Search Results - "van Zuylen, Wendy"
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Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy
Published in The Lancet infectious diseases (01-06-2017)“…Summary Congenital cytomegalovirus is the most frequent, yet under-recognised, infectious cause of newborn malformation in developed countries. Despite its…”
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Differential Expression of PDGF Receptor-α in Human Placental Trophoblasts Leads to Different Entry Pathways by Human Cytomegalovirus Strains
Published in Scientific reports (23-01-2020)“…Human cytomegalovirus (CMV) is the leading non-genetic cause of fetal malformation in developed countries. CMV placental infection is a pre-requisite for…”
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Macrophage activation and differentiation signals regulate schlafen-4 gene expression: evidence for Schlafen-4 as a modulator of myelopoiesis
Published in PloS one (07-01-2011)“…The ten mouse and six human members of the Schlafen (Slfn) gene family all contain an AAA domain. Little is known of their function, but previous studies…”
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Congenital cytomegalovirus infection in pregnancy: a review of prevalence, clinical features, diagnosis and prevention
Published in Australian & New Zealand journal of obstetrics & gynaecology (01-02-2016)“…Human cytomegalovirus (CMV) is under‐recognised, despite being the leading infectious cause of congenital malformation, affecting ~0.3% of Australian live…”
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Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity
Published in PLoS pathogens (01-07-2012)“…Tumor Necrosis Factor receptor-associated factor-3 (TRAF3) is a central mediator important for inducing type I interferon (IFN) production in response to…”
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High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I. Implications for T-cell receptor engagement and T-cell immunodominance
Published in The Journal of biological chemistry (24-06-2005)“…Although HLA class I alleles can bind epitopes up to 14 amino acids in length, little is known about the immunogenicity or the responding T-cell repertoire…”
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Expression of Gal4-dependent transgenes in cells of the mononuclear phagocyte system labeled with enhanced cyan fluorescent protein using Csf1r-Gal4VP16/UAS-ECFP double-transgenic mice
Published in Journal of leukocyte biology (01-02-2008)“…We generated double‐transgenic mice carrying cointegrated tissue‐specific Gal4 and Gal4 reporter transgenes to direct transgene overexpression in the…”
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Detection of Ganciclovir-Resistant Cytomegalovirus in a Prospective Cohort of Kidney Transplant Recipients Receiving Subtherapeutic Valganciclovir Prophylaxis
Published in Microbiology spectrum (06-06-2022)“…Cytomegalovirus infection during antiviral prophylaxis occurs in transplant recipients despite individualized regimens based on renal function. Fifty kidney…”
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Potent T cell response to a class I‐binding 13‐mer viral epitope and the influence of HLA micropolymorphism in controlling epitope length
Published in European Journal of Immunology (01-09-2004)“…The BZLF1 antigen of Epstein‐Barr virus includes three overlapping sequences of different lengths that conform to the binding motif of human leukocyte antigen…”
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Update on treatment of cytomegalovirus infection in pregnancy and of the newborn with congenital cytomegalovirus
Published in Current opinion in infectious diseases (01-12-2016)“…PURPOSE OF REVIEWThe purpose of this review is to assess the recent studies of therapy of pregnant women and neonates, aimed at preventing the consequences of…”
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Neonates with congenital Cytomegalovirus and hearing loss identified via the universal newborn hearing screening program
Published in Journal of clinical virology (01-05-2018)“…•Congenital CMV was diagnosed in 19/323 (5.9%) with confirmed hearing loss, of whom 11/323 infants had a definite diagnosis at <21 days of age.•CMV testing…”
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Cytomegalovirus infection in day care centres: A systematic review and meta‐analysis of prevalence of infection in children
Published in Reviews in medical virology (01-01-2019)“…Summary Maternofetal transmission of cytomegalovirus (CMV) is the most common infectious cause of congenital malformation in developed countries. Maternal…”
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The Wnt pathway: a key network in cell signalling dysregulated by viruses
Published in Reviews in medical virology (01-09-2016)“…Summary Viruses are obligate parasites dependent on host cells for survival. Viral infection of a cell activates a panel of pattern recognition receptors that…”
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Human Cytomegalovirus Modulates Expression of Noncanonical Wnt Receptor ROR2 To Alter Trophoblast Migration
Published in Journal of virology (15-01-2016)“…Maternal primary cytomegalovirus (CMV) infection, reactivation, or reinfection with a different viral strain may cause fetal injury and adverse pregnancy…”
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Patient-Derived Cytomegaloviruses with Different Ganciclovir Sensitivities from UL97 Mutation Retain Their Replication Efficiency and Some Kinase Activity In Vitro
Published in Antimicrobial agents and chemotherapy (01-09-2019)“…Mutations in the cytomegalovirus UL97 kinase gene contribute to antiviral resistance. Mutations A594S and G598D from two clinical isolates were analyzed, and…”
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Selective modulation of Wnt-binding receptor tyrosine kinase ROR2 expression by human cytomegalovirus regulates trophoblast migration
Published in Journal of general virology (01-01-2019)“…Cytomegalovirus (CMV) infection during pregnancy may lead to adverse pregnancy outcomes and permanent neurological disabilities in infants infected in utero…”
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Systematic review of ganciclovir pharmacodynamics during the prevention of cytomegalovirus infection in adult solid organ transplant recipients
Published in Reviews in medical virology (01-03-2019)“…Summary Human cytomegalovirus (CMV) represents the most common infection among recipients of solid organ transplants (SOTs). Previous meta‐analysis showed 0.8%…”
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Role of IκB Kinase-β in the Growth-Promoting Effects of Angiotensin II In Vitro and In Vivo
Published in Arteriosclerosis, thrombosis, and vascular biology (01-12-2013)“…OBJECTIVE—Angiotensin II (Ang II) is implicated in processes underlying the development of arterial wall remodeling events, including cellular hypertrophy and…”
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Congenital cytomegalovirus infection: Clinical presentation, epidemiology, diagnosis and prevention
Published in Obstetric Medicine (01-12-2014)“…Cytomegalovirus is the most common congenital infection causing serious disease in infants. It is the leading infectious cause of sensorineural hearing loss…”
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