Search Results - "van den Berk, Linda"
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Fluorescent tagging of endogenous Heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages
Published in Archives of toxicology (01-10-2021)“…Tagging of endogenous stress response genes can provide valuable in vitro models for chemical safety assessment. Here, we present the generation and…”
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A novel human cell culture model to study visceral smooth muscle phenotypic modulation in health and disease
Published in American Journal of Physiology: Cell Physiology (01-10-2018)“…Adaptation of the smooth muscle cell (SMC) phenotype is essential for homeostasis and is often involved in pathologies of visceral organs (e.g., uterus,…”
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Journal Article -
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Identifying multiscale translational safety biomarkers using a network-based systems approach
Published in iScience (17-03-2023)“…Animal testing is the current standard for drug and chemicals safety assessment, but hazards translation to human is uncertain. Human in vitro models can…”
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Squaramide‐Based Supramolecular Materials Drive HepG2 Spheroid Differentiation
Published in Advanced healthcare materials (01-06-2021)“…A major challenge in the use of HepG2 cell culture models for drug toxicity screening is their lack of maturity in 2D culture. 3D culture in Matrigel promotes…”
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