Search Results - "van de Weijer, Tineke"

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans by Remie, Carlijn ME, Roumans, Kay HM, Moonen, Michiel PB, Connell, Niels J, Havekes, Bas, Mevenkamp, Julian, Lindeboom, Lucas, de Wit, Vera HW, van de Weijer, Tineke, Aarts, Suzanne ABM, Lutgens, Esther, Schomakers, Bauke V, Elfrink, Hyung L, Zapata-Pérez, Rubén, Houtkooper, Riekelt H, Auwerx, Johan, Hoeks, Joris, Schrauwen-Hinderling, Vera B, Phielix, Esther, Schrauwen, Patrick

“…Nicotinamide riboside (NR) is an NAD+ precursor that boosts cellular NAD+ concentrations. Preclinical studies have shown profound metabolic health effects…”
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Lipotoxicity in type 2 diabetic cardiomyopathy by van de Weijer, Tineke, Schrauwen-Hinderling, Vera B., Schrauwen, Patrick

“…As obesity and type 2 diabetes are becoming an epidemic in westernized countries, the incidence and prevalence of obesity- and diabetes-related co-morbidities…”
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Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans by Timmers, Silvie, Konings, Ellen, Bilet, Lena, Houtkooper, Riekelt H., van de Weijer, Tineke, Goossens, Gijs H., Hoeks, Joris, van der Krieken, Sophie, Ryu, Dongryeol, Kersten, Sander, Moonen-Kornips, Esther, Hesselink, Matthijs K.C., Kunz, Iris, Schrauwen-Hinderling, Vera B., Blaak, Ellen E., Auwerx, Johan, Schrauwen, Patrick

“…Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal…”
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A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes by Vanweert, Froukje, Neinast, Michael, Tapia, Edmundo Erazo, van de Weijer, Tineke, Hoeks, Joris, Schrauwen-Hinderling, Vera B., Blair, Megan C., Bornstein, Marc R., Hesselink, Matthijs K. C., Schrauwen, Patrick, Arany, Zoltan, Phielix, Esther

“…Elevations in plasma branched-chain amino acid (BCAA) levels associate with insulin resistance and type 2 diabetes (T2D). Pre-clinical models suggest that…”
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Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity by MEEX, Ruth C. R, SCHRAUWEN-HINDERLING, Vera B, MOONEN-KORNIPS, Esther, SCHAART, Gert, MENSINK, Marco, PHIELIX, Esther, VAN DE WEIJER, Tineke, SELS, Jean-Pierre, SCHRAUWEN, Patrick, HESSELINK, Matthijs K. C

“…Mitochondrial dysfunction and fat accumulation in skeletal muscle (increased intramyocellular lipid [IMCL]) have been linked to development of type 2 diabetes…”
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Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans by van de Weijer, Tineke, Phielix, Esther, Bilet, Lena, Williams, Evan G, Ropelle, Eduardo R, Bierwagen, Alessandra, Livingstone, Roshan, Nowotny, Peter, Sparks, Lauren M, Paglialunga, Sabina, Szendroedi, Julia, Havekes, Bas, Moullan, Norman, Pirinen, Eija, Hwang, Jong-Hee, Schrauwen-Hinderling, Vera B, Hesselink, Matthijs K C, Auwerx, Johan, Roden, Michael, Schrauwen, Patrick

“…Recent preclinical studies showed the potential of nicotinamide adenine dinucleotide (NAD(+)) precursors to increase oxidative phosphorylation and improve…”
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One-leg inactivity induces a reduction in mitochondrial oxidative capacity, intramyocellular lipid accumulation and reduced insulin signalling upon lipid infusion: a human study with unilateral limb suspension by Bilet, Lena, Phielix, Esther, van de Weijer, Tineke, Gemmink, Anne, Bosma, Madeleen, Moonen-Kornips, Esther, Jorgensen, Johanna A., Schaart, Gert, Zhang, Dongyan, Meijer, Kenneth, Hopman, Maria, Hesselink, Matthijs K. C., Ouwens, D. Margriet, Shulman, Gerald I., Schrauwen-Hinderling, Vera B., Schrauwen, Patrick

“…Aims/hypothesis Physical inactivity, low mitochondrial function, increased intramyocellular lipid (IMCL) deposition and reduced insulin sensitivity are common…”
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Relationships between mitochondrial function and metabolic flexibility in type 2 diabetes mellitus by van de Weijer, Tineke, Sparks, Lauren Marie, Phielix, Esther, Meex, Ruth Carla, van Herpen, Noud Antonius, Hesselink, Matthijs Karel C, Schrauwen, Patrick, Schrauwen-Hinderling, Vera Bettina

“…Mitochondrial dysfunction, lipid accumulation, insulin resistance and metabolic inflexibility have been implicated in the etiology of type 2 diabetes (T2D),…”
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Cardiac metabolic imaging: current imaging modalities and future perspectives by van de Weijer, Tineke, Paiman, Elisabeth Helena Maria, Lamb, Hildo J

“…In this review, current imaging techniques and their future perspectives in the field of cardiac metabolic imaging in humans are discussed. This includes a…”
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PCr/ATP ratios and mitochondrial function in the heart. A comparative study in humans by de Wit-Verheggen, Vera H. W., Schrauwen-Hinderling, Vera B., Brouwers, Kim, Jörgensen, Johanna A., Schaart, Gert, Gemmink, Anne, Nascimento, Emmani B. M., Hesselink, Matthijs K. C., Wildberger, Joachim E., Segers, Patrique, Montaigne, David, Staels, Bart, Schrauwen, Patrick, Lindeboom, Lucas, Hoeks, Joris, van de Weijer, Tineke

“…Cardiac energy status, measured as phosphocreatine (PCr)/adenosine triphosphate (ATP) ratio with 31P-Magnetic Resonance Spectroscopy (31P-MRS) in vivo, is a…”
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Correction to: Pericardial fat and its influence on cardiac diastolic function by de Wit-Verheggen, Vera H W, Altintas, Sibel, Spee, Romy J M, Mihl, Casper, van Kuijk, Sander M J, Wildberger, Joachim E, Schrauwen-Hinderling, Vera B, Kietselaer, Bas L J H, van de Weijer, Tineke

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Pericardial fat and its influence on cardiac diastolic function by de Wit-Verheggen, Vera H W, Altintas, Sibel, Spee, Romy J M, Mihl, Casper, van Kuijk, Sander M J, Wildberger, Joachim E, Schrauwen-Hinderling, Vera B, Kietselaer, Bas L J H, van de Weijer, Tineke

“…Pericardial fat (PF) has been suggested to directly act on cardiomyocytes, leading to diastolic dysfunction. The aim of this study was to investigate whether a…”
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Limited Additional Value of a Chest CT in Whole-Body Staging with PET-MRI: A Retrospective Cohort Study by Weijer, Tineke van de, van der Meer, Wilhelmina L, Moonen, Rik P M, van Nijnatten, Thiemo J A, Gietema, Hester A, Mitea, Cristina, van der Pol, Jochem A J, Wildberger, Joachim E, Mottaghy, Felix M

“…Hybrid PET-MRI systems are being used more frequently. One of the drawbacks of PET-MRI imaging is its inferiority in detecting lung nodules, so it is often…”
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Changes in Cardiac Metabolism in Prediabetes by de Wit-Verheggen, Vera H W, van de Weijer, Tineke

“…In type 2 diabetes mellitus (T2DM), there is an increased prevalence of cardiovascular disease (CVD), even when corrected for atherosclerosis and other CVD…”
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The Use of 18F-FET-PET-MRI in Neuro-Oncology: The Best of Both Worlds—A Narrative Review by van de Weijer, Tineke, Broen, Martijn P. G., Moonen, Rik P. M., Hoeben, Ann, Anten, Monique, Hovinga, Koos, Compter, Inge, van der Pol, Jochem A. J., Mitea, Cristina, Lodewick, Toine M., Jacquerie, Arnaud, Mottaghy, Felix M., Wildberger, Joachim E., Postma, Alida A.

“…Gliomas are the most frequent primary tumors of the brain. They can be divided into grade II-IV astrocytomas and grade II-III oligodendrogliomas, based on…”
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Cardiac lipid content is unresponsive to a physical activity training intervention in type 2 diabetic patients, despite improved ejection fraction by Schrauwen-Hinderling, Vera B, Meex, Ruth C R, Hesselink, Matthijs K C, van de Weijer, Tineke, Leiner, Tim, Schär, Michael, Lamb, Hildo J, Wildberger, Joachim E, Glatz, Jan F C, Schrauwen, Patrick, Kooi, M Eline

“…Increased cardiac lipid content has been associated with diabetic cardiomyopathy. We recently showed that cardiac lipid content is reduced after 12 weeks of…”
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Advances and challenges in measuring hepatic glucose uptake with FDG PET: implications for diabetes research by Basset-Sagarminaga, Jeremy, van de Weijer, Tineke, Iozzo, Patricia, Schrauwen, Patrick, Schrauwen-Hinderling, Vera

“…The liver plays a crucial role in the control of glucose homeostasis and is therefore of great interest in the investigation of the development of type 2…”
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Correction to: Advances and challenges in measuring hepatic glucose uptake with FDG PET: implications for diabetes research by Basset‑Sagarminaga, Jeremy, van de Weijer, Tineke, Iozzo, Patricia, Schrauwen, Patrick, Schrauwen‑Hinderling, Vera

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Application of Magnetic Resonance Spectroscopy in metabolic research by van de Weijer, Tineke, Schrauwen-Hinderling, Vera B.

“…The etiology of metabolic disease in humans is far from understood, and even though potential pathways are identified in animal models and cell studies, it is…”
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Resveratrol as Add-on Therapy in Subjects With Well-Controlled Type 2 Diabetes: A Randomized Controlled Trial by Timmers, Silvie, de Ligt, Marlies, Phielix, Esther, van de Weijer, Tineke, Hansen, Jan, Moonen-Kornips, Esther, Schaart, Gert, Kunz, Iris, Hesselink, Matthijs K C, Schrauwen-Hinderling, Vera B, Schrauwen, Patrick

“…To determine whether resveratrol supplementation can improve insulin sensitivity and promote overall metabolic health on top of standard diabetes care…”
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