Search Results - "van den Wollenberg, D J"

A strategy for genetic modification of the spike-encoding segment of human reovirus T3D for reovirus targeting by van den Wollenberg, D J M, van den Hengel, S K, Dautzenberg, I J C, Cramer, S J, Kranenburg, O, Hoeben, R C

“…Human Orthoreovirus Type 3 Dearing is not pathogenic to humans and has been evaluated clinically as an oncolytic agent. Its transduction efficiency and the…”
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Replicating reoviruses with a transgene replacing the codons for the head domain of the viral spike by van den Wollenberg, D J M, Dautzenberg, I J C, Ros, W, Lipińska, A D, van den Hengel, S K, Hoeben, R C

“…The capacity to modify the reovirus genome facilitates generation of new therapeutic reoviruses. We describe a method for generating replication-competent…”
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Creation of immune 'stealth' genes for gene therapy through fusion with the Gly-Ala repeat of EBNA-1 by OSSEVOORT, M, VISSER, B. M. J, VAN DEN WOLLENBERG, D. J. M, VAN DER VOORT, E. I. H, OFFRINGA, R, MELIEF, C. J. M, TOES, R. E. M, HOEBEN, R. C

“…A major obstacle in gene-therapy protocols is T-cell-mediated destruction of transgene-expressing cells. Therefore new approaches are needed to prevent rapid…”
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Immunosuppression promotes reovirus therapy of colorectal liver metastases by Smakman, N, van der Bilt, J D W, van den Wollenberg, D J M, Hoeben, R C, Borel Rinkes, I H M, Kranenburg, O

“…Mortality due to colorectal cancer (CRC) is high and is associated with the development of liver metastases. Approximately 40% of human CRCs harbor an…”
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Transient infection of freshly isolated human colorectal tumor cells by reovirus T3D intermediate subviral particles by van Houdt, W J, Smakman, N, van den Wollenberg, D J M, Emmink, B L, Veenendaal, L M, van Diest, P J, Hoeben, R C, Borel Rinkes, I H M, Kranenburg, O

“…Reovirus T3D preferentially kills tumor cells expressing Ras oncogenes and has shown great promise as an anticancer agent in various preclinical tumor models…”
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Mammalian orthoreovirus T3D infects U-118 MG cell spheroids independent of junction adhesion molecule-A by Dautzenberg, I J C, van den Wollenberg, D J M, van den Hengel, S K, Limpens, R W A, Bárcena, M, Koster, A J, Hoeben, R C

“…In the canonical pathway, infection of cells by the wild-type mammalian orthoreovirus Type 3 Dearing (T3D) is dependent on the interaction of the viral spike…”
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Heterogeneous reovirus susceptibility in human glioblastoma stem-like cell cultures by van den Hengel, S K, Balvers, R K, Dautzenberg, I J C, van den Wollenberg, D J M, Kloezeman, J J, Lamfers, M L, Sillivis-Smit, P A E, Hoeben, R C

“…Glioblastoma (GB) is a devastating disease for which new treatment modalities are needed. Efficacious therapy requires the removal of stem-cell like cells,…”
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Specific tumor-cell killing with adenovirus vectors containing the apoptin gene by Pietersen, A M, van der Eb, M M, Rademaker, H J, van den Wollenberg, D J, Rabelink, M J, Kuppen, P J, van Dierendonck, J H, van Ormondt, H, Masman, D, van de Velde, C J, van der Eb, A J, Hoeben, R C, Noteborn, M H

“…Specificity is an essential prerequisite for cancer gene therapy. Recently we described that apoptin, a protein of 121 amino acids which is derived from the…”
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Expression of the blood-clotting factor-VIII cDNA is repressed by a transcriptional silencer located in its coding region by HOEBEN, R. C, FALLAUX, F. J, CRAMER, S. J, VAN DEN WOLLENBERG, D. J. M, VAN ORMONDT, H, BRIËT, E, VAN DER EB, A. J

“…Hemophilia A is caused by a deficiency of factor-VIII procoagulant (fVIII) activity. The current treatment by frequent infusions of plasma-derived fVIII…”
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The human clotting factor VIII cDNA contains an autonomously replicating sequence consensus- and matrix attachment region-like sequence that binds a nuclear factor, represses heterologous gene expression, and mediates the transcriptional effects of sodium butyrate by Fallaux, Frits J., Hoeben, Rob C., Cramer, Steve J., Wollenberg, Diana J. M. van den, Briët, Ernest, Ormondt, Hans van, Eb, Alex J. van der

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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New helper cells and matched early region 1-deleted adenovirus vectors prevent generation of replication-competent adenoviruses by Fallaux, F J, Bout, A, van der Velde, I, van den Wollenberg, D J, Hehir, K M, Keegan, J, Auger, C, Cramer, S J, van Ormondt, H, van der Eb, A J, Valerio, D, Hoeben, R C

“…The presence of replication-competent adenoviruses (RCAs) in batches of replication-defective adenovirus (Ad) vectors is a major problem for the application of…”
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Baculovirus-assisted Reovirus Infection in Monolayer and Spheroid Cultures of Glioma cells by Dautzenberg, Iris J. C., van den Hengel, Sanne K., de Vrij, Jeroen, Ravesloot, Lars, Cramer, Steve J., Hong, Saw-See, van den Wollenberg, Diana J. M., Boulanger, Pierre, Hoeben, Rob C.

“…The mammalian orthoreovirus Type 3 Dearing has great potential as oncolytic agent in cancer therapy. One of the bottlenecks that hampers its antitumour…”
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Insertion of the human cytomegalovirus enhancer into a myeloproliferative sarcoma virus long terminal repeat creates a high-expression retroviral vector by van den Wollenberg, D J, Hoeben, R C, van Ormondt, H, van der Eb, A J

“…A new retroviral vector is characterized in which the enhancer in the long terminal repeat of myeloproliferative sarcoma virus (MPSV) is combined with the…”
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