Search Results - "van de Westerlo, Els M.A."

Antibody GD3G7 Selected against Embryonic Glycosaminoglycans Defines Chondroitin Sulfate-E Domains Highly Up-Regulated in Ovarian Cancer and Involved in Vascular Endothelial Growth Factor Binding by ten Dam, Gerdy B, van de Westerlo, Els M.A, Purushothaman, Anurag, Stan, Radu V, Bulten, Johan, Sweep, Fred C.G.J, Massuger, Leon F, Sugahara, Kazuyuki, van Kuppevelt, Toin H

“…Chondroitin sulfate (CS) is abundantly present in the tumor stroma, and tumor-specific CS modifications might be potential targets to influence tumor…”
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Heparan Sulfate Phage Display Antibodies Identify Distinct Epitopes with Complex Binding Characteristics: INSIGHTS INTO PROTEIN BINDING SPECIFICITIES by Thompson, Sophie M, Fernig, David G, Jesudason, Edwin C, Losty, Paul D, van de Westerlo, Els M.A, van Kuppevelt, Toin H, Turnbull, Jeremy E

“…Heparan sulfate (HS) binds and modulates the transport and activity of a large repertoire of regulatory proteins. The HS phage display antibodies are powerful…”
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3-O-Sulfated Oligosaccharide Structures Are Recognized by Anti-heparan Sulfate Antibody HS4C3 by Dam, Gerdy B. ten, Kurup, Sindhulakshmi, van de Westerlo, Els M.A., Versteeg, Elly M.M., Lindahl, Ulf, Spillmann, Dorothe, van Kuppevelt, Toin H.

“…Antibodies against heparan sulfate (HS) are useful tools to study the structural diversity of HS. They demonstrate the large sequential variation within HS and…”
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Dermatan sulfate domains defined by the novel antibody GD3A12, in normal tissues and ovarian adenocarcinomas by ten Dam, Gerdy B, Yamada, Shuhei, Kobayashi, Fumi, Purushothaman, Anurag, van de Westerlo, Els M.A, Bulten, Johan, Malmström, Anders, Sugahara, Kazuyuki, Massuger, Leon F, van Kuppevelt, Toin H

“…Dermatan sulfate (DS) expression in normal tissue and ovarian cancer was investigated using the novel, phage display-derived antibody GD3A12 that was selected…”
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Stress‐dependent macromolecular crowding in the mitochondrial matrix by Bulthuis, Elianne P, Dieteren, Cindy E J, Bergmans, Jesper, Berkhout, Job, Wagenaars, Jori A, van de Westerlo, Els M A, Podhumljak, Emina, Hink, Mark A, Hesp, Laura F B, Rosa, Hannah S, Malik, Afshan N, Lindert, Mariska Kea‐te, Willems, Peter H G M, Gardeniers, Han J G E, den Otter, Wouter K, Adjobo‐Hermans, Merel J W, Koopman, Werner J H

“…Macromolecules of various sizes induce crowding of the cellular environment. This crowding impacts on biochemical reactions by increasing solvent viscosity,…”
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Construction and evaluation of an antibody phage display library targeting heparan sulfate by Damen, Lars A.A., van de Westerlo, Els M.A., Versteeg, Elly M.M., van Wessel, Thierry, Daamen, Willeke F., van Kuppevelt, Toin H.

“…Heparan sulfate (HS) is a linear polysaccharide with high structural diversity. Different HS epitopes have been detected and localized using single chain…”
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The Polybasic Insertion in Autotaxin α Confers Specific Binding to Heparin and Cell Surface Heparan Sulfate Proteoglycans by Houben, Anna J.S., van Wijk, Xander M.R., van Meeteren, Laurens A., van Zeijl, Leonie, van de Westerlo, Els M.A., Hausmann, Jens, Fish, Alexander, Perrakis, Anastassis, van Kuppevelt, Toin H., Moolenaar, Wouter H.

“…Autotaxin (ATX) is a secreted lysophospholipase D that generates the lipid mediator lysophosphatidic acid (LPA), playing a key role in diverse physiological…”
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Sequencing of glycosaminoglycans with potential to interrogate sequence-specific interactions by van Kuppevelt, Toin H., Oosterhof, Arie, Versteeg, Elly M. M., Podhumljak, Emina, van de Westerlo, Els M. A., Daamen, Willeke F.

“…Technologies to sequence nucleic acids/proteins are widely available, but straightforward methodologies to sequence complex polysaccharides are lacking. We…”
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'Immunosequencing' of heparan sulfate from human cell lines and rat kidney: the (GlcNS6S-IdoA2S)₃ motif, recognized by antibody NS4F5, is located towards the non-reducing end by van Wijk, Xander M R, Oosterhof, Arie, Versteeg, Elly M M, van de Westerlo, Els M A, van Kuppevelt, Toin H

“…HS (heparan sulfate) is a long linear polysaccharide, variably modified by epimerization and sulfation reactions, and is organized into different domains…”
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Use of flow cytometry for characterization and fractionation of cell populations based on their expression of heparan sulfate epitopes by Holley, Rebecca J, Smith, Raymond A, van de Westerlo, Els M A, Pickford, Claire E, Merry, C L R, van Kuppevelt, Toin H

“…The ability to characterize alterations in heparan sulfate (HS) structure during development or as a result of loss or mutation of one or more components of…”
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Human Single-Chain Antibodies Reactive with Native Chondroitin Sulfate Detect Chondroitin Sulfate Alterations in Melanoma and Psoriasis by Smetsers, Toon F.C.M., van de Westerlo, Els M.A., ten Dam, Gerdy B., Overes, Ingrid M., Schalkwijk, Joost, van Muijen, Goos N.P., van Kuppevelt, Toin H.

“…Chondroitin sulfate (CS) belongs to the group of glycosaminoglycans (GAGs), which are linear polysaccharides, located in the extracellular matrix and on the…”
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Heparan Sulfate Phage Display Antibodies Identify Distinct Epitopes with Complex Binding Characteristics by Thompson, Sophie M., Fernig, David G., Jesudason, Edwin C., Losty, Paul D., van de Westerlo, Els M.A., van Kuppevelt, Toin H., Turnbull, Jeremy E.

“…Heparan sulfate (HS) binds and modulates the transport and activity of a large repertoire of regulatory proteins. The HS phage display antibodies are powerful…”
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Heterogeneity of Heparan Sulfates in Human Lung by Smits, Nicole C, Robbesom, Antoine A, Versteeg, Elly M. M, van de Westerlo, Els M. A, Dekhuijzen, P. N. Richard, van Kuppevelt, Toin H

“…Heparan sulfates (HS), a class of glycosaminoglycans, are long linear complex polysaccharides covalently attached to a protein core. The HS molecules are made…”
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Localization and characterization of melanoma-associated glycosaminoglycans: Differential expression of chondroitin and heparan sulfate epitopes in melanoma by SMETSERS, Toon F. C. M, VAN DE WESTERLO, Els M. A, TEN DAM, Gerdy B, CLARIJS, Ruud, VERSTEEG, Elly M. M, VAN GELOOF, Winnie L, VEERKAMP, Jacques H, VAN MUIJEN, Goos N. P, VAN KUPPEVELT, Toin H

“…Glycosaminoglycans (GAGs) are anionic polysaccharides present on cells and in the extracellular matrix (ECM). They likely play a role in tumor formation…”
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Detection of 2-O-Sulfated Iduronate and N-Acetylglucosamine Units in Heparan Sulfate by an Antibody Selected against Acharan Sulfate (IdoA2S-GlcNAc) by ten Dam, Gerdy B., van de Westerlo, Els M.A., Smetsers, Toon F.C.M., Willemse, Marieke, van Muijen, Goos N.P., Merry, Catherine L.R., Gallagher, John T., Kim, Yeong S., van Kuppevelt, Toin H.

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Human single chain antibodies against heparin: selection, characterization, and effect on coagulation by van de Westerlo, Els M.A., Smetsers, Toon F.C.M., Dennissen, Michel A.B.A., Linhardt, Robert J., Veerkamp, Jacques H., van Muijen, Goos N.P., van Kuppevelt, Toin H.

“…Heparin, located in mast cells and basophilic granulocytes, is widely used as an anticoagulant. It belongs to a class of linear polysaccharides called…”
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Detection of 2-O-Sulfated Iduronate and N-Acetylglucosamine Units in Heparan Sulfate by an Antibody Selected against Acharan Sulfate (IdoA2S-GlcNAc)n by ten Dam, Gerdy B., van de Westerlo, Els M.A., Smetsers, Toon F.C.M., Willemse, Marieke, van Muijen, Goos N.P., Merry, Catherine L.R., Gallagher, John T., Kim, Yeong S., van Kuppevelt, Toin H.

“…The snail glycosaminoglycan acharan sulfate (AS) is structurally related to heparan sulfates (HS) and has a repeating disaccharide structure of…”
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Rat pancreatic nucleoside diphosphate kinase, a novel regulator of cholecystokinin receptor affinity. Cloning and expression by Blevins, Jr, G T, van de Westerlo, E M, Blevins, P M, Williams, J A

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