Search Results - "van den Brink, Susanne C"
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An in vitro model of early anteroposterior organization during human development
Published in Nature (London) (18-06-2020)“…The body plan of the mammalian embryo is shaped through the process of gastrulation, an early developmental event that transforms an isotropic group of cells…”
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Twisting of the zebrafish heart tube during cardiac looping is a tbx5-dependent and tissue-intrinsic process
Published in eLife (10-08-2021)“…Organ laterality refers to the left-right asymmetry in disposition and conformation of internal organs and is established during embryogenesis. The heart is…”
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Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids
Published in Nature (London) (18-06-2020)“…Gastruloids are three-dimensional aggregates of embryonic stem cells that display key features of mammalian development after implantation, including…”
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3D gastruloids: a novel frontier in stem cell-based in vitro modeling of mammalian gastrulation
Published in Trends in cell biology (01-09-2021)“…3D gastruloids, aggregates of embryonic stem cells that recapitulate key aspects of gastrula-stage embryos, have emerged as a powerful tool to study the early…”
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Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations
Published in Nature methods (01-10-2017)Get full text
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Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells
Published in Development (Cambridge) (01-11-2014)“…Mouse embryonic stem cells (mESCs) are clonal populations derived from preimplantation mouse embryos that can be propagated in vitro and, when placed into…”
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Modelling human embryogenesis: embryo-like structures spark ethical and policy debate
Published in Human reproduction update (01-11-2020)“…Studying the human peri-implantation period remains hindered by the limited accessibility of the in vivo environment and scarcity of research material. As…”
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Haematopoietic development and HSC formation in vitro: promise and limitations of gastruloid models
Published in Emerging topics in life sciences (18-12-2023)“…Haematopoietic stem cells (HSCs) are the most extensively studied adult stem cells. Yet, six decades after their first description, reproducible and…”
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Publisher Correction: Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids
Published in Nature (London) (01-03-2020)“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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