Search Results - "van Zuydam, N."

A genome-wide association study suggests an association of Chr8p21.3 (GFRA2) with diabetic neuropathic pain by Meng, W., Deshmukh, H.A., van Zuydam, N.R., Liu, Y., Donnelly, L.A., Zhou, K., Morris, A.D., Colhoun, H.M., Palmer, C.N.A., Smith, B.H.

“…Background Neuropathic pain, caused by a lesion or a disease affecting the somatosensory system, is one of the most common complications in diabetic patients…”
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Cholesteryl Ester Transfer Protein Polymorphisms, Statin Use, and Their Impact on Cholesterol Levels and Cardiovascular Events by Leusink, M, Onland-Moret, N C, Asselbergs, F W, Ding, B, Kotti, S, van Zuydam, N R, Papp, A C, Danchin, N, Donnelly, L, Morris, A D, Chasman, D I, Doevendans, P A F M, Klungel, O H, Ridker, P M, van Gilst, W H, Simon, T, Nyberg, F, Palmer, C N A, Sadee, W, van der Harst, P, de Bakker, P I W, de Boer, A, Verstuyft, C, Maitland-van der Zee, A H

“…The association of nonfunctional variants of the cholesteryl ester transfer protein (CETP) with efficacy of statins has been a subject of debate. We evaluated…”
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Relative effects of LDL-C on ischemic stroke and coronary disease: A Mendelian randomization study by Valdes-Marquez, Elsa, Parish, Sarah, Clarke, Robert, Stari, Traiani, Worrall, Bradford B, Hopewell, Jemma C

“…OBJECTIVETo examine the causal relevance of lifelong differences in low-density lipoprotein cholesterol (LDL-C) for ischemic stroke (IS) relative to that for…”
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Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus by Mathieson, Iain, Day, Felix R., Tropf, Felix C., Brazel, David M., Vaez, Ahmad, van Zuydam, Natalie, Bitarello, Bárbara D., Gardner, Eugene J., Akimova, Evelina T., Azad, Ajuna, Bergmann, Sven, Bielak, Lawrence F., Boomsma, Dorret I., Bosak, Kristina, Brumat, Marco, Buring, Julie E., Cesarini, David, Chasman, Daniel I., Chavarro, Jorge E., Concas, Maria Pina, Davey Smith, George, Davies, Gail, Deary, Ian J., Esko, Tõnu, Faul, Jessica D., Franco, Oscar, Gaskins, Audrey J., Gelemanovic, Andrea, de Geus, Eco J. C., Gieger, Christian, Gopinath, Bamini, Grabe, Hans Jörgen, Gunderson, Erica P., Hayward, Caroline, He, Chunyan, van Heemst, Diana, Hill, W. David, Homuth, Georg, Hottenga, Jouke Jan, Huang, Hongyang, Hyppӧnen, Elina, Ikram, M. Arfan, Jansen, Rick, Johannesson, Magnus, Kardia, Sharon L. R., Kavousi, Maryam, Kifley, Annette, Kraft, Peter, Kühnel, Brigitte, Langenberg, Claudia, Liew, Gerald, Lind, Penelope A., Luan, Jian’an, Mägi, Reedik, Magnusson, Patrik K. E., Mahajan, Anubha, Martin, Nicholas G., McCarthy, Mark I., McMahon, George, Medland, Sarah E., Meitinger, Thomas, Metspalu, Andres, Mihailov, Evelin, Missmer, Stacey A., Mitchell, Paul, Møllegaard, Stine, Mook-Kanamori, Dennis O., van der Most, Peter J., de Mutsert, Renée, Nolte, Ilja M., Noordam, Raymond, Penninx, Brenda W. J. H., Peters, Annette, Peyser, Patricia A., Polašek, Ozren, Power, Chris, Pribisalic, Ajka, Rich-Edwards, Janet W., Ridker, Paul M., Ring, Susan M., Rose, Lynda M., Rueedi, Rico, Shukla, Vallari, Smith, Jennifer A., Stefánsson, Kári, Stöckl, Doris, Strauch, Konstantin, Swertz, Morris A., Teumer, Alexander, Thorleifsson, Gudmar, Waldenberger, Melanie, Wareham, Nicholas J., Willemsen, Gonneke, Zhao, Jing Hau, Zhao, Wei, Zhao, Yajie, Snieder, Harold, Ong, Ken K., Mills, Melinda C., Perry, John R. B.

“…Identifying genetic determinants of reproductive success may highlight mechanisms underlying fertility and identify alleles under present-day selection. Using…”
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Shared Genetic Contribution of Type 2 Diabetes and Cardiovascular Disease: Implications for Prognosis and Treatment by Strawbridge, Rona J., van Zuydam, Natalie R.

“…Purpose of Review The increased cardiovascular disease (CVD) risk in subjects with type 2 diabetes (T2D) is well established. This review collates the…”
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Known SNPs in ADAMTS7, the 9p21 region and UBE2E interact with type 2 diabetes status to modify the risk of coronary artery disease in large populations by van Zuydam, N. R., Voight, B., Ladenvall, C., Strawbridge, R., Willems, S., Hartiala, J., Vlacholpoulou, E., Mihailov, E., Kwee, L., Qu, L., Goel, A., Kumar, Jitender, Kanoni, S.

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Large-scale association analysis identifies new risk loci for coronary artery disease by Willenborg, Christina, Farrall, Martin, Assimes, Themistocles L, Thompson, John R, Ingelsson, Erik, Goldstein, Benjamin A, Stirrups, Kathleen, König, Inke R, Cazier, Jean-Baptiste, Lee, Jong-Young, Chambers, John C, Esko, Tõnu, Folkersen, Lasse, Havulinna, Aki S, Ho, Weang K, Hopewell, Jemma C, Shungin, Dmitry, Van Zuydam, Natalie, Voight, Benjamin F, Zhang, Weihua, Ziegler, Andreas, Altshuler, David, Balmforth, Anthony J, Dimitriou, Maria, Mokhtari, NourEddine El, Fischer, Krista, Fontanillas, Pierre, Franco-Cereceda, Anders, Groop, Leif, Hager, Jörg, Hallmans, Göran, Han, Bok-Ghee, Hunt, Sarah E, Kessler, Thorsten, Kuusisto, Johanna, Lokki, Marja-Liisa, Lundmark, Anders, McCarthy, Mark I, Meisinger, Christa, Melander, Olle, Mihailov, Evelin, Nikus, Kjell, Peden, John F, Rasheed, Asif, Rubin, Diana, Thorgeirsson, Gudmundur, Wells, George A, Wild, Philipp S, Yang, Tsun-Po, Amouyel, Philippe, Basart, Hanneke, Boehnke, Michael, Boerwinkle, Eric, Brambilla, Paolo, Cupples, Adrienne L, de Faire, Ulf, Epstein, Stephen E, Ferrario, Marco M, Ferrières, Jean, Go, Alan S, Gudnason, Villi, Hazen, Stanley L, Jang, Yangsoo, Kim, Hyo-Soo, Kratzer, Wolfgang, Kuulasmaa, Kari, Laaksonen, Reijo, Lee, Ji-Young, Park, Jeong E, Peters, Annette, Quertermous, Thomas, Salomaa, Veikko, Schadt, Eric, Shah, Svati H, Sinisalo, Juha, Stark, Klaus, Stefansson, Kari, Wallentin, Lars, Wareham, Nicholas, Hengstenberg, Christian, Sandhu, Manjinder S, Pastinen, Tomi, Syvänen, Ann-Christine, Hovingh, G Kees, Franks, Paul W, Lehtimäki, Terho, Siegbahn, Agneta, Schreiber, Stefan, Blankenberg, Stefan S, Perola, Markus, Clarke, Robert, O'Donnell, Christopher, Reilly, Muredach P, März, Winfried, Collins, Rory, Thorsteinsdottir, Unnur, Danesh, John, Palmer, Colin N A, Schunkert, Heribert, Samani, Nilesh J

“…Panos Deloukas, Nilesh Samani and colleagues report a large-scale association analysis using the Metabochip array in 63,746 coronary artery disease cases and…”
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Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen by Salem, Rany M, Todd, Jennifer N, Sandholm, Niina, Cole, Joanne B, Chen, Wei-Min, Andrews, Darrell, Pezzolesi, Marcus G, McKeigue, Paul M, Hiraki, Linda T, Qiu, Chengxiang, Nair, Viji, Di Liao, Chen, Cao, Jing Jing, Valo, Erkka, Onengut-Gumuscu, Suna, Smiles, Adam M, McGurnaghan, Stuart J, Haukka, Jani K, Harjutsalo, Valma, Brennan, Eoin P, van Zuydam, Natalie, Ahlqvist, Emma, Doyle, Ross, Ahluwalia, Tarunveer S, Lajer, Maria, Hughes, Maria F, Park, Jihwan, Skupien, Jan, Spiliopoulou, Athina, Liu, Andrew, Menon, Rajasree, Boustany-Kari, Carine M, Kang, Hyun M, Nelson, Robert G, Klein, Ronald, Klein, Barbara E, Lee, Kristine E, Gao, Xiaoyu, Mauer, Michael, Maestroni, Silvia, Caramori, Maria Luiza, de Boer, Ian H, Miller, Rachel G, Guo, Jingchuan, Boright, Andrew P, Tregouet, David, Gyorgy, Beata, Snell-Bergeon, Janet K, Maahs, David M, Bull, Shelley B, Canty, Angelo J, Palmer, Colin N A, Stechemesser, Lars, Paulweber, Bernhard, Weitgasser, Raimund, Sokolovska, Jelizaveta, Rovīte, Vita, Pīrāgs, Valdis, Prakapiene, Edita, Radzeviciene, Lina, Verkauskiene, Rasa, Panduru, Nicolae Mircea, Groop, Leif C, McCarthy, Mark I, Gu, Harvest F, Möllsten, Anna, Falhammar, Henrik, Brismar, Kerstin, Martin, Finian, Rossing, Peter, Costacou, Tina, Zerbini, Gianpaolo, Marre, Michel, Hadjadj, Samy, McKnight, Amy J, Forsblom, Carol, McKay, Gareth, Godson, Catherine, Maxwell, A Peter, Kretzler, Matthias, Susztak, Katalin, Colhoun, Helen M, Krolewski, Andrzej, Paterson, Andrew D, Groop, Per-Henrik, Rich, Stephen S, Hirschhorn, Joel N, Florez, Jose C

“…Although diabetic kidney disease demonstrates both familial clustering and single nucleotide polymorphism heritability, the specific genetic factors…”
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The sodium glucose co-transporter 2 inhibitor dapagliflozin ameliorates the fluid-retaining effect of the endothelin A receptor antagonist zibotentan by Veenit, Vandana, Heerspink, Hiddo J L, Ahlström, Christine, Greasley, Peter J, Skritic, Stanko, van Zuydam, Natalie, Kohan, Donald E, Hansen, Pernille B L, Menzies, Robert I

“…ABSTRACT Background Endothelin A receptor antagonists (ETARA) slow chronic kidney disease (CKD) progression but their use is limited due to fluid retention and…”
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Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions by Saleheen, Danish, Zhao, Wei, Young, Robin, Nelson, Christopher P, Ho, WeangKee, Ferguson, Jane F, Rasheed, Asif, Ou, Kristy, Nurnberg, Sylvia T, Bauer, Robert C, Goel, Anuj, Do, Ron, Stewart, Alexandre F.R, Hartiala, Jaana, Zhang, Weihua, Thorleifsson, Gudmar, Strawbridge, Rona J, Sinisalo, Juha, Kanoni, Stavroula, Sedaghat, Sanaz, Marouli, Eirini, Kristiansson, Kati, Hua Zhao, Jing, Scott, Robert, Gauguier, Dominique, Shah, Svati H, Smith, Albert Vernon, van Zuydam, Natalie, Cox, Amanda J, Willenborg, Christina, Kessler, Thorsten, Zeng, Lingyao, Province, Michael A, Ganna, Andrea, Lind, Lars, Pedersen, Nancy L, White, Charles C, Joensuu, Anni, Edi Kleber, Marcus, Hall, Alistair S, März, Winfried, Salomaa, Veikko, O’Donnell, Christopher, Ingelsson, Erik, Feitosa, Mary F, Erdmann, Jeanette, Bowden, Donald W, Palmer, Colin N.A, Gudnason, Vilmundur, Faire, Ulf De, Zalloua, Pierre, Wareham, Nicholas, Thompson, John R, Kuulasmaa, Kari, Dedoussis, George, Perola, Markus, Dehghan, Abbas, Chambers, John C, Kooner, Jaspal, Allayee, Hooman, Deloukas, Panos, McPherson, Ruth, Stefansson, Kari, Schunkert, Heribert, Kathiresan, Sekar, Farrall, Martin, Marcel Frossard, Philippe, Rader, Daniel J, Samani, Nilesh J, Reilly, Muredach P

“…BACKGROUND:Common diseases such as coronary heart disease (CHD) are complex in etiology. The interaction of genetic susceptibility with lifestyle factors may…”
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Protein biomarkers for the prediction of cardiovascular disease in type 2 diabetes by Looker, Helen C., Colombo, Marco, Agakov, Felix, Zeller, Tanja, Groop, Leif, Thorand, Barbara, Palmer, Colin N., Hamsten, Anders, de Faire, Ulf, Nogoceke, Everson, Livingstone, Shona J., Salomaa, Veikko, Leander, Karin, Barbarini, Nicola, Bellazzi, Riccardo, van Zuydam, Natalie, McKeigue, Paul M., Colhoun, Helen M.

“…Aims/hypothesis We selected the most informative protein biomarkers for the prediction of incident cardiovascular disease (CVD) in people with type 2 diabetes…”
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Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen: J Am Soc Nephrol by Salem, R. M., Todd, J. N., Sandholm, N., Cole, J. B., Chen, W. M., Andrews, D., Pezzolesi, M. G., Mckeigue, P. M., Hiraki, L. T., Qiu, C., Nair, V., Di Liao, C., Cao, J. J., Valo, E., Onengut-Gumuscu, S., Smiles, A. M., Mcgurnaghan, S. J., Haukka, J. K., Harjutsalo, V., Brennan, E. P., van Zuydam, N., Ahlqvist, E., Doyle, R., Ahluwalia, T. S., Lajer, M., Hughes, M. F., Park, J., Skupien, J., Spiliopoulou, A., Liu, A., Menon, R., Boustany-Kari, C. M., Kang, H. M., Nelson, R. G., Klein, R., Klein, B. E., Lee, K. E., Gao, X., Mauer, M., Maestroni, S., Caramori, M. L., de Boer, I. H., Miller, R. G., Guo, J., Boright, A. P., Tregouet, D., Gyorgy, B., Snell-Bergeon, J. K., Maahs, D. M., Bull, S. B., Canty, A. J., Palmer, C. N. A., Stechemesser, L., Paulweber, B., Weitgasser, R., Sokolovska, J., Rovite, V., Pirags, V., Prakapiene, E., Radzeviciene, L., Verkauskiene, R., Panduru, N. M., Groop, L. C., Mccarthy, M. I., Gu, H. F., Mollsten, A., Falhammar, H., Brismar, K., Martin, F., Rossing, P., Costacou, T., Zerbini, G., Marre, M., Hadjadj, S., Mcknight, A. J., Forsblom, C., Mckay, G., Godson, C., Maxwell, A. P., Kretzler, M., Susztak, K., Colhoun, H. M., Krolewski, A., Paterson, A. D., Groop, P. H., Rich, S. S., Hirschhorn, J. N., Florez, J. C.

“…BACKGROUND: Although diabetic kidney disease demonstrates both familial clustering and single nucleotide polymorphism heritability, the specific genetic…”
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A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes by van Zuydam, Natalie R, Ahlqvist, Emma, Sandholm, Niina, Deshmukh, Harshal, Rayner, N William, Abdalla, Moustafa, Ladenvall, Claes, Ziemek, Daniel, Fauman, Eric, Robertson, Neil R, McKeigue, Paul M, Valo, Erkka, Forsblom, Carol, Harjutsalo, Valma, Perna, Annalisa, Rurali, Erica, Marcovecchio, M Loredana, Igo, Jr, Robert P, Salem, Rany M, Perico, Norberto, Lajer, Maria, Käräjämäki, Annemari, Imamura, Minako, Kubo, Michiaki, Takahashi, Atsushi, Sim, Xueling, Liu, Jianjun, van Dam, Rob M, Jiang, Guozhi, Tam, Claudia H T, Luk, Andrea O Y, Lee, Heung Man, Lim, Cadmon K P, Szeto, Cheuk Chun, So, Wing Yee, Chan, Juliana C N, Ang, Su Fen, Dorajoo, Rajkumar, Wang, Ling, Clara, Tan Si Hua, McKnight, Amy-Jayne, Duffy, Seamus, Pezzolesi, Marcus G, Marre, Michel, Gyorgy, Beata, Hadjadj, Samy, Hiraki, Linda T, Ahluwalia, Tarunveer S, Almgren, Peter, Schulz, Christina-Alexandra, Orho-Melander, Marju, Linneberg, Allan, Christensen, Cramer, Witte, Daniel R, Grarup, Niels, Brandslund, Ivan, Melander, Olle, Paterson, Andrew D, Tregouet, David, Maxwell, Alexander P, Lim, Su Chi, Ma, Ronald C W, Tai, E Shyong, Maeda, Shiro, Lyssenko, Valeriya, Tuomi, Tiinamaija, Krolewski, Andrzej S, Rich, Stephen S, Hirschhorn, Joel N, Florez, Jose C, Dunger, David, Pedersen, Oluf, Hansen, Torben, Rossing, Peter, Remuzzi, Giuseppe, Brosnan, Mary Julia, Palmer, Colin N A, Groop, Per-Henrik, Colhoun, Helen M, Groop, Leif C, McCarthy, Mark I

“…Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the…”
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Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease by Persson, Jonas, Strawbridge, Rona J, McLeod, Olga, Gertow, Karl, Silveira, Angela, Baldassarre, Damiano, Van Zuydam, Natalie, Shah, Sonia, Fava, Cristiano, Gustafsson, Stefan, Veglia, Fabrizio, Sennblad, Bengt, Larsson, Malin, Sabater-Lleal, Maria, Leander, Karin, Gigante, Bruna, Tabak, Adam, Kivimaki, Mika, Kauhanen, Jussi, Rauramaa, Rainer, Smit, Andries J, Mannarino, Elmo, Giral, Philippe, Humphries, Steve E, Tremoli, Elena, de Faire, Ulf, Lind, Lars, Ingelsson, Erik, Hedblad, Bo, Melander, Olle, Kumari, Meena, Hingorani, Aroon, Morris, Andrew D, Palmer, Colin N A, Lundman, Pia, Öhrvik, John, Söderberg, Stefan, Hamsten, Anders

“…Plasma adiponectin levels have previously been inversely associated with carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis. In this…”
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Cholesteryl EsterTransfer Protein Polymorphisms, Statin Use, and Their Impact on Cholesterol Levels and Cardiovascular Events by LEUSINK, M, ONLAND-MORET, N. C, CHASMAN, D. I, DOEVENDANS, P. A. F. M, KLUNGEL, O. H, RIDKER, P. M, VAN GILST, W. H, SIMON, T, NYBERG, F, PALMER, C. N. A, SADEE, W, VAN DER HARST, P, ASSELBERGS, F. W, DE BAKKER, P. I. W, DE BOER, A, VERSTUYFT, C, MAITLAND-VAN DER ZEE, A. H, DING, B, KOTTI, S, VAN ZUYDAM, N. R, PAPP, A. C, DANCHIN, N, DONNELLY, L, MORRIS, A. D

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A Gene-by-Environment Analysis of 184,428 Subjects Reveals a Role for Adaptive and Innate Immunity in Coronary Artery Disease in Subjects with Type 2 Diabetes by van Zuydam, Natalie R., Voight, Benjamin F., Ladenvall, Claes, Fernandez, Juan, Strawbridge, Rona J.

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A signal near TMEM170A is associated with coronary artery disease and SNPs near IL15RA/IL2RA and THY1 may interact with diabetes status to modify the risk of CAD by van Zuydam, NR, Voight, B, Ladenvall, C, Strawbridge, R, Willems, S, van Iperen, E, Hartiala, J, Vlachopoulou, E, Mihailov, E, Kwee, L, Nelson, C, Kleber, M, Qu, L, Goel, A, Kanoni, S

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A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease by Nikpay, Majid, Goel, Anuj, Won, Hong-Hee, Hall, Leanne M, Willenborg, Christina, Kanoni, Stavroula, Saleheen, Danish, Kyriakou, Theodosios, Nelson, Christopher P, Hopewell, Jemma C, Webb, Thomas R, Zeng, Lingyao, Dehghan, Abbas, Alver, Maris, Armasu, Sebastian M, Auro, Kirsi, Bjonnes, Andrew, Chasman, Daniel I, Chen, Shufeng, Ford, Ian, Franceschini, Nora, Gieger, Christian, Grace, Christopher, Gustafsson, Stefan, Huang, Jie, Hwang, Shih-Jen, Kim, Yun Kyoung, Kleber, Marcus E, Lau, King Wai, Lu, Xiangfeng, Lu, Yingchang, Lyytikäinen, Leo-Pekka, Mihailov, Evelin, Morrison, Alanna C, Pervjakova, Natalia, Qu, Liming, Rose, Lynda M, Salfati, Elias, Saxena, Richa, Scholz, Markus, Smith, Albert V, Tikkanen, Emmi, Uitterlinden, Andre, Yang, Xueli, Zhang, Weihua, Zhao, Wei, de Andrade, Mariza, de Vries, Paul S, van Zuydam, Natalie R, Anand, Sonia S, Bertram, Lars, Beutner, Frank, Dedoussis, George, Frossard, Philippe, Gauguier, Dominique, Goodall, Alison H, Gottesman, Omri, Haber, Marc, Han, Bok-Ghee, Huang, Jianfeng, Jalilzadeh, Shapour, Kessler, Thorsten, König, Inke R, Lannfelt, Lars, Lieb, Wolfgang, Lind, Lars, Lindgren, Cecilia M, Lokki, Marja-Liisa, Magnusson, Patrik K, Mallick, Nadeem H, Mehra, Narinder, Meitinger, Thomas, Memon, Fazal-Ur-Rehman, Morris, Andrew P, Nieminen, Markku S, Pedersen, Nancy L, Peters, Annette, Rallidis, Loukianos S, Rasheed, Asif, Samuel, Maria, Shah, Svati H, Sinisalo, Juha, Stirrups, Kathleen E, Trompet, Stella, Wang, Laiyuan, Zaman, Khan S, Ardissino, Diego, Boerwinkle, Eric, Borecki, Ingrid B, Bottinger, Erwin P, Buring, Julie E, Chambers, John C, Collins, Rory, Cupples, L Adrienne, Danesh, John, Demuth, Ilja, Elosua, Roberto, Epstein, Stephen E, Esko, Tõnu, Feitosa, Mary F

“…Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of…”
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