Search Results - "van den Heuvel, Lambertus W P J"

Levamisole Modulation of Podocytes’ Actin Cytoskeleton in Nephrotic Syndrome by Veissi, Susan T, van den Berge, Tijmen, van Wijk, Joanna A. E, van der Velden, Thea, Classens, René, Lunsonga, Lynn, Brockotter, Rick, Kaffa, Charlotte, Bervoets, Sander, Smeets, Bart, van den Heuvel, Lambertus P. W. J, Schreuder, Michiel F

“…Podocytes play a central role in glomerular diseases such as (idiopathic) nephrotic syndrome (iNS). Glucocorticoids are the gold standard therapy for iNS…”
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The role of properdin in complement-mediated renal diseases: a new player in complement-inhibiting therapy? by Michels, Marloes A. H. M., Volokhina, Elena B., van de Kar, Nicole C. A. J., van den Heuvel, Lambertus P. W. J.

“…Properdin is known as the only positive regulator of the complement system. Properdin promotes the activity of this defense system by stabilizing its key…”
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Mitochondrial network complexity and pathological decrease in complex I activity are tightly correlated in isolated human complex I deficiency by Koopman, Werner J H, Visch, Henk-Jan, Verkaart, Sjoerd, van den Heuvel, Lambertus W P J, Smeitink, Jan A M, Willems, Peter H G M

“…Complex I (NADH:ubiquinone oxidoreductase) is the largest multisubunit assembly of the oxidative phosphorylation system, and its malfunction is associated with…”
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Shiga Toxin Selectively Upregulates Expression of Syndecan-4 and Adhesion Molecule ICAM-1 in Human Glomerular Microvascular Endothelium by Volokhina, Elena B, Feitz, Wouter J C, Elders, Lonneke M, van der Velden, Thea J A M, van de Kar, Nicole C A J, van den Heuvel, Lambertus P W J

“…Hemolytic uremic syndrome (HUS) is a severe renal disease that is often preceded by infection with Shiga toxin (Stx)-producing (STEC). The exact mechanism of…”
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Transferrin mutations at the glycosylation site complicate diagnosis of congenital disorders of glycosylation type I by Guillard, Mailys, Wada, Yoshinao, Hansikova, Hana, Yuasa, Isao, Vesela, Katerina, Ondruskova, Nina, Kadoya, Machiko, Janssen, Alice, Van den Heuvel, Lambertus P. W. J., Morava, Eva, Zeman, Jiri, Wevers, Ron A., Lefeber, Dirk J.

“…Congenital disorders of glycosylation (CDG) form a group of metabolic disorders caused by deficient glycosylation of proteins and/or lipids. Isoelectric…”
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Long-term follow-up including extensive complement analysis of a pediatric C3 glomerulopathy cohort by Michels, Marloes A. H. M., Wijnsma, Kioa L., Kurvers, Roel A. J., Westra, Dineke, Schreuder, Michiel F., van Wijk, Joanna A. E., Bouts, Antonia H. M., Gracchi, Valentina, Engels, Flore A. P. T., Keijzer-Veen, Mandy G., Dorresteijn, Eiske M., Volokhina, Elena B., van den Heuvel, Lambertus P. W. J., van de Kar, Nicole C. A. J.

“…Background C3 glomerulopathy (C3G) is a rare kidney disorder characterized by predominant glomerular depositions of complement C3. C3G can be subdivided into…”
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Case Report: Variable Pharmacokinetic Profile of Eculizumab in an aHUS Patient by Bouwmeester, Romy N, Ter Avest, Mendy, Wijnsma, Kioa L, Duineveld, Caroline, Ter Heine, Rob, Volokhina, Elena B, Van Den Heuvel, Lambertus P W J, Wetzels, Jack F M, van de Kar, Nicole C A J

“…With the introduction of eculizumab, a C5-inhibitor, morbidity and mortality improved significantly for patients with atypical hemolytic uremic syndrome…”
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Whole Exome Sequencing in Patients with the Cuticular Drusen Subtype of Age-Related Macular Degeneration by Duvvari, Maheswara R, van de Ven, Johannes P H, Geerlings, Maartje J, Saksens, Nicole T M, Bakker, Bjorn, Henkes, Arjen, Neveling, Kornelia, del Rosario, Marisol, Westra, Dineke, van den Heuvel, Lambertus P W J, Schick, Tina, Fauser, Sascha, Boon, Camiel J F, Hoyng, Carel B, de Jong, Eiko K, den Hollander, Anneke I

“…Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in elderly people worldwide. Cuticular drusen (CD) is a clinical subtype…”
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Different Aspects of Classical Pathway Overactivation in Patients With C3 Glomerulopathy and Immune Complex-Mediated Membranoproliferative Glomerulonephritis by Michels, Marloes A H M, van de Kar, Nicole C A J, van Kraaij, Sanne A W, Sarlea, Sebastian A, Gracchi, Valentina, Engels, Flore A P T, Dorresteijn, Eiske M, van der Deure, Johannes, Duineveld, Caroline, Wetzels, Jack F M, van den Heuvel, Lambertus P W J, Volokhina, Elena B

“…The rare and heterogeneous kidney disorder C3 glomerulopathy (C3G) is characterized by dysregulation of the alternative pathway (AP) of the complement system…”
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Glyco-iELISA: a highly sensitive and unambiguous serological method to diagnose STEC-HUS caused by serotype O157 by Wijnsma, Kioa L., Veissi, Susan T., van Bommel, Sheila A. M., Heuver, Rik, Volokhina, Elena B., Comerci, Diego J., Ugalde, Juan E., van de Kar, Nicole C. A. J., van den Heuvel, Lambertus P. W. J.

“…Background Providing proof of presence of Shiga toxin–producing E. coli (STEC) infection forms the basis for differentiating STEC-hemolytic uremic syndrome…”
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Ca2+-mobilizing agonists increase mitochondrial ATP production to accelerate cytosolic Ca2+ removal: aberrations in human complex I deficiency by Visch, Henk-Jan, Koopman, Werner J H, Zeegers, Dimphy, van Emst-de Vries, Sjenet E, van Kuppeveld, Frank J M, van den Heuvel, Lambertus W P J, Smeitink, Jan A M, Willems, Peter H G M

“…Previously, we reported that both the bradykinin (Bk)-induced increase in mitochondrial ATP concentration ([ATP]M) and the rate of cytosolic Ca2+ removal are…”
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Overactivity of Alternative Pathway Convertases in Patients With Complement-Mediated Renal Diseases by Michels, Marloes A H M, van de Kar, Nicole C A J, Okrój, Marcin, Blom, Anna M, van Kraaij, Sanne A W, Volokhina, Elena B, van den Heuvel, Lambertus P W J

“…Overactivation of the alternative pathway of the complement system is associated with the renal diseases atypical hemolytic uremic syndrome (aHUS) and C3…”
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Novel Assays to Distinguish Between Properdin-Dependent and Properdin-Independent C3 Nephritic Factors Provide Insight Into Properdin-Inhibiting Therapy by Michels, Marloes A H M, van de Kar, Nicole C A J, van den Bos, Ramon M, van der Velden, Thea J A M, van Kraaij, Sanne A W, Sarlea, Sebastian A, Gracchi, Valentina, Oosterveld, Michiel J S, Volokhina, Elena B, van den Heuvel, Lambertus P W J

“…C3 glomerulopathy (C3G) is an umbrella classification for severe renal diseases characterized by predominant staining for complement component C3 in the…”
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Lack of specific binding of Shiga-like toxin (verocytotoxin) and non-specific interaction of Shiga-like toxin 2 antibody with human polymorphonuclear leucocytes by Geelen, Joyce M., van der Velden, Thea J. A. M., te Loo, D. Maroeska W. M., Boerman, Otto C., van den Heuvel, Lambertus P. W. J., Monnens, Leo A. H.

“…Background. After gastrointestinal infection with Shiga-like toxin (Stx) producing Escherichia coli, the toxin is transported from the intestine to the renal…”
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Mutations in the chloride channel gene CLCNKB as a cause of classic Bartter syndrome by KONRAD, M, VOLLMER, M, GUAY-WOODFORD, L, KNOERS, N. V. A. M, SEYBERTH, H. W, FELDMANN, D, HILDEBRANDT, F, LEMMINK, H. H, VAN DEN HEUVEL, L. P. W. J, JECK, N, VARGAS-POUSSOU, R, LAKINGS, A, RUF, R, DESCHENES, G, ANTIGNAC, C

“…Inherited hypokalemic renal tubulopathies are differentiated into at least three clinical subtypes: (1) the Gitelman variant of Bartter syndrome (GS); (2)…”
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Functional expression of mutations in the human NaCl cotransporter: Evidence for impaired routing mechanisms in gitelman's syndrome by DE JONG, Joke C, VAN DER VLIET, Walter A, VAN DEN HEUVEL, Lambertus P. W. J, WILLEMS, Peter H. G. M, KNOERS, Nine V. A. M, BINDELS, René J. M

“…Gitelman's syndrome is an autosomal recessive renal tubular disorder characterized by hypokalemic metabolic alkalosis, hypomagnesemia, and hypocalciuria. This…”
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Detection of verocytotoxin bound to circulating polymorphonuclear leukocytes of patients with hemolytic uremic syndrome by TE LOO, D. Maroeska W. M, VAN HINSBERGH, Victor W. M, VAN DEN HEUVEL, Lambertus P. W. J, MONNENS, Leo A. H

“…The epidemic form of hemolytic uremic syndrome (HUS) is the most common cause of acute renal failure in children and is characterized by a prodromal phase of…”
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Plasma exchange or immunoadsorption for recurrent focal segmental glomerulosclerosis: clear differences in vitro by Veissi, Susan T, Smeets, Bart, van Wijk, Joanna A E, van der Velden, Thea, van den Heuvel, Lambertus P W J, Schreuder, Michiel F

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Proteinuria and Exposure to Eculizumab in Atypical Hemolytic Uremic Syndrome by Ter Avest, Mendy, Steenbreker, Hilbert, Bouwmeester, Romy N, Duineveld, Caroline, Wijnsma, Kioa L, van den Heuvel, Lambertus P W J, Langemeijer, Saskia M C, Wetzels, Jack F M, van de Kar, Nicole C A J, Ter Heine, Rob

“…Eculizumab is a monoclonal antibody for the treatment of atypical hemolytic uremic syndrome (aHUS). Kidney damage, a common condition in patients with aHUS,…”
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Interactions of Shiga-like toxin with human peripheral blood monocytes by Geelen, Joyce M, van der Velden, Thea J A M, van den Heuvel, Lambertus P W J, Monnens, Leo A H

“…The cytotoxic effect of Shiga-like toxin (Stx; produced by certain Escherichia coli strains) plays a central role in typical hemolytic uremic syndrome (HUS)…”
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