COVID-19 Incidence and Disease Course Among Patients at an Allergy Department

Background Since the coronavirus pandemic in 2020, there is not much reported about the disease course of COVID-19 in patients with allergic diseases. Objectives The aim of this study was to investigate the cumulative incidence and severity of COVID-19 among patients from the allergy department comp...

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Published in:	Allergy & rhinology (Providence, R.I.) Vol. 14; p. 27534030231172391
Main Authors:	van der Aa, Louise E., van Egmond, Inge S., van der Sluijs, Martijn, den Otter, A.A. Sophie, Bosmans, Nadie H.M., van Beek, Sabine E., Hartman, Angela, Guchelaar, Niels A.D., van Daele, Paul L.A., van Maaren, Maurits S., van Hagen, P. Martin, Hermans, Maud A.W., Rombach, Saskia M.
Format:	Journal Article
Language:	English
Published:	Los Angeles, CA SAGE Publications 01-01-2023 Sage Publications Ltd
Subjects:	Allergic diseases Allergies Coronaviruses COVID-19 Disease Households Original Pandemics Severe acute respiratory syndrome coronavirus 2 COVID-19 allergy SARS-CoV-2 hypersensitivity incidence
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Summary:	Background Since the coronavirus pandemic in 2020, there is not much reported about the disease course of COVID-19 in patients with allergic diseases. Objectives The aim of this study was to investigate the cumulative incidence and severity of COVID-19 among patients from the allergy department compared with the general Dutch population and people from their household. Design We conducted a comparative longitudinal cohort study. Methods In this study patients of the allergy department were included with their household members as a control group. Data from the beginning of the pandemic were systematically obtained through questionnaires by telephonic interviews and retrieved from electronic patient files between October 15, 2020 and January 29, 2021. Main outcomes were confirmed SARS-CoV-2 infection, disease duration, hospitalization, intensive care admission, and mortality. Questions regarding applied social distancing measures were inventoried as well. Results Three hundred and eighty nine patients (median age 39.1 (18.7-84.7) years, 69.9% female) and 441 household members (median age 42.0 (18.0-91.5), 44.1% female) were included. The cumulative COVID-19 incidence in patients was higher compared with the general population (10.5% vs 5.6%, P < .001). In total, 41 (10.5%) patients attending the allergy clinic compared to 38 (8.6%) household members were infected with SARS-CoV-2 (P = .407). Median disease duration was 11.0 (0.0-61.0) days in patients compared to 10.5(1.0-232.0) days in household members (P = .996). Conclusion The cumulative COVID-19 incidence in patients from the allergy cohort was higher compared with the general Dutch population, but similar compared with household members. There was no difference in symptoms, disease duration, or hospitalization rate between the allergy cohort and their household members.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 both authors contributed equally
ISSN:	2753-4030 2152-6575 2753-4030 2152-6567
DOI:	10.1177/27534030231172391