Search Results - "van den Bosch, Marion T.J"

Coordinated Membrane Ballooning and Procoagulant Spreading in Human Platelets by Agbani, Ejaife O, van den Bosch, Marion T.J, Brown, Ed, Williams, Christopher M, Mattheij, Nadine J.A, Cosemans, Judith M.E.M, Collins, Peter W, Heemskerk, Johan W.M, Hers, Ingeborg, Poole, Alastair W

“…BACKGROUND—Platelets are central to the process of hemostasis, rapidly aggregating at sites of blood vessel injury and acting as coagulation nidus sites. On…”
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INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment and induction of immunogenic cell death by Duurland, Chantal L, Gunst, Thijs de, Boer, Harm C den, Bosch, Marion T J van den, Telford, Bryony J, Vos, Rogier M, Xie, Xiaolei, Zang, Mingfa, Wang, Fang, Shao, Yingying, An, Xiaoyu, Wang, Jingjing, Cai, Jie, Bourré, Ludovic, Pinxteren, Laurens A H van, Schaapveld, Roel Q J, Janicot, Michel, Yahyanejad, Sanaz

“…microRNAs (miRNAs) are small, non-coding RNAs that regulate expression of multiple genes. MiR-193a-3p functions as a tumor suppressor in many cancer types, but…”
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Platelet-Associated Matrix Metalloproteinases Regulate Thrombus Formation and Exert Local Collagenolytic Activity by Mastenbroek, Tom G, Feijge, Marion A.H, Kremers, Romy M.W, van den Bosch, Marion T.J, Swieringa, Frauke, De Groef, Lies, Moons, Lieve, Bennett, Cavan, Ghevaert, Cedric, Johnson, Jason L, van der Meijden, Paola E.J, Cosemans, Judith M.E.M

“…OBJECTIVE—Platelets are increasingly implicated in processes beyond hemostasis and thrombosis, such as vascular remodeling. Members of the matrix…”
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Transcriptome-wide analysis reveals insight into tumor suppressor functions of 1B3, a novel synthetic miR-193a-3p mimic by van den Bosch, Marion T.J., Yahyanejad, Sanaz, Alemdehy, Mir Farshid, Telford, Bryony J., de Gunst, Thijs, den Boer, Harm C., Vos, Rogier M., Stegink, Marieke, van Pinxteren, Laurens A.H., Schaapveld, Roel Q.J., Janicot, Michel

“…Emerging data show that microRNA 193a-3p (miR-193a-3p) has a suppressive role in many cancers and is often downregulated in tumors, as compared to surrounding…”
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Aquaporin-1 regulates platelet procoagulant membrane dynamics and in vivo thrombosis by Agbani, Ejaife O., Williams, Christopher M., Li, Yong, van den Bosch, Marion T.J., Moore, Samantha F., Mauroux, Adele, Hodgson, Lorna, Verkman, Alan S., Hers, Ingeborg, Poole, Alastair W.

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Loss of the mitochondrial kinase PINK1 does not alter platelet function by Walsh, Tony G., van den Bosch, Marion T. J., Lewis, Kirsty E., Williams, Christopher M., Poole, Alastair W.

“…PTEN-induced putative kinase (PINK) 1 is regarded as a master regulator of cellular mitophagy such that loss of function mutations contribute to early onset…”
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Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology by Telford, Bryony J, Yahyanejad, Sanaz, de Gunst, Thijs, den Boer, Harm C, Vos, Rogier M, Stegink, Marieke, van den Bosch, Marion T J, Alemdehy, Mir Farshid, van Pinxteren, Laurens A H, Schaapveld, Roel Q J, Janicot, Michel

“…Compelling evidence demonstrates that miR-193a-3p is a tumor suppressor microRNA in many cancer types, and its reduced expression is linked to cancer…”
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Aquaporin-1 regulates platelet procoagulant membrane dynamics and in vivo thrombosis by Agbani, Ejaife O, Williams, Christopher M, Li, Yong, van den Bosch, Marion Tj, Moore, Samantha F, Mauroux, Adele, Hodgson, Lorna, Verkman, Alan S, Hers, Ingeborg, Poole, Alastair W

“…In response to collagen stimulation, platelets use a coordinated system of fluid entry to undergo membrane ballooning, procoagulant spreading, and…”
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Dual Regulation of Glycogen Synthase Kinase 3 (GSK3)α/β by Protein Kinase C (PKC)α and Akt Promotes Thrombin-mediated Integrin αIIbβ3 Activation and Granule Secretion in Platelets by Moore, Samantha F., van den Bosch, Marion T.J., Hunter, Roger W., Sakamoto, Kei, Poole, Alastair W., Hers, Ingeborg

“…Glycogen synthase kinase-3 is a Ser/Thr kinase, tonically active in resting cells but inhibited by phosphorylation of an N-terminal Ser residue (Ser21 in GSK3α…”
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Absence of platelet phenotype in mice lacking the motor protein myosin Va by Harper, Matthew T, van den Bosch, Marion T J, Hers, Ingeborg, Poole, Alastair W

“…The motor protein myosin Va plays an important role in the trafficking of intracellular vesicles. Mutation of the Myo5a gene causes Griscelli syndrome type 1…”
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