Search Results - "van den Bosch, Thierry P P"
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Development of an Ex Vivo Functional Assay for Prediction of Irradiation Related Toxicity in Healthy Oral Mucosa Tissue
Published in International journal of molecular sciences (01-07-2024)“…Radiotherapy in the head-and-neck area is one of the main curative treatment options. However, this comes at the cost of varying levels of normal tissue…”
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Organ-specific genome diversity of replication-competent SARS-CoV-2
Published in Nature communications (16-11-2021)“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is not always confined to the respiratory system, as it impacts people on a broad…”
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Issues with RNF43 antibodies to reliably detect intracellular location
Published in PloS one (06-04-2023)“…RNF43 is an important negative regulator of β-catenin signaling by removing Wnt-receptors from the membrane. It is often mutated in cancers, leading to…”
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Periostin Is Expressed by Pericytes and Is Crucial for Angiogenesis in Glioma
Published in Journal of neuropathology and experimental neurology (01-08-2020)“…Abstract The expression of the matricellular protein periostin has been associated with glioma progression. In previous work we found an association of…”
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Author Correction: Organ-specific genome diversity of replication-competent SARS-CoV-2
Published in Nature communications (21-10-2022)Get full text
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The deleted in oral cancer (DOC1 aka CDK2AP1) tumor suppressor gene is downregulated in oral squamous cell carcinoma by multiple microRNAs
Published in Cell death & disease (22-05-2023)“…Cyclin-dependent kinase 2-associated protein 1 ( CDK2AP1 ; also known as deleted in oral cancer or DOC1 ) is a tumor suppressor gene known to play functional…”
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Mpox virus infects and injures human kidney organoids, but responding to antiviral treatment
Published in Cell discovery (03-04-2023)Get full text
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Cryo-Gel embedding compound for renal biopsy biobanking
Published in Scientific reports (24-10-2019)“…Optimal preservation and biobanking of renal tissue is vital for good diagnostics and subsequent research. Optimal cutting temperature (OCT) compound is a…”
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Evaluation of Immunohistochemical Markers, CK17 and SOX2, as Adjuncts to p53 for the Diagnosis of Differentiated Vulvar Intraepithelial Neoplasia (dVIN)
Published in Pharmaceuticals (Basel, Switzerland) (02-04-2021)“…Histological diagnosis of differentiated vulvar intraepithelial neoplasia (dVIN), the precursor of human papillomavirus (HPV)-independent vulvar squamous cell…”
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A Novel Technique for the Generation of Substantial Numbers of Functional Resident T Cells from Kidney Tissue
Published in Cells (Basel, Switzerland) (18-07-2022)“…Studying functionality and antigen-specificity of resident kidney T cells derived from a kidney biopsy is hampered by the lack of sufficient numbers of T cells…”
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Identification of Early-Onset Metastasis in SF3B1 Mutated Uveal Melanoma
Published in Cancers (08-02-2022)“…Approximately 25% of all uveal melanoma (UM) contain driver mutations in the gene encoding the spliceosome factor , and whilst patients with such mutations…”
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Granulomas in Common Variable Immunodeficiency Display Different Histopathological Features Compared to Other Granulomatous Diseases
Published in Journal of clinical immunology (01-12-2025)“…Granulomatous disease affects up to 20% of patients with Common Variable Immunodeficiency (CVID). Granulomas are comprised of highly activated immune cells,…”
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Transcriptomic Properties of HER2+ Ductal Carcinoma In Situ of the Breast Associate with Absence of Immune Cells
Published in Biology (Basel, Switzerland) (12-08-2021)“…The identification of transcriptomic alterations of HER2+ ductal carcinoma in situ (DCIS) that are associated with the density of tumor-infiltrating…”
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Clinical significance of immunohistochemistry for detection of BAP1 mutations in uveal melanoma
Published in Modern pathology (01-10-2014)“…Uveal melanoma is a lethal cancer with a strong propensity to metastasize. Limited therapeutic options are available once the disease has disseminated. A…”
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Identification of Blood–Brain Barrier-Associated Proteins in the Human Brain
Published in Journal of proteome research (01-01-2021)“…The blood–brain barrier (BBB) is essential for cerebral homeostasis and controls the selective passage of molecules traveling in and out of the brain. Despite…”
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Ductal carcinoma in situ of the breast: immune cell composition according to subtype
Published in Modern pathology (01-02-2020)“…Ductal carcinoma in situ of the breast includes several subtypes with a divergent biological behavior. Data regarding the composition of ductal carcinoma in…”
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Immune-Related Circulating miR-125b-5p and miR-99a-5p Reveal a High Recurrence Risk Group of Pancreatic Cancer Patients after Tumor Resection
Published in Applied sciences (02-11-2019)“…Clinical follow-up aided by changes in the expression of circulating microRNAs (miRs) may improve prognostication of pancreatic ductal adenocarcinoma (PDAC)…”
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Transcriptomic Analysis of Livers of Inactive Carriers of Hepatitis B Virus With Distinct Expression of Hepatitis B Surface Antigen
Published in The Journal of infectious diseases (15-03-2022)“…Abstract Inactive carrier phases in chronic hepatitis B virus (HBV) infection present minimal liver disease and HBV replication activity suggesting partial…”
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Targeting the Monocyte-Macrophage Lineage in Solid Organ Transplantation
Published in Frontiers in immunology (16-02-2017)“…There is an unmet clinical need for immunotherapeutic strategies that specifically target the active immune cells participating in the process of rejection…”
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Prediction of molecular subclasses of uveal melanoma by deep learning using routine haematoxylin–eosin‐stained tissue slides
Published in Histopathology (01-12-2024)“…Aims Uveal melanoma has a high propensity to metastasize. Prognosis is associated with specific driver mutations and copy number variations, and these can only…”
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