Search Results - "van den Elsen, M"

Exploiting the Reversible Covalent Bonding of Boronic Acids: Recognition, Sensing, and Assembly by Bull, Steven D, Davidson, Matthew G, van den Elsen, Jean M. H, Fossey, John S, Jenkins, A. Toby A, Jiang, Yun-Bao, Kubo, Yuji, Marken, Frank, Sakurai, Kazuo, Zhao, Jianzhang, James, Tony D

“…Boronic acids can interact with Lewis bases to generate boronate anions, and they can also bind with diol units to form cyclic boronate esters. Boronic acid…”
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A Crystal Structure of the Complex Between Human Complement Receptor 2 and Its Ligand C3d by van den Elsen, Jean M. H., Isenman, David E.

“…The interaction of complement receptor 2 (CR2)—which is present on B cells and follicular dendritic cells—with its antigen-bound ligand C3d results in an…”
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Hospital nurses' knowledge regarding older patients: a multicenter study by Derks, Christel T A J, Hutten-van den Elsen, Marjo M G M, Hakvoort, Lysette J, van Mersbergen, Mariëlle P J, Schuurmans, Marieke J, Dikken, Jeroen

“…Nursing care in hospitals increasingly involves older adults. A nursing workforce able to care for the ageing population is therefore critical for ensuring…”
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Ensilication Improves the Thermal Stability of the Tuberculosis Antigen Ag85b and an Sbi-Ag85b Vaccine Conjugate by Wahid, A. A., Doekhie, A., Sartbaeva, A., van den Elsen, J. M. H

“…There is an urgent need for the development of vaccine thermostabilisation methodologies as the maintenance of a continuous and reliable cold chain remains a…”
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The Development of Boronic Acids as Sensors and Separation Tools by Fossey, John S., D'Hooge, Francois, van den Elsen, Jean M. H., Pereira Morais, Marta P., Pascu, Sofia I., Bull, Steven D., Marken, Frank, Jenkins, A. Toby A., Jiang, Yun-Bao, James, Tony D.

“…Synthetic receptors for diols that incorporate boronic acid motifs have been developed as new sensors and separation tools. Utilizing the reversible…”
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Ensilicated tetanus antigen retains immunogenicity: in vivo study and time-resolved SAXS characterization by Doekhie, A., Dattani, R., Chen, Y-C., Yang, Y., Smith, A., Silve, A. P., Koumanov, F., Wells, S. A., Edler, K. J., Marchbank, K. J., Elsen, J. M. H. van den, Sartbaeva, A.

“…Our recently developed ensilication approach can physically stabilize proteins in silica without use of a pre-formed particle matrix. Stabilisation is done by…”
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Analysis of protein glycation using phenylboronate acrylamide gel electrophoresis by Pereira Morais, Marta P, Mackay, Julia D, Bhamra, Savroop K, Buchanan, J. Grant, James, Tony D, Fossey, John S, van den Elsen, Jean M.H

“…The incorporation of the specialized carbohydrate affinity ligand methacrylamido phenylboronic acid in polyacrylamide gels for SDS-PAGE analysis has been…”
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Thermal resilience of ensilicated lysozyme via calorimetric and in vivo analysis by Doekhie, A, Slade, M N, Cliff, L, Weaver, L, Castaing, R, Paulin, J, Chen, Y-C, Edler, K J, Koumanov, F, Marchbank, K J, van den Elsen, J M H, Sartbaeva, A

“…Ensilication is a novel method of protein thermal stabilisation using silica. It uses a modified sol-gel process which tailor fits a protective silica shell…”
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Staphylococcal Complement Evasion Protein Sbi Stabilises C3d Dimers by Inducing an N-Terminal Helix Swap by Dunphy, Rhys W, Wahid, Ayla A, Back, Catherine R, Martin, Rebecca L, Watts, Andrew G, Dodson, Charlotte A, Crennell, Susan J, van den Elsen, Jean M H

“…is an opportunistic pathogen that is able to thwart an effective host immune response by producing a range of immune evasion molecules, including binder of IgG…”
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The guanine-nucleotide-exchange factor BopE from Burkholderia pseudomallei adopts a compact version of the Salmonella SopE/SopE2 fold and undergoes a closed-to-open conformational change upon interaction with Cdc42 by Upadhyay, Abhishek, Wu, Huan-Lin, Williams, Christopher, Field, Terry, Galyov, Edouard E, van den Elsen, Jean M H, Bagby, Stefan

“…BopE is a type III secreted protein from Burkholderia pseudomallei, the aetiological agent of melioidosis, a severe emerging infection. BopE is a GEF…”
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From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence? by Priest, Nicholas K., Rudkin, Justine K., Feil, Edward J., van den Elsen, Jean M. H., Cheung, Ambrose, Peacock, Sharon J., Laabei, Maisem, Lucks, David A., Recker, Mario, Massey, Ruth C.

“…Predicting the virulence of a particular bacterial strain is a complex task that currently cannot be achieved from genome sequence data alone. In this Opinion…”
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Insights Into the Structure-Function Relationships of Dimeric C3d Fragments by Wahid, Ayla A, Dunphy, Rhys W, Macpherson, Alex, Gibson, Beth G, Kulik, Liudmila, Whale, Kevin, Back, Catherine, Hallam, Thomas M, Alkhawaja, Bayan, Martin, Rebecca L, Meschede, Ingrid, Laabei, Maisem, Lawson, Alastair D G, Holers, V Michael, Watts, Andrew G, Crennell, Susan J, Harris, Claire L, Marchbank, Kevin J, van den Elsen, Jean M H

“…Cleavage of C3 to C3a and C3b plays a central role in the generation of complement-mediated defences. Although the thioester-mediated surface deposition of C3b…”
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The allosteric modulation of complement C5 by knob domain peptides by Macpherson, Alex, Laabei, Maisem, Ahdash, Zainab, Graewert, Melissa A, Birtley, James R, Schulze, Monika-Sarah Ed, Crennell, Susan, Robinson, Sarah A, Holmes, Ben, Oleinikovas, Vladas, Nilsson, Per H, Snowden, James, Ellis, Victoria, Mollnes, Tom Eirik, Deane, Charlotte M, Svergun, Dmitri, Lawson, Alastair Dg, van den Elsen, Jean Mh

“…Bovines have evolved a subset of antibodies with ultra-long heavy chain complementarity determining regions that harbour cysteine-rich knob domains. To produce…”
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Utilization of Staphylococcal Immune Evasion Protein Sbi as a Novel Vaccine Adjuvant by Yang, Yi, Back, Catherine R, Gräwert, Melissa A, Wahid, Ayla A, Denton, Harriet, Kildani, Rebecca, Paulin, Joshua, Wörner, Kristin, Kaiser, Wolgang, Svergun, Dmitri I, Sartbaeva, Asel, Watts, Andrew G, Marchbank, Kevin J, van den Elsen, Jean M H

“…Co-ligation of the B cell antigen receptor with complement receptor 2 on B-cells via a C3d-opsonised antigen complex significantly lowers the threshold…”
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Why are the 2-oxoacid dehydrogenase complexes so large? Generation of an active trimeric complex by Marrott, Nia L, Marshall, Jacqueline J T, Svergun, Dmitri I, Crennell, Susan J, Hough, David W, van den Elsen, Jean M H, Danson, Michael J

“…The four-component polypeptides of the 2-oxoacid dehydrogenase complex from the thermophilic archaeon Thermoplasma acidophilum assemble to give an active…”
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Interaction of Human Complement with Sbi, a Staphylococcal Immunoglobulin-binding Protein: INDICATIONS OF A NOVEL MECHANISM OF COMPLEMENT EVASION BY STAPHYLOCOCCUS AUREUS by Burman, Julia D, Leung, Elisa, Atkins, Karen L, O'Seaghdha, Maghnus N, Lango, Lea, Bernadó, Pau, Bagby, Stefan, Svergun, Dmitri I, Foster, Timothy J, Isenman, David E, van den Elsen, Jean M.H

“…Staphylococcal immunoglobulin-binding protein, Sbi, is a 436-residue protein produced by many strains of Staphylococcus aureus. It was previously characterized…”
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Mutational Analyses Reveal that the Staphylococcal Immune Evasion Molecule Sbi and Complement Receptor 2 (CR2) Share Overlapping Contact Residues on C3d: Implications for the Controversy Regarding the CR2/C3d Cocrystal Structure by Isenman, David E, Leung, Elisa, Mackay, Julia D, Bagby, Stefan, van den Elsen, Jean M. H

“…We recently characterized an interaction between the Staphylococcus aureus immune evasion molecule Staphylococcus aureus binder of Ig (Sbi) and complement C3,…”
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Analysis of protein glycation using fluorescent phenylboronate gel electrophoresis by Pereira Morais, Marta P., Marshall, Dominic, Flower, Stephen E., Caunt, Christopher J., James, Tony D., Williams, Robert J., Waterfield, Nicholas R., van den Elsen, Jean M. H.

“…Glycated proteins are important biomarkers for age-related disorders, however their analysis is challenging because of the complexity of the…”
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Structure-Function Analysis of the C3 Binding Region of Staphylococcus aureus Immune Subversion Protein Sbi by Upadhyay, Abhishek, Burman, Julia D., Clark, Elizabeth A., Leung, Elisa, Isenman, David E., van den Elsen, Jean M.H., Bagby, Stefan

“…Among the recently discovered Staphylococcus aureus immune evasion proteins, Sbi is unique in its ability to interact with components of both the adaptive and…”
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Homology modelling of Drosophila cytochrome P450 enzymes associated with insecticide resistance by Jones, Robert T, Bakker, Saskia E, Stone, Deborah, Shuttleworth, Sally N, Boundy, Sam, McCart, Caroline, Daborn, Phillip J, ffrench-Constant, Richard H, van den Elsen, Jean MH

“…BACKGROUND: Overexpression of the cytochrome P450 gene Cyp6g1 confers resistance against DDT and a broad range of other insecticides in Drosophila melanogaster…”
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