Search Results - "van den Bosch, Sandra M."

In Vivo Chemistry for Pretargeted Tumor Imaging in Live Mice by Rossin, Raffaella, Renart Verkerk, Pascal, van den Bosch, Sandra M, Vulders, Roland C.M, Verel, Iris, Lub, Johan, Robillard, Marc S

“…Mice and men: An antibody conjugate with trans‐cyclooctene was administered to tumor‐bearing mice, and the resulting chemically tagged tumors were subsequently…”
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Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations by Derks, Sarah, Postma, Cindy, Carvalho, Beatriz, van den Bosch, Sandra M., Moerkerk, Peter T.M., Herman, James G., Weijenberg, Matty P., de Bruïne, Adriaan P., Meijer, Gerrit A., van Engeland, Manon

“…Colorectal cancer (CRC) is a complex and heterogeneous disease in which genomic instability and DNA promoter methylation play important roles. The aim of this…”
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Diels-Alder reaction for tumor pretargeting: in vivo chemistry can boost tumor radiation dose compared with directly labeled antibody by Rossin, Raffaella, Läppchen, Tilman, van den Bosch, Sandra M, Laforest, Richard, Robillard, Marc S

“…Current pretargeting systems use noncovalent biologic interactions, which are prone to immunogenicity. We previously developed a novel approach based on the…”
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Promoter CpG island hypermethylation- and H3K9me3 and H3K27me3-mediated epigenetic silencing targets the deleted in colon cancer (DCC) gene in colorectal carcinogenesis without affecting neighboring genes on chromosomal region 18q21 by Derks, Sarah, Bosch, Linda J.W., Niessen, Hanneke E.C., Moerkerk, Peter T.M., van den Bosch, Sandra M., Carvalho, Beatriz, Mongera, Sandra, Voncken, J.Willem, Meijer, Gerrit A., de Bruïne, Adriaan P., Herman, James G., van Engeland, Manon

“…Chromosomal loss of 18q21 is a frequent event in colorectal cancer (CRC) development, suggesting that this region harbors tumor suppressor genes (TSGs)…”
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Highly Reactive trans-Cyclooctene Tags with Improved Stability for Diels–Alder Chemistry in Living Systems by Rossin, Raffaella, van den Bosch, Sandra M, ten Hoeve, Wolter, Carvelli, Marco, Versteegen, Ron M, Lub, Johan, Robillard, Marc S

“…One of the challenges of pretargeted radioimmunotherapy, which centers on the capture of a radiolabeled probe by a preinjected tumor-bound antibody, is the…”
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Diabody Pretargeting with Click Chemistry In Vivo by van Duijnhoven, Sander M J, Rossin, Raffaella, van den Bosch, Sandra M, Wheatcroft, Michael P, Hudson, Peter J, Robillard, Marc S

“…Radioimmunotherapy and nuclear imaging (immuno-PET/SPECT) of cancer with radiometal-labeled antibody fragments or peptides is hampered by low tumor-to-kidney…”
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Trans-Cyclooctene Tag with Improved Properties for Tumor Pretargeting with the Diels–Alder Reaction by Rossin, Raffaella, van Duijnhoven, Sander M. J, Läppchen, Tilman, van den Bosch, Sandra M, Robillard, Marc S

“…Radioimmunotherapy (RIT) of solid tumors is hampered by low tumor-to-nontumor (T/NT) ratios of the radiolabeled monoclonal antibodies resulting in low tumor…”
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N-Myc Downstream-Regulated Gene 4 (NDRG4): A Candidate Tumor Suppressor Gene and Potential Biomarker for Colorectal Cancer by Melotte, Veerle, Lentjes, Marjolein H. F. M., van den Bosch, Sandra M., Hellebrekers, Debby M. E. I., de Hoon, Joep P. J., Wouters, Kim A. D., Daenen, Kathleen L. J., Partouns-Hendriks, Iris E. J. M., Stessels, Filip, Louwagie, Joost, Smits, Kim M., Weijenberg, Matty P., Sanduleanu, Silvia, Khalid-de Bakker, Carolina A. J., Oort, Frank A., Meijer, Gerrit A., Jonkers, Daisy M. A. E., Herman, James G., de Bruïne, Adriaan P., van Engeland, Manon

“…Background Identification of hypermethylated tumor suppressor genes in body fluids is an appealing strategy for the noninvasive detection of colorectal cancer…”
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GATA4 and GATA5 are Potential Tumor Suppressors and Biomarkers in Colorectal Cancer by Hellebrekers, Debby M E I, Lentjes, Marjolein H F M, van den Bosch, Sandra M, Melotte, Veerle, Wouters, Kim A D, Daenen, Kathleen L J, Smits, Kim M, Akiyama, Yoshimitsu, Yuasa, Yasuhito, Sanduleanu, Silvia, Khalid-de Bakker, Carolina A J, Jonkers, Daisy, Weijenberg, Matty P, Louwagie, Joost, van Criekinge, Wim, Carvalho, Beatriz, Meijer, Gerrit A, Baylin, Stephen B, Herman, James G, de Bruïne, Adriaan P, van Engeland, Manon

“…Purpose: The transcription factors GATA4 and GATA5 are involved in gastrointestinal development and are inactivated by promoter hypermethylation in colorectal…”
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Promoter methylation precedes chromosomal alterations in colorectal cancer development by Derks, Sarah, Postma, Cindy, Moerkerk, Peter T M, van den Bosch, Sandra M, Carvalho, Beatriz, Hermsen, Mario A J A, Giaretti, Walter, Herman, James G, Weijenberg, Matty P, de Bruïne, Adriaan P, Meijer, Gerrit A, van Engeland, Manon

“…Colorectal cancers are characterized by genetic and epigenetic alterations. This study aimed to explore the timing of promoter methylation and relationship…”
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Tumor pretargeting with Diels–Alder: A TCO derivative with improved properties by Rossin, Raffaella, van Duijnhoven, Sander M.J, van den Bosch, Sandra M, Robillard, Marc S

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Tumor pretargeting with antibody fragments and the Diels–Alder reaction by van Duijnhoven, Sander M.J, Rossin, Raffaella, van den Bosch, Sandra M, Wheatcroft, Michael, Hudson, Peter, Robillard, Marc S

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A new tumor pretargeting approach based on a bio-orthogonal chemical reaction by Rossin, Raffaella, Verkerk, Pascal Renart, van den Bosch, Sandra M, Vulders, Roland C.M, Verel, Iris, Lub, Johan, Robillard, Marc S

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In Vivo Chemistry for Pretargeted Tumor Imaging in Live Mice by Rossin, Raffaella, Renart Verkerk, Pascal, van den Bosch, Sandra M., Vulders, Roland C. M., Verel, Iris, Lub, Johan, Robillard, Marc S.

“…Wie sieht's aus in der Maus? Ein trans‐Cycloocten‐Antikörper‐Konjugat wurde Tumormäusen verabreicht. Die derart chemisch markierten Tumore wurden dann mit…”
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Abstract 4552: Pretargeted radioimmunoimaging and -therapy in tumor-bearing mice using a bioorthogonal reaction by Rossin, Raffaella, Verkerk, Pascal Renart, van den Bosch, Sandra M., Vulders, Roland Cm, Verel, Iris, Lub, Johan, Robillard, Marc S.

“…Abstract A major challenge of radioimmunotherapy (RIT) of cancer is to enhance the nuclear radiation dose delivered to the tumor while minimizing the dose in…”
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Inside Cover: In Vivo Chemistry for Pretargeted Tumor Imaging in Live Mice (Angew. Chem. Int. Ed. 19/2010) by Rossin, Raffaella, Renart Verkerk, Pascal, van den Bosch, Sandra M., Vulders, Roland C. M., Verel, Iris, Lub, Johan, Robillard, Marc S.

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Innentitelbild: In Vivo Chemistry for Pretargeted Tumor Imaging in Live Mice (Angew. Chem. 19/2010) by Rossin, Raffaella, Renart Verkerk, Pascal, van den Bosch, Sandra M., Vulders, Roland C. M., Verel, Iris, Lub, Johan, Robillard, Marc S.

“…Diels‐Alder‐Reaktionen mit inversem Elektronenbedarf können effizient in lebenden Tieren ausgeführt werden. In ihrer Zuschrift auf S. 3447 ff. beschreiben M…”
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In Vivo Chemistry for Pretargeted Tumor Imaging in Live Mice by Rossin, Raffaella, Renart Verkerk, Pascal, van den Bosch, Sandra M., Vulders, Roland C. M., Verel, Iris, Lub, Johan, Robillard, Marc S.

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Innentitelbild: In Vivo Chemistry for Pretargeted Tumor Imaging in Live Mice (Angew. Chem. 19/2010) by Rossin, Raffaella, Renart Verkerk, Pascal, van den Bosch, Sandra M., Vulders, Roland C. M., Verel, Iris, Lub, Johan, Robillard, Marc S.

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