Search Results - "van den Berg, B. J."

Structural basis of selective cannabinoid CB2 receptor activation by Li, Xiaoting, Chang, Hao, Bouma, Jara, de Paus, Laura V., Mukhopadhyay, Partha, Paloczi, Janos, Mustafa, Mohammed, van der Horst, Cas, Kumar, Sanjay Sunil, Wu, Lijie, Yu, Yanan, van den Berg, Richard J. B. H. N., Janssen, Antonius P. A., Lichtman, Aron, Liu, Zhi-Jie, Pacher, Pal, van der Stelt, Mario, Heitman, Laura H., Hua, Tian

“…Cannabinoid CB 2 receptor (CB 2 R) agonists are investigated as therapeutic agents in the clinic. However, their molecular mode-of-action is not fully…”
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Glycosphingolipids-Nature, Function, and Pharmacological Modulation by Wennekes, Tom, van den Berg, Richard J. B. H. N., Boot, Rolf G., van der Marel, Gijsbert A., Overkleeft, Herman S., Aerts, Johannes M. F. G.

“…The discovery of the glycosphingolipids is generally attributed to Johan L. W. Thudichum, who in 1884 published on the chemical composition of the brain. In…”
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Design and Synthesis of Quenched Activity‐based Probes for Diacylglycerol Lipase and α,β‐Hydrolase Domain Containing Protein 6 by van Rooden, E. J., Kohsiek, M., Kreekel, R., van Esbroeck, A. C. M., van den Nieuwendijk, A. M. C. H., Janssen, A. P. A., van den Berg, R. J. B. H. N., Overkleeft, H. S., van der Stelt, M.

“…Diacylglycerol lipases (DAGL) are responsible for the biosynthesis of the endocannabinoid 2‐arachidonoylglycerol. The fluorescent activity‐based probes DH379…”
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Development of Adamantan-1-yl-methoxy-Functionalized 1-Deoxynojirimycin Derivatives as Selective Inhibitors of Glucosylceramide Metabolism in Man by Wennekes, Tom, van den Berg, Richard J. B. H. N, Donker, Wilma, van der Marel, Gijsbert A, Strijland, Anneke, Aerts, Johannes M. F. G, Overkleeft, Herman S

“…In this article, we present a straightforward synthesis of adamantan-1-yl-methoxy-functionalized 1-deoxynojirimycin derivatives. The used synthetic routes are…”
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Disruptive selection as a driver of evolutionary branching and caste evolution in social insects by Planqué, R., Powell, S., Franks, N. R., Berg, J. B.

“…Theory suggests that evolutionary branching via disruptive selection may be a relatively common and powerful force driving phenotypic divergence. Here, we…”
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The Development of an Aza-C-Glycoside Library Based on a Tandem Staudinger/Aza-Wittig/Ugi Three-Component Reaction by Wennekes, Tom, Bonger, Kimberly M., Vogel, Katrin, van den Berg, Richard J. B. H. N., Strijland, Anneke, Donker-Koopman, Wilma E., Aerts, Johannes M. F. G., van der Marel, Gijsbert A., Overkleeft, Herman S.

“…We report the tandem Staudinger/aza‐Wittig/Ugi three‐component reaction mediated synthesis of a 64‐member compound library of aza‐C‐glycosides. The library is…”
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Synthesis of l-altro-1-Deoxynojirimycin, d-allo-1-Deoxynojirimycin, and d-galacto-1-Deoxynojirimycin from a Single Chiral Cyanohydrin by van den Nieuwendijk, Adrianus M. C. H, Ruben, Mark, Engelsma, Sander E, Risseeuw, Martijn D. P, van den Berg, Richard J. B. H. N, Boot, Rolf G, Aerts, Johannes M, Brussee, Johannes, van der Marel, Gijs A, Overkleeft, Herman S

“…The chemoenzymatic synthesis of three 1-deoxynojirimycin-type iminosugars is reported. Key steps in the synthetic scheme include a Dibal…”
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Synthesis and Evaluation of Hybrid Structures Composed of Two Glucosylceramide Synthase Inhibitors by van den Berg, Richard J. B. H. N., van Rijssel, Erwin R., Ferraz, Maria Joao, Houben, Judith, Strijland, Anneke, Donker-Koopman, Wilma E., Wennekes, Tom, Bonger, Kimberly M., Ghisaidoobe, Amar B. T., Hoogendoorn, Sascha, van der Marel, Gijsbert A., Codée, Jeroen D. C., Overkleeft, Herman S., Aerts, Johannes M. F. G.

“…Glucosylceramide metabolism and the enzymes involved have attracted significant interest in medicinal chemistry, because aberrations in the levels of…”
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An Efficient Synthesis of the Natural Tetrahydrofuran Pachastrissamine Starting from d-ribo-Phytosphingosine by van den Berg, Richard J. B. H. N, Boltje, Thomas J, Verhagen, Carlo P, Litjens, Remy E. J. N, van der Marel, Gijsbert A, Overkleeft, Herman S

“…The natural product pachastrissamine, an anhydrophytosphingosine derivative isolated from various sponges and endowed with cytotoxic activity against several…”
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Discovery of a Photoaffinity Probe that Captures the Active Conformation of the Cannabinoid CB2 Receptor by De Paus, Laura V., An, Yu, Janssen, Antonius P. A., Berg, Richard J. B. H. N., Heitman, Laura H., Stelt, Mario

“…The cannabinoid receptor type 2 (CB2R) is a G protein‐coupled receptor with therapeutic potential for the treatment of inflammatory disorders. Fluorescent…”
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Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding by Deng, Hui, Kooijman, Sander, van den Nieuwendijk, Adrianus M. C. H, Ogasawara, Daisuke, van der Wel, Tom, van Dalen, Floris, Baggelaar, Marc P, Janssen, Freek J, van den Berg, Richard J. B. H. N, den Dulk, Hans, Cravatt, Benjamin F, Overkleeft, Herman S, Rensen, Patrick C. N, van der Stelt, Mario

“…Triazole ureas constitute a versatile class of irreversible inhibitors that target serine hydrolases in both cells and animal models. We have previously…”
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Identification and Development of Biphenyl Substituted Iminosugars as Improved Dual Glucosylceramide Synthase/Neutral Glucosylceramidase Inhibitors by Ghisaidoobe, Amar T, van den Berg, Richard J. B. H. N, Butt, Saleem S, Strijland, Anneke, Donker-Koopman, Wilma E, Scheij, Saskia, van den Nieuwendijk, Adrianus M. C. H, Koomen, Gerrit-Jan, van Loevezijn, Arnold, Leemhuis, Mark, Wennekes, Tom, van der Stelt, Mario, van der Marel, Gijsbert A, van Boeckel, Constant A. A, Aerts, Johannes M. F. G, Overkleeft, Herman S

“…This work details the evaluation of a number of N-alkylated deoxynojirimycin derivatives on their merits as dual glucosylceramide synthase/neutral…”
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Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria by Bakker, Alexander T., Kotsogianni, Ioli, Avalos, Mariana, Punt, Jeroen M., Liu, Bing, Piermarini, Diana, Gagestein, Berend, Slingerland, Cornelis J., Zhang, Le, Willemse, Joost J., Ghimire, Leela B., van den Berg, Richard J. H. B. N., Janssen, Antonius P. A., Ottenhoff, Tom H. M., van Boeckel, Constant A. A., van Wezel, Gilles P., Ghilarov, Dmitry, Martin, Nathaniel I., van der Stelt, Mario

“…Bacteria have evolved resistance to nearly all known antibacterials, emphasizing the need to identify antibiotics that operate via novel mechanisms. Here we…”
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Synthesis of 6‑Hydroxysphingosine and α‑Hydroxy Ceramide Using a Cross-Metathesis Strategy by Wisse, Patrick, de Geus, Mark A. R, Cross, Gen, van den Nieuwendijk, Adrianus M. C. H, van Rooden, Eva J, van den Berg, Richard J. B. H. N, Aerts, Johannes M. F. G, van der Marel, Gijsbert A, Codée, Jeroen D. C, Overkleeft, Herman S

“…In this paper, a new synthetic route toward 6-hydroxysphingosine and α-hydroxy ceramide is described. The synthesis employs a cross-metathesis to unite a…”
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Human papillomavirus antibody and risk of prostate cancer by Hisada, M, Rabkin, C S, Strickler, H D, Wright, W E, Christianson, R E, van den Berg, B J

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A chemical genetic screen reveals that iminosugar inhibitors of plant glucosylceramide synthase inhibit root growth in Arabidopsis and cereals by Rugen, Michael D., Vernet, Mathieu M. J. L., Hantouti, Laila, Soenens, Amalia, Andriotis, Vasilios M. E., Rejzek, Martin, Brett, Paul, van den Berg, Richard J. B. H. N., Aerts, Johannes M. F. G., Overkleeft, Hermen S., Field, Robert A.

“…Iminosugars are carbohydrate mimics that are useful as molecular probes to dissect metabolism in plants. To analyse the effects of iminosugar derivatives on…”
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Epi-Cyclophellitol Cyclosulfate, a Mechanism-Based Endoplasmic Reticulum α‑Glucosidase II Inhibitor, Blocks Replication of SARS-CoV‑2 and Other Coronaviruses by Thaler, Melissa, Ofman, Tim P., Kok, Ken, Heming, Jurriaan J. A., Moran, Elisha, Pickles, Isabelle, Leijs, Anouk A., van den Nieuwendijk, Adrianus M. C. H., van den Berg, Richard J. B. H. N., Ruijgrok, Gijs, Armstrong, Zachary, Salgado-Benvindo, Clarisse, Ninaber, Dennis K., Snijder, Eric J., van Boeckel, Constant A. A., Artola, Marta, Davies, Gideon J., Overkleeft, Herman S., van Hemert, Martijn J.

“…The combined inhibition of endoplasmic reticulum (ER) α-glucosidases I and II has been shown to inhibit replication of a broad range of viruses that rely on ER…”
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A randomised controlled trial of aerobic exercise after transient ischaemic attack or minor stroke to prevent cognitive decline: the MoveIT study protocol by Boss, H M, Van Schaik, S M, Deijle, I A, de Melker, E C, van den Berg, B T J, Scherder, E J A, Bosboom, W M J, Weinstein, H C, Van den Berg-Vos, R M

“…Introduction Patients with transient ischaemic attack (TIA) or stroke are at risk for cognitive impairment and dementia. Currently, there is no known effective…”
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Second order Lagrangian Twist systems: simple closed characteristics by Van Den Berg, J. B., Vandervorst, R. C.

“…We consider a special class of Lagrangians that play a fundamental role in the theory of second order Lagrangian systems: Twist systems. This subclass of…”
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ortho-Carborane-Modified N-Substituted Deoxynojirimycins by Hoogendoorn, Sascha, Mock, Elliot D., Strijland, Anneke, Donker-Koopman, Wilma E., van den Elst, Hans, van den Berg, Richard J. B. H. N., Aerts, Johannes M. F. G., van der Marel, Gijsbert A., Overkleeft, Herman S.

“…N‐alkyl‐deoxynojirimycins (DNMs) are an important class of glycoprocessing enzyme inhibitors. Our work on DNMs focuses on identifying potent and selective…”
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