Search Results - "van de Wier, Bregje"

The potential of flavonoids in the treatment of non-alcoholic fatty liver disease by Van De Wier, Bregje, Koek, Ger H., Bast, Aalt, Haenen, Guido R. M. M.

“…The contemporary pathophysiological model of non-alcoholic fatty liver disease (NAFLD) comprises multiple parallel pathways with a dynamic cross talk that…”
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Elevated citrate levels in non-alcoholic fatty liver disease: The potential of citrate to promote radical production by van de Wier, Bregje, Balk, Jiska M., Haenen, Guido R.M.M., Giamouridis, Dimosthenis, Bakker, Jaap A., Bast, Bertine C., den Hartog, Gertjan J.M., Koek, Ger H., Bast, Aalt

“…•Citrate levels are elevated in patients with non-alcoholic fatty liver disease.•Intracellular citrate levels are elevated upon exposure to an excess of fatty…”
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The flavonoid monoHER promotes the adaption to oxidative stress during the onset of NAFLD by Lemmens, Kristien J.A., van de Wier, Bregje, Koek, Ger H., Köhler, Eleonore, Drittij, Marie-José, van der Vijgh, Wim J.F., Bast, Aalt, Haenen, Guido R.M.M.

“…•MonoHER tended to further increase the adaptive response and the redox status in the Ldlr−/− group.•Within the Ldlr−/− animal, monoHER linked an improved…”
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The flavonoid 7-mono-O-(β-hydroxyethyl)-rutoside is able to protect endothelial cells by a direct antioxidant effect by Lemmens, Kristien J.A., van de Wier, Bregje, Vaes, Nathalie, Ghosh, Mitrajit, van Zandvoort, Marc A.M.J., van der Vijgh, Wim J.F., Bast, Aalt, Haenen, Guido R.M.M.

“…•We studied the direct scavenging activity of the flavonoid 7-mono-O-(β-hydroxyethyl)-rutoside.•MonoHER instantaneously protects against oxidative stress in…”
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