Search Results - "van den Brink, D.M."

Metabolism of phytol to phytanic acid in the mouse, and the role of PPARα in its regulation by Gloerich, J., van den Brink, D.M., Ruiter, J. P.N., van Vlies, N., Vaz, F.M., Wanders, R. J.A., Ferdinandusse, S.

“…Phytol, a branched-chain fatty alcohol, is the naturally occurring precursor of phytanic and pristanic acid, branched-chain fatty acids that are both ligands…”
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Adaptive Preconditioning in Neurological Diseases – Therapeutic Insights from Proteostatic Perturbations by Mollereau, B, Rzechorzek, NM, Roussel, BD, Sedru, M, Van den Brink, D, Bailly-Maitre, B, Palladino, F, Medinas, D.B, Domingos, PM, Hunot, S, Chandran, S, Birman, S, Baron, T, Vivien, D, Duarte, CB, Ryoo, HD, Steller, H, Urano, F, Chevet, E, Kroemer, G, Ciechanover, A, Calabrese, EJ, Kaufman, RJ, Hetz, C

“…Abstract In neurological disorders, both acute and chronic neural stress can disrupt cellular proteostasis, resulting in the generation of pathological…”
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Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation by Gloerich, J., Ruiter, J.P.N., van den Brink, D.M., Ofman, R., Ferdinandusse, S., Wanders, R.J.A.

“…Phytol is a naturally occurring precursor of phytanic acid. The last step in the conversion of phytol to phytanoyl-CoA is the reduction of phytenoyl-CoA…”
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Identification of Pristanal Dehydrogenase Activity in Peroxisomes: Conclusive Evidence That the Complete Phytanic Acid α-Oxidation Pathway Is Localized in Peroxisomes by Jansen, G.A., van den Brink, D.M., Ofman, R., Draghici, O., Dacremont, G., Wanders, R.J.A.

“…Phytanic acid (3,7,11,15-tetramethylhexadecanoic acid) is a branched-chain fatty acid which, due to the methyl-group at the 3-position, can not undergo…”
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