Search Results - "van de Veerdonk, Frank L"

Rewiring monocyte glucose metabolism via C-type lectin signaling protects against disseminated candidiasis by Domínguez-Andrés, Jorge, Arts, Rob J W, Ter Horst, Rob, Gresnigt, Mark S, Smeekens, Sanne P, Ratter, Jacqueline M, Lachmandas, Ekta, Boutens, Lily, van de Veerdonk, Frank L, Joosten, Leo A B, Notebaart, Richard A, Ardavín, Carlos, Netea, Mihai G

“…Monocytes are innate immune cells that play a pivotal role in antifungal immunity, but little is known regarding the cellular metabolic events that regulate…”
Get full text

Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome by van de Veerdonk, Frank L, Netea, Mihai G, van Deuren, Marcel, van der Meer, Jos Wm, de Mast, Quirijn, Brüggemann, Roger J, van der Hoeven, Hans

“…COVID-19 patients can present with pulmonary edema early in disease. We propose that this is due to a local vascular problem because of activation of…”
Get full text

Metabolic Induction of Trained Immunity through the Mevalonate Pathway by Bekkering, Siroon, Arts, Rob J.W., Novakovic, Boris, Kourtzelis, Ioannis, van der Heijden, Charlotte D.C.C., Li, Yang, Popa, Calin D., ter Horst, Rob, van Tuijl, Julia, Netea-Maier, Romana T., van de Veerdonk, Frank L., Chavakis, Triantafyllos, Joosten, Leo A.B., van der Meer, Jos W.M., Stunnenberg, Henk, Riksen, Niels P., Netea, Mihai G.

“…Innate immune cells can develop long-term memory after stimulation by microbial products during infections or vaccinations. Here, we report that metabolic…”
Get full text

COVID-19 Associated Pulmonary Aspergillosis (CAPA)—From immunology to treatment by Arastehfar, Amir, Carvalho, Agostinho, van de Veerdonk, Frank L., Jenks, Jeffrey D., Koehler, Philipp, Krause, Robert, Cornely, Oliver A., S. Perlin, David, Lass-Flörl, Cornelia, Hoenigl, Martin

“…Like severe influenza, coronavirus disease-19 (COVID-19) resulting in acute respiratory distress syndrome (ARDS) has emerged as an important disease that…”
Get full text

Multinational Observational Cohort Study of COVID-19-Associated Pulmonary Aspergillosis by Janssen, Nico A.F, Nyga, Remy, Vanderbeke, Lore, Jacobs, Cato, Ergun, Mehmet, Buil, Jochem B, van Dijk, Karin, Altenburg, Josje, Bouman, Catherine S.C, van der Spoel, Hans I, Rijnders, Bart J.A, Dunbar, Albert, Schouten, Jeroen A, Lagrou, Katrien, Bourgeois, Marc, Reynders, Marijke, van Regenmortel, Niels, Rutsaert, Lynn, Lormans, Piet, Feys, Simon, Debavaye, Yves, Tamion, Fabienne, Costa, Damien, Maizel, Julien, Dupont, Herve, Chouaki, Taieb, Nseir, Saad, Sendid, Boualem, Bruggemann, Roger J.M, van de Veerdonk, Frank L, Wauters, Joost, Verweij, Paul E

“…We performed an observational study to investigate intensive care unit incidence, risk factors, and outcomes of coronavirus disease–associated pulmonary…”
Get full text

Aspergillus Cell Wall Melanin Blocks LC3-Associated Phagocytosis to Promote Pathogenicity by Akoumianaki, Tonia, Kyrmizi, Irene, Valsecchi, Isabel, Gresnigt, Mark S., Samonis, George, Drakos, Elias, Boumpas, Dimitrios, Muszkieta, Laetitia, Prevost, Marie-Christine, Kontoyiannis, Dimitrios P., Chavakis, Triantafyllos, Netea, Mihai G., van de Veerdonk, Frank L., Brakhage, Axel A., El-Benna, Jamel, Beauvais, Anne, Latge, Jean-Paul, Chamilos, Georgios

“…Concealing pathogen-associated molecular patterns (PAMPs) is a principal strategy used by fungi to avoid immune recognition. Surface exposure of PAMPs during…”
Get full text

IL-37 inhibits inflammasome activation and disease severity in murine aspergillosis by Moretti, Silvia, Bozza, Silvia, Oikonomou, Vasilis, Renga, Giorgia, Casagrande, Andrea, Iannitti, Rossana G, Puccetti, Matteo, Garlanda, Cecilia, Kim, Soohyun, Li, Suzhao, van de Veerdonk, Frank L, Dinarello, Charles A, Romani, Luigina

“…Since IL-37 transgenic mice possesses broad anti-inflammatory properties, we assessed whether recombinant IL-37 affects inflammation in a murine model of…”
Get full text

Autophagy controls BCG-induced trained immunity and the response to intravesical BCG therapy for bladder cancer by Buffen, Kathrin, Oosting, Marije, Quintin, Jessica, Ng, Aylwin, Kleinnijenhuis, Johanneke, Kumar, Vinod, van de Vosse, Esther, Wijmenga, Cisca, van Crevel, Reinout, Oosterwijk, Egbert, Grotenhuis, Anne J, Vermeulen, Sita H, Kiemeney, Lambertus A, van de Veerdonk, Frank L, Chamilos, Georgios, Xavier, Ramnik J, van der Meer, Jos W M, Netea, Mihai G, Joosten, Leo A B

“…The anti-tuberculosis-vaccine Bacillus Calmette-Guérin (BCG) is the most widely used vaccine in the world. In addition to its effects against tuberculosis, BCG…”
Get full text

Anticytokine Autoantibodies in Infectious Diseases: A Practical Overview by Arts, Rob J W, Janssen, Nico A F, van de Veerdonk, Frank L

“…Anticytokine autoantibodies (ACAAs) are a fascinating group of antibodies that have gained more and more attention in the field of autoimmunity and secondary…”
Get full text

The Association of TSH and Thyroid Hormones With Lymphopenia in Bacterial Sepsis and COVID-19 by Grondman, Inge, de Nooijer, Aline H, Antonakos, Nikolaos, Janssen, Nico A F, Mouktaroudi, Maria, Leventogiannis, Konstantinos, Medici, Marco, Smit, Jan W A, van Herwaarden, Antonius E, Joosten, Leo A B, van de Veerdonk, Frank L, Pickkers, Peter, Kox, Matthijs, Jaeger, Martin, Netea, Mihai G, Giamarellos-Bourboulis, Evangelos J, Netea-Maier, Romana T

“…Abstract Context Lymphopenia is a key feature of immune dysfunction in patients with bacterial sepsis and coronavirus disease 2019 (COVID-19) and is associated…”
Get full text

Pathogenic NLRP3 Inflammasome Activity during Candida Infection Is Negatively Regulated by IL-22 via Activation of NLRC4 and IL-1Ra by Borghi, Monica, De Luca, Antonella, Puccetti, Matteo, Jaeger, Martin, Mencacci, Antonella, Oikonomou, Vasilis, Pariano, Marilena, Garlanda, Cecilia, Moretti, Silvia, Bartoli, Andrea, Sobel, Jack, van de Veerdonk, Frank L., Dinarello, Charles A., Netea, Mihai G., Romani, Luigina

“…Candida albicans is a well-tolerated resident of human mucosal tissues. This implies that host defense mechanisms cooperate to limit inflammation while…”
Get full text

A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonist by Gresnigt, Mark S, Bozza, Silvia, Becker, Katharina L, Joosten, Leo A B, Abdollahi-Roodsaz, Shahla, van der Berg, Wim B, Dinarello, Charles A, Netea, Mihai G, Fontaine, Thierry, De Luca, Antonella, Moretti, Silvia, Romani, Luigina, Latge, Jean-Paul, van de Veerdonk, Frank L

“…The galactosaminogalactan (GAG) is a cell wall component of Aspergillus fumigatus that has potent anti-inflammatory effects in mice. However, the mechanisms…”
Get full text

Opposing Effects of Interleukin-36γ and Interleukin-38 on Trained Immunity by Teufel, Lisa U, Netea, Mihai G, van de Veerdonk, Frank L, Dinarello, Charles A, Joosten, Leo A B, Arts, Rob J W

“…Trained immunity is the process of long-term functional reprogramming (a innate immune memory) of innate immune cells such as monocytes and macrophages after…”
Get full text

Genetic deficiency of NOD2 confers resistance to invasive aspergillosis by Gresnigt, Mark S., Cunha, Cristina, Jaeger, Martin, Gonçalves, Samuel M., Malireddi, R. K. Subbarao, Ammerdorffer, Anne, Lubbers, Rosalie, Oosting, Marije, Rasid, Orhan, Jouvion, Grégory, Fitting, Catherine, Jong, Dirk J. de, Lacerda, João, Campos, António, Melchers, Willem J. G., Lagrou, Katrien, Maertens, Johan, Kanneganti, Thirumala-Devi, Carvalho, Agostinho, Ibrahim-Granet, Oumaima, van de Veerdonk, Frank L.

“…© The Author(s) 2018. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing,…”
Get full text

Inflammasome-independent modulation of cytokine response by autophagy in human cells by Crişan, Tania O, Plantinga, Theo S, van de Veerdonk, Frank L, Farcaş, Marius F, Stoffels, Monique, Kullberg, Bart-Jan, van der Meer, Jos W M, Joosten, Leo A B, Netea, Mihai G

“…Autophagy is a cell housekeeping mechanism that has recently received attention in relation to its effects on the immune response. Genetic studies have…”
Get full text

The immunopathology of sepsis and potential therapeutic targets by van der Poll, Tom, van de Veerdonk, Frank L., Scicluna, Brendon P., Netea, Mihai G.

“…Key Points Sepsis is a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. The sepsis-associated host response is…”
Get full text

Increased sTREM-1 plasma concentrations are associated with poor clinical outcomes in patients with COVID-19 by de Nooijer, Aline H., Grondman, Inge, Lambden, Simon, Kooistra, Emma J., Janssen, Nico A.F., Kox, Matthijs, Pickkers, Peter, Joosten, Leo A.B., van de Veerdonk, Frank L., Derive, Marc, Gibot, Sebastien, Netea, Mihai G.

“…Abstract Patients with sepsis display increased concentrations of sTREM-1 (soluble Triggering Receptor Expressed on Myeloid cells 1), and a phase II clinical…”
Get full text

Anakinra Activates Superoxide Dismutase 2 to Mitigate Inflammasome Activity by Pariano, Marilena, Pieroni, Stefania, De Luca, Antonella, Iannitti, Rossana G., Borghi, Monica, Puccetti, Matteo, Giovagnoli, Stefano, Renga, Giorgia, D’Onofrio, Fiorella, Bellet, Marina M., Stincardini, Claudia, Della-Fazia, Maria Agnese, Servillo, Giuseppe, van de Veerdonk, Frank L., Costantini, Claudio, Romani, Luigina

“…Inflammasomes are powerful cytosolic sensors of environmental stressors and are critical for triggering interleukin-1 (IL-1)-mediated inflammatory responses…”
Get full text

Rare variants increase the risk of severe COVID-19 by van de Veerdonk, Frank L, Netea, Mihai G

“…Evidence is mounting that rare loss-of-function variants in the gene predispose men with no medical history to severe forms of COVID-19…”
Get full text

Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection by Netea, Mihai G., Giamarellos-Bourboulis, Evangelos J., Domínguez-Andrés, Jorge, Curtis, Nigel, van Crevel, Reinout, van de Veerdonk, Frank L., Bonten, Marc

“…SARS-CoV-2 infection is mild in the majority of individuals but progresses into severe pneumonia in a small proportion of patients. The increased…”
Get full text