Search Results - "van den Broek, Niels J. F."

Convergence of immune escape strategies highlights plasticity of SARS-CoV-2 spike by Yu, Xiaodi, Juraszek, Jarek, Rutten, Lucy, Bakkers, Mark J G, Blokland, Sven, Melchers, Jelle M, van den Broek, Niels J F, Verwilligen, Annemiek Y W, Abeywickrema, Pravien, Vingerhoets, Johan, Neefs, Jean-Marc, Bakhash, Shah A Mohamed, Roychoudhury, Pavitra, Greninger, Alex, Sharma, Sujata, Langedijk, Johannes P M

“…The global spread of the SARS-CoV-2 virus has resulted in emergence of lineages which impact the effectiveness of immunotherapies and vaccines that are based…”
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Mdm2 induces mono-ubiquitination of FOXO4 by Brenkman, Arjan B, de Keizer, Peter L J, van den Broek, Niels J F, Jochemsen, A G, Burgering, Boudewijn M Th

“…The Forkhead box O (FOXO) class of transcription factors are involved in the regulation of several cellular responses including cell cycle progression and…”
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The Adipogenic Acetyltransferase Tip60 Targets Activation Function 1 of Peroxisome Proliferator-Activated Receptor γ by van Beekum, Olivier, Brenkman, Arjan B, Grøntved, Lars, Hamers, Nicole, van den Broek, Niels J. F, Berger, Ruud, Mandrup, Susanne, Kalkhoven, Eric

“…The transcription factor peroxisome proliferator-activated receptor γ (PPARγ) plays a key role in the regulation of lipid and glucose metabolism in adipocytes,…”
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SIRT1 mediates FOXA2 breakdown by deacetylation in a nutrient-dependent manner by van Gent, Rogier, Di Sanza, Claudio, van den Broek, Niels J F, Fleskens, Veerle, Veenstra, Aukje, Stout, Gerdine J, Brenkman, Arjan B

“…The Forkhead transcription factor FOXA2 plays a fundamental role in controlling metabolic homeostasis in the liver during fasting. The precise molecular…”
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Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis by Cardaci, Simone, Zheng, Liang, MacKay, Gillian, van den Broek, Niels J. F., MacKenzie, Elaine D., Nixon, Colin, Stevenson, David, Tumanov, Sergey, Bulusu, Vinay, Kamphorst, Jurre J., Vazquez, Alexei, Fleming, Stewart, Schiavi, Francesca, Kalna, Gabriela, Blyth, Karen, Strathdee, Douglas, Gottlieb, Eyal

“…Succinate dehydrogenase (SDH) is a heterotetrameric nuclear-encoded complex responsible for the oxidation of succinate to fumarate in the tricarboxylic acid…”
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Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress by Schug, Zachary T., Peck, Barrie, Jones, Dylan T., Zhang, Qifeng, Grosskurth, Shaun, Alam, Israt S., Goodwin, Louise M., Smethurst, Elizabeth, Mason, Susan, Blyth, Karen, McGarry, Lynn, James, Daniel, Shanks, Emma, Kalna, Gabriela, Saunders, Rebecca E., Jiang, Ming, Howell, Michael, Lassailly, Francois, Thin, May Zaw, Spencer-Dene, Bradley, Stamp, Gordon, van den Broek, Niels J.F., Mackay, Gillian, Bulusu, Vinay, Kamphorst, Jurre J., Tardito, Saverio, Strachan, David, Harris, Adrian L., Aboagye, Eric O., Critchlow, Susan E., Wakelam, Michael J.O., Schulze, Almut, Gottlieb, Eyal

“…A functional genomics study revealed that the activity of acetyl-CoA synthetase 2 (ACSS2) contributes to cancer cell growth under low-oxygen and lipid-depleted…”
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Regulation of histone H3K4 tri-methylation and PAF complex recruitment by the Ccr4-Not complex by Mulder, Klaas W, Brenkman, Arjan B, Inagaki, Akiko, van den Broek, Niels J.F, Marc Timmers, H. Th

“…Efficient transcription is linked to modification of chromatin. For instance, tri-methylation of lysine 4 on histone H3 (H3K4) strongly correlates with…”
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Metabolic engineering of a carbapenem antibiotic synthesis pathway in Escherichia coli by Shomar, Helena, Gontier, Sophie, van den Broek, Niels J. F., Tejeda Mora, Héctor, Noga, Marek J., Hagedoorn, Peter-Leon, Bokinsky, Gregory

“…Carbapenems, a family of β-lactam antibiotics, are among the most powerful bactericidal compounds in clinical use. However, as rational engineering of native…”
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Posttranslational Control of PlsB Is Sufficient To Coordinate Membrane Synthesis with Growth in Escherichia coli by Noga, Marek J., Büke, Ferhat, van den Broek, Niels J. F., Imholz, Nicole C. E., Scherer, Nicole, Yang, Flora, Bokinsky, Gregory

“…How do bacterial cells grow without breaking their membranes? Although the biochemistry of fatty acid and membrane synthesis is well known, how membrane…”
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Calibrating the Bacterial Growth Rate Speedometer: A Re-evaluation of the Relationship Between Basal ppGpp, Growth, and RNA Synthesis in Escherichia coli by Imholz, Nicole C. E., Noga, Marek J., van den Broek, Niels J. F., Bokinsky, Gregory

“…The molecule guanosine tetraphophosphate (ppGpp) is most commonly considered an alarmone produced during acute stress. However, ppGpp is also present at low…”
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Phosphorylation of Not4p Functions Parallel to BUR2 to Regulate Resistance to Cellular Stresses in Saccharomyces cerevisiae by Lau, Nga-Chi, Mulder, Klaas W, Brenkman, Arjan B, Mohammed, Shabaz, Broek, Niels J.F. van den, Heck, Albert J.R, Timmers, H.Th. Marc

“…Background: The evolutionarily conserved Ccr4-Not and Bur1/2 kinase complexes are functionally related in Saccharomyces cerevisiae. In this study, we further…”
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Insulin/IGF‐1‐mediated longevity is marked by reduced protein metabolism by Stout, Gerdine J, Stigter, Edwin C A, Essers, Paul B, Mulder, Klaas W, Kolkman, Annemieke, Snijders, Dorien S, van den Broek, Niels J F, Betist, Marco C, Korswagen, Hendrik C, MacInnes, Alyson W, Brenkman, Arjan B

“…Mutations in the daf‐2 gene of the conserved Insulin/Insulin‐like Growth Factor (IGF‐1) pathway double the lifespan of the nematode Caenorhabditis elegans …”
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The serine/threonine phosphatase PPM1B (PP2Cβ) selectively modulates PPARγ activity by Tasdelen, Ismayil, van Beekum, Olivier, Gorbenko, Olena, Fleskens, Veerle, van den Broek, Niels J F, Koppen, Arjen, Hamers, Nicole, Berger, Ruud, Coffer, Paul J, Brenkman, Arjan B, Kalkhoven, Eric

“…Reversible phosphorylation is a widespread molecular mechanism to regulate the function of cellular proteins, including transcription factors. Phosphorylation…”
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A protocol for quantifying lipid peroxidation in cellular systems by F2-isoprostane analysis by Labuschagne, Christiaan F, van den Broek, Niels J F, Postma, Pjotr, Berger, Ruud, Brenkman, Arjan B

“…Cellular systems are essential model systems to study reactive oxygen species and oxidative damage but there are widely accepted technical difficulties with…”
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Modulating the therapeutic response of tumours to dietary serine and glycine starvation by Maddocks, Oliver D. K., Athineos, Dimitris, Cheung, Eric C., Lee, Pearl, Zhang, Tong, van den Broek, Niels J. F., Mackay, Gillian M., Labuschagne, Christiaan F., Gay, David, Kruiswijk, Flore, Blagih, Julianna, Vincent, David F., Campbell, Kirsteen J., Ceteci, Fatih, Sansom, Owen J., Blyth, Karen, Vousden, Karen H.

“…Dependence on exogenous serine means that tumour growth is restricted in mice on a low-serine diet; this effect on tumour growth can be amplified by…”
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DNA damage repair protein Ku70 interacts with FOXO4 to coordinate a conserved cellular stress response by Brenkman, Arjan B, van den Broek, Niels J.F, de Keizer, Peter L.J, van Gent, Dik C, Burgering, Boudewijn M.T

“…In this study, we searched for proteins regulating the tumor suppressor and life-span regulator FOXO4. Through an unbiased tandem-affinity purification…”
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Serine, but Not Glycine, Supports One-Carbon Metabolism and Proliferation of Cancer Cells by Labuschagne, Christiaan F., van den Broek, Niels J.F., Mackay, Gillian M., Vousden, Karen H., Maddocks, Oliver D.K.

“…Previous work has shown that some cancer cells are highly dependent on serine/glycine uptake for proliferation. Although serine and glycine can be…”
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Analysis of Cell Metabolism Using LC-MS and Isotope Tracers by Mackay, Gillian M, Zheng, Liang, van den Broek, Niels J F, Gottlieb, Eyal

“…Here we discuss our methods to analyze small polar compounds involved in central carbon metabolism using LC-MS. Methods described include sample extraction…”
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Mps1 Phosphorylates Borealin to Control Aurora B Activity and Chromosome Alignment by Jelluma, Nannette, Brenkman, Arjan B., van den Broek, Niels J.F., Cruijsen, Carin W.A., van Osch, Maria H.J., Lens, Susanne M.A., Medema, René H., Kops, Geert J.P.L.

“…Maintenance of chromosomal stability relies on coordination between various processes that are critical for proper chromosome segregation in mitosis. Here we…”
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Activation of Forkhead Box O Transcription Factors by Oncogenic BRAF Promotes p21cip1-Dependent Senescence by DE KEIZER, Peter L. J, PACKER, Leisl M, SZYPOWSKA, Anna A, RIEDL-POLDERMAN, Paulien E, VAN DEN BROEK, Niels J. F, DE BRUIN, Alain, DANSEN, Tobias B, MARAIS, Richard, BRENKMAN, Arjan B, BURGERING, Boudewijn M. T

“…Oncogene-induced senescence (OIS) is a potent tumor-suppressive mechanism that is thought to come at the cost of aging. The Forkhead box O (FOXO) transcription…”
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