Search Results - "van den Berg, Aafke"
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Chromosome organization by one-sided and two-sided loop extrusion
Published in eLife (06-04-2020)“…SMC complexes, such as condensin or cohesin, organize chromatin throughout the cell cycle by a process known as loop extrusion. SMC complexes reel in DNA,…”
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2
Crowding-induced transcriptional bursts dictate polymerase and nucleosome density profiles along genes
Published in Nucleic acids research (27-07-2017)“…During eukaryotic transcription, RNA polymerase (RNAP) translocates along DNA molecules covered with nucleosomes and other DNA binding proteins. Though the…”
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RNA polymerases as moving barriers to condensin loop extrusion
Published in Proceedings of the National Academy of Sciences - PNAS (08-10-2019)“…To separate replicated sister chromatids during mitosis, eukaryotes and prokaryotes have structural maintenance of chromosome (SMC) condensin complexes that…”
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4
Transcription shapes 3D chromatin organization by interacting with loop extrusion
Published in Proceedings of the National Academy of Sciences - PNAS (14-03-2023)“…Cohesin folds mammalian interphase chromosomes by extruding the chromatin fiber into numerous loops. "Loop extrusion" can be impeded by chromatin-bound…”
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Probing the mechanism of nick searching by LIG1 at the single-molecule level
Published in Nucleic acids research (15-10-2024)“…DNA ligase 1 (LIG1) joins Okazaki fragments during the nuclear replication and completes DNA repair pathways by joining 3'-OH and 5'-PO4 ends of nick at the…”
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Resolving the subtle details of human DNA alkyltransferase lesion search and repair mechanism by single-molecule studies
Published in Proceedings of the National Academy of Sciences - PNAS (15-03-2022)“…SignificanceWe directly visualize DNA translocation and lesion recognition by the O -alkylguanine DNA alkyltransferase (AGT). Our data show bidirectional…”
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7
Slow unloading leads to DNA-bound β2-sliding clamp accumulation in live Escherichia coli cells
Published in Nature communications (18-12-2014)“…The ubiquitous sliding clamp facilitates processivity of the replicative polymerase and acts as a platform to recruit proteins involved in replication,…”
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8
The 4D nucleome project
Published in Nature (London) (14-09-2017)“…The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal…”
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9
RNAP as a Moving Barrier to Loop Extrusion
Published in Biophysical journal (01-02-2019)Get full text
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10
Crowding on DNA as a Source of Bursts in mRNA Production
Published in Biophysical journal (27-01-2015)Get full text
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11
Single pairs of time-bin-entangled photons
Published in Physical review. A, Atomic, molecular, and optical physics (02-09-2015)Get full text
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12
Single pairs of time-bin entangled photons
Published 07-07-2015“…Phys. Rev. A 92, 033802 (2015) Time-bin entangled photons are ideal for long-distance quantum communication via optical fibers. Here we present a source where,…”
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13
Slow unloading leads to DNA-bound [beta]2-sliding clamp accumulation in live Escherichia coli cells
Published in Nature communications (01-12-2014)“…The ubiquitous sliding clamp facilitates processivity of the replicative polymerase and acts as a platform to recruit proteins involved in replication,…”
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