…”
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Lipoprotein lipase stimulates the binding and uptake of moderately oxidized low-density lipoprotein by J774 macrophages by Hendriks, W L, van der Boom, H, van Vark, L C, Havekes, L M

“…Lipoprotein lipase (LPL) stimulates the uptake of low-density lipoprotein (LDL) and very-low-density lipoprotein (VLDL) in different cell types, including…”
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Reversal of hyperlipidaemia in apolipoprotein C1 transgenic mice by adenovirus-mediated gene delivery of the low-density-lipoprotein receptor, but not by the very-low-density-lipoprotein receptor by JONG, Miek C., DIJK, Ko WILLEMS Van, DAHLMANS, Vivian E.H., BOOM, Hans Van Der, KOBAYASHI, Kunisha, OKA, Kazuhito, SIEST, Gerard, CHAN, Lawrence, HOFKER, Marten H., HAVEKES, Louis M.

“…We have shown previously that human apolipoprotein (apo)C1 transgenic mice exhibit hyperlipidaemia, due primarily to an impaired clearance of very-low-density…”
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Hyperlipidemia of ApoE2(Arg158-Cys) and ApoE3-Leiden Transgenic Mice Is Modulated Predominantly by LDL Receptor Expression by van Dijk, Ko Willems, van Vlijmen, Bart J. M, de Winther, Menno P. J, Hof, Belinda van ’t, van der Zee, Andre, van der Boom, Hans, Havekes, Louis M, Hofker, Marten H

“…To investigate the relative roles of the LDL receptor– and non–LDL receptor–mediated pathways in the clearance of apolipoprotein E (apoE) variants in vivo, we…”
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Inefficient degradation of triglyceride-rich lipoprotein by HepG2 cells is due to a retarded transport to the lysosomal compartment by Lombardi, P, Mulder, M, van der Boom, H, Frants, R R, Havekes, L M

“…Binding studies at 37 degrees C showed that lipoprotein lipase-treated very low density lipoproteins (LPL-VLDL) and very low density lipoproteins (VLDL), once…”
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Triglyceride-rich lipoproteins of subjects heterozygous for apolipoprotein E2(Lys146-->Gln) are inefficiently converted to cholesterol-rich lipoproteins by Mulder, M, van der Boom, H, de Knijff, P, Braam, C, van den Maagdenberg, A, Leuven, J A, Havekes, L M

“…The APOE*2(Lys146-->Gln) allele behaves like a dominant trait in the expression of familial dysbetalipoproteinemia (FD) (Smit et al., J. Lipid Res. 1990; 31:…”
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Molecular aspects of age-related changes in albumin synthesis in female WAG/Rij rats by Horbach, G J, van der Boom, H, van Bezooijen, C F, Yap, S H

“…The rate of albumin gene transcription and the level of albumin RNA sequences in liver nuclei of rats of various ages were determined to investigate the…”
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