Search Results - "van den Hoogenhof, Maarten M"

Physiological and unappreciated roles of CaMKII in the heart by Beckendorf, Jan, van den Hoogenhof, Maarten M. G., Backs, Johannes

“…In the cardiomyocyte, CaMKII has been identified as a nodal influencer of excitation–contraction and also excitation–transcription coupling. Its activity can…”
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Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy by Grosch, Markus, Schraft, Laura, Chan, Adrian, Küchenhoff, Leonie, Rapti, Kleopatra, Ferreira, Anne-Maud, Kornienko, Julia, Li, Shengdi, Radke, Michael H., Krämer, Chiara, Clauder-Münster, Sandra, Perlas, Emerald, Backs, Johannes, Gotthardt, Michael, Dieterich, Christoph, van den Hoogenhof, Maarten M. G., Grimm, Dirk, Steinmetz, Lars M.

“…Dilated cardiomyopathy is the second most common cause for heart failure with no cure except a high-risk heart transplantation. Approximately 30% of patients…”
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The Transcription Factor GATA-6 Regulates Pathological Cardiac Hypertrophy by van Berlo, Jop H, Elrod, John W, van den Hoogenhof, Maarten M.G, York, Allen J, Aronow, Bruce J, Duncan, Stephen A, Molkentin, Jeffery D

“…RATIONALE:The transcriptional code that programs maladaptive cardiac hypertrophy involves the zinc finger–containing DNA binding factor GATA-4. The highly…”
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A mutation in the glutamate-rich region of RNA-binding motif protein 20 causes dilated cardiomyopathy through missplicing of titin and impaired Frank-Starling mechanism by Beqqali, Abdelaziz, Bollen, Ilse A E, Rasmussen, Torsten B, van den Hoogenhof, Maarten M, van Deutekom, Hanneke W M, Schafer, Sebastian, Haas, Jan, Meder, Benjamin, Sørensen, Keld E, van Oort, Ralph J, Mogensen, Jens, Hubner, Norbert, Creemers, Esther E, van der Velden, Jolanda, Pinto, Yigal M

“…Mutations in the RS-domain of RNA-binding motif protein 20 (RBM20) have recently been identified to segregate with aggressive forms of familial dilated…”
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Cardiac circRNAs arise mainly from constitutive exons rather than alternatively spliced exons by Aufiero, Simona, van den Hoogenhof, Maarten M G, Reckman, Yolan J, Beqqali, Abdelaziz, van der Made, Ingeborg, Kluin, Jolanda, Khan, Mohsin A F, Pinto, Yigal M, Creemers, Esther E

“…Circular RNAs (circRNAs) are a relatively new class of RNA molecules, and knowledge about their biogenesis and function is still in its infancy. It was…”
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Editorial: RNA Biology in Cardiovascular Disease by van den Hoogenhof, Maarten M. G., El Azzouzi, Hamid, Beqqali, Abdelaziz

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CaMKIIδ Splice Variants in the Healthy and Diseased Heart by Duran, Javier, Nickel, Lennart, Estrada, Manuel, Backs, Johannes, van den Hoogenhof, Maarten M G

“…RNA splicing has been recognized in recent years as a pivotal player in heart development and disease. The Ca /calmodulin dependent protein kinase II delta…”
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AAV9-mediated Rbm24 overexpression induces fibrosis in the mouse heart by van den Hoogenhof, Maarten M. G., van der Made, Ingeborg, de Groot, Nina E., Damanafshan, Amin, van Amersfoorth, Shirley C. M., Zentilin, Lorena, Giacca, Mauro, Pinto, Yigal M., Creemers, Esther E.

“…The RNA-binding protein Rbm24 has recently been identified as a pivotal splicing factor in the developing heart. Loss of Rbm24 in mice disrupts cardiac…”
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RBM20 Regulates Circular RNA Production From the Titin Gene by Khan, Mohsin A.F, Reckman, Yolan J, Aufiero, Simona, van den Hoogenhof, Maarten M.G, van der Made, Ingeborg, Beqqali, Abdelaziz, Koolbergen, Dave R, Rasmussen, Torsten B, van der Velden, Jolanda, Creemers, Esther E, Pinto, Yigal M

“…RATIONALE:RNA-binding motif protein 20 (RBM20) is essential for normal splicing of many cardiac genes, and loss of RBM20 causes dilated cardiomyopathy. Given…”
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RNA Splicing: Regulation and Dysregulation in the Heart by van den Hoogenhof, Maarten M.G, Pinto, Yigal M, Creemers, Esther E

“…RNA splicing represents a post-transcriptional mechanism to generate multiple functional RNAs or proteins from a single transcript. The evolution of RNA…”
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The microRNA-15 family inhibits the TGFβ-pathway in the heart by Tijsen, Anke J, van der Made, Ingeborg, van den Hoogenhof, Maarten M, Wijnen, Wino J, van Deel, Elza D, de Groot, Nina E, Alekseev, Sergey, Fluiter, Kees, Schroen, Blanche, Goumans, Marie-José, van der Velden, Jolanda, Duncker, Dirk J, Pinto, Yigal M, Creemers, Esther E

“…The overloaded heart remodels by cardiomyocyte hypertrophy and interstitial fibrosis, which contributes to the development of heart failure. Signalling via the…”
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The RNA-binding protein Rbm38 is dispensable during pressure overload-induced cardiac remodeling in mice by van den Hoogenhof, Maarten M G, van der Made, Ingeborg, Beqqali, Abdelaziz, de Groot, Nina E, Damanafshan, Amin, van Oort, Ralph J, Pinto, Yigal M, Creemers, Esther E

“…The importance of tightly controlled alternative pre-mRNA splicing in the heart is emerging. The RNA binding protein Rbm24 has recently been identified as a…”
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Insights into alternative splicing of sarcomeric genes in the heart by Weeland, Cornelis J, van den Hoogenhof, Maarten M, Beqqali, Abdelaziz, Creemers, Esther E

“…Abstract Driven by rapidly evolving technologies in next-generation sequencing, alternative splicing has emerged as a crucial layer in gene expression, greatly…”
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The Hypoxia-Inducible MicroRNA Cluster miR-199a∼214 Targets Myocardial PPARδ and Impairs Mitochondrial Fatty Acid Oxidation by el Azzouzi, Hamid, Leptidis, Stefanos, Dirkx, Ellen, Hoeks, Joris, van Bree, Bianca, Brand, Karl, McClellan, Elizabeth A., Poels, Ella, Sluimer, Judith C., van den Hoogenhof, Maarten M.G., Armand, Anne-Sophie, Yin, Xiaoke, Langley, Sarah, Bourajjaj, Meriem, Olieslagers, Serve, Krishnan, Jaya, Vooijs, Marc, Kurihara, Hiroki, Stubbs, Andrew, Pinto, Yigal M., Krek, Wilhelm, Mayr, Manuel, Martins, Paula A. da Costa, Schrauwen, Patrick, De Windt, Leon J.

“…Peroxisome proliferator-activated receptor δ (PPARδ) is a critical regulator of energy metabolism in the heart. Here, we propose a mechanism that integrates…”
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Deep phenotyping of two preclinical mouse models and a cohort of RBM20 mutation carriers reveals no sex-dependent disease severity in RBM20 cardiomyopathy by Lennermann, David C, Pepin, Mark E, Grosch, Markus, Konrad, Laura, Kemmling, Elena, Hartmann, Joshua, Nolte, Janica L, Clauder-Münster, Sandra, Kayvanpour, Elham, Sedaghat-Hamedani, Farbod, Haas, Jan, Meder, Benjamin, van den Boogaard, Malou, Amin, Ahmad S, Dewenter, Matthias, Krüger, Marcus, Steinmetz, Lars M, Backs, Johannes, van den Hoogenhof, Maarten M G

“…cardiomyopathy is an arrhythmogenic form of dilated cardiomyopathy caused by mutations in the splicing factor RBM20. A recent study found a more severe…”
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The MEF2 transcriptional target DMPK induces loss of sarcomere structure and cardiomyopathy by Damanafshan, Amin, Elzenaar, Ies, Samson-Couterie, Benoit, van der Made, Ingeborg, Bourajjaj, Meriem, van den Hoogenhof, Maarten M, van Veen, Henk A, Picavet, Daisy I, Beqqali, Abdelaziz, Ehler, Elisabeth, De Windt, Leon J, Pinto, Yigal M, van Oort, Ralph J

“…Abstract Aims The pathology of heart failure is characterized by poorly contracting and dilated ventricles. At the cellular level, this is associated with…”
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Orphan nuclear receptor Nur77 affects cardiomyocyte calcium homeostasis and adverse cardiac remodelling by Medzikovic, Lejla, Schumacher, Cees A., Verkerk, Arie O., van Deel, Elza D., Wolswinkel, Rianne, van der Made, Ingeborg, Bleeker, Natascha, Cakici, Daniella, van den Hoogenhof, Maarten M. G., Meggouh, Farid, Creemers, Esther E., Remme, Carol Ann, Baartscheer, Antonius, de Winter, Robbert J., de Vries, Carlie J. M., Arkenbout, E. Karin, de Waard, Vivian

“…Distinct stressors may induce heart failure. As compensation, β-adrenergic stimulation enhances myocardial contractility by elevating cardiomyocyte…”
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RBM20 Mutations Induce an Arrhythmogenic Dilated Cardiomyopathy Related to Disturbed Calcium Handling by van den Hoogenhof, Maarten M.G, Beqqali, Abdelaziz, Amin, Ahmad S, van der Made, Ingeborg, Aufiero, Simona, Khan, Mohsin A.F, Schumacher, Cees A, Jansweijer, Joeri A, van Spaendonck-Zwarts, Karin Y, Remme, Carol Ann, Backs, Johannes, Verkerk, Arie O, Baartscheer, Antonius, Pinto, Yigal M, Creemers, Esther E

“…BACKGROUND:Mutations in RBM20 (RNA-binding motif protein 20) cause a clinically aggressive form of dilated cardiomyopathy, with an increased risk of malignant…”
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Post-natal myogenic and adipogenic developmental: Defects and metabolic impairment upon loss of A-type lamins by Kubben, Nard, Voncken, Jan Willem, Konings, Gonda, van Weeghel, Michel, van den Hoogenhof, Maarten M.G., Gijbels, Marion, van Erk, Arie, Schoonderwoerd, Kees, van den Bosch, Bianca, Dahlmans, Vivian, Calis, Chantal, Houten, Sander M., Misteli, Tom, Pinto, Yigal M.

“…A-type lamins are a major component of the nuclear lamina. Mutations in the LMNA gene, which encodes the A-type lamins A and C, cause a set of phenotypically…”
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