Search Results - "van Wilgenburg, Bonnie"

Efficient, long term production of monocyte-derived macrophages from human pluripotent stem cells under partly-defined and fully-defined conditions by van Wilgenburg, Bonnie, Browne, Cathy, Vowles, Jane, Cowley, Sally A

“…Human macrophages are specialised hosts for HIV-1, dengue virus, Leishmania and Mycobacterium tuberculosis. Yet macrophage research is hampered by lack of…”
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MAIT cells contribute to protection against lethal influenza infection in vivo by van Wilgenburg, Bonnie, Loh, Liyen, Chen, Zhenjun, Pediongco, Troi J., Wang, Huimeng, Shi, Mai, Zhao, Zhe, Koutsakos, Marios, Nüssing, Simone, Sant, Sneha, Wang, Zhongfang, D’Souza, Criselle, Jia, Xiaoxiao, Almeida, Catarina F., Kostenko, Lyudmila, Eckle, Sidonia B. G., Meehan, Bronwyn S., Kallies, Axel, Godfrey, Dale I., Reading, Patrick C., Corbett, Alexandra J., McCluskey, James, Klenerman, Paul, Kedzierska, Katherine, Hinks, Timothy S. C.

“…Mucosal associated invariant T (MAIT) cells are evolutionarily-conserved, innate-like lymphocytes which are abundant in human lungs and can contribute to…”
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Unique and Common Features of Innate-Like Human Vδ2 + γδT Cells and Mucosal-Associated Invariant T Cells by Provine, Nicholas M, Binder, Benedikt, FitzPatrick, Michael E B, Schuch, Anita, Garner, Lucy C, Williamson, Kate D, van Wilgenburg, Bonnie, Thimme, Robert, Klenerman, Paul, Hofmann, Maike

“…Mucosal-associated invariant T (MAIT) cells are innate-like T cells abundant in humans that can be activated in a TCR-independent manner by inflammatory and…”
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MAIT cells are activated during human viral infections by van Wilgenburg, Bonnie, Scherwitzl, Iris, Hutchinson, Edward C., Leng, Tianqi, Kurioka, Ayako, Kulicke, Corinna, de Lara, Catherine, Cole, Suzanne, Vasanawathana, Sirijitt, Limpitikul, Wannee, Malasit, Prida, Young, Duncan, Denney, Laura, Moore, Michael D., Fabris, Paolo, Giordani, Maria Teresa, Oo, Ye Htun, Laidlaw, Stephen M., Dustin, Lynn B., Ho, Ling-Pei, Thompson, Fiona M., Ramamurthy, Narayan, Mongkolsapaya, Juthathip, Willberg, Christian B., Screaton, Gavin R., Klenerman, Paul

“…Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated…”
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Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1 by Jeffery, Hannah C, van Wilgenburg, Bonnie, Kurioka, Ayako, Parekh, Krishan, Stirling, Kathryn, Roberts, Sheree, Dutton, Emma E, Hunter, Stuart, Geh, Daniel, Braitch, Manjit K, Rajanayagam, Jeremy, Iqbal, Tariq, Pinkney, Thomas, Brown, Rachel, Withers, David R, Adams, David H, Klenerman, Paul, Oo, Ye H

“…Background & Aims Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells characterised by the invariant TCR-chain, Vα7.2-Jα33, and are restricted…”
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Mapping the European startup landscape by van Wilgenburg, Bonnie, van Wilgenburg, Kim, Paisner, Kathryn, van Deventer, Sander, Rooswinkel, Rogier W.

“…A deep dive into the influence of research output, patenting, venture capital and human capital on startup financing activity in Europe reveals not all…”
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Nanopore sequencing and full genome de novo assembly of human cytomegalovirus TB40/E reveals clonal diversity and structural variations by Karamitros, Timokratis, van Wilgenburg, Bonnie, Wills, Mark, Klenerman, Paul, Magiorkinis, Gkikas

“…Human cytomegalovirus (HCMV) has a double-stranded DNA genome of approximately 235 Kbp that is structurally complex including extended GC-rich repeated…”
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Successful direct‐acting antiviral therapy in HIV/HCV co‐infected patients fails to restore circulating mucosal‐associated invariant T cells by Cannizzo, Elvira Stefania, Cerrone, Maddalena, Merlini, Esther, Wilgenburg, Bonnie, Swadling, Leo, Ancona, Giuseppe, Bona, Anna, d'Arminio Monforte, Antonella, Klenerman, Paul, Marchetti, Giulia

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CD161 Defines a Functionally Distinct Subset of Pro-Inflammatory Natural Killer Cells by Kurioka, Ayako, Cosgrove, Cormac, Simoni, Yannick, van Wilgenburg, Bonnie, Geremia, Alessandra, Björkander, Sophia, Sverremark-Ekström, Eva, Thurnheer, Christine, Günthard, Huldrych F, Khanna, Nina, Walker, Lucy Jane, Arancibia-Cárcamo, Carolina V, Newell, Evan W, Willberg, Christian B, Klenerman, Paul

“…CD161 is a C-type lectin-like receptor expressed on the majority of natural killer (NK) cells; however, the significance of CD161 expression on NK cells has…”
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Association Between Impaired Vα7.2+CD161++CD8+ (MAIT) and Vα7.2+CD161-CD8+ T-Cell Populations and Gut Dysbiosis in Chronically HIV- and/or HCV-Infected Patients by Merlini, Esther, Cerrone, Maddalena, van Wilgenburg, Bonnie, Swadling, Leo, Cannizzo, E Stefania, d'Arminio Monforte, Antonella, Klenerman, Paul, Marchetti, Giulia

“…Both HIV and HCV infections feature increased microbial translocation (MT) and gut dysbiosis that affect immune homeostasis and disease outcome. Given their…”
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The productive entry pathway of HIV-1 in macrophages is dependent on endocytosis through lipid rafts containing CD4 by van Wilgenburg, Bonnie, Moore, Michael D, James, William S, Cowley, Sally A

“…Macrophages constitute an important reservoir of HIV-1 infection, yet HIV-1 entry into these cells is poorly understood due to the difficulty in genetically…”
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Protein kinase C and NF-κB-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infection by Raposo, Rui André Saraiva, Trudgian, David C, Thomas, Benjamin, van Wilgenburg, Bonnie, Cowley, Sally A, James, William

“…Upon activation, CD4(+) T cells release cytokines, chemokines, and other soluble factors that influence the kinetics of HIV-1 replication in macrophages (M)…”
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Epstein-Barr Virus Isolates Retain Their Capacity To Evade T Cell Immunity through BNLF2a despite Extensive Sequence Variation by HORST, Daniëlle, BURROWS, Scott R, GATHERER, Derek, VAN WILGENBURG, Bonnie, BELL, Melissa J, BOER, Ingrid G. J, RESSING, Maaike E, WIERTZ, Emmanuel J. H. J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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TLR signaling in human antigen‐presenting cells regulates MR1‐dependent activation of MAIT cells by Ussher, James E., Wilgenburg, Bonnie, Hannaway, Rachel F., Ruustal, Kerstin, Phalora, Prabhjeet, Kurioka, Ayako, Hansen, Ted H., Willberg, Christian B., Phillips, Rodney E., Klenerman, Paul

“…Mucosal‐associated invariant T (MAIT) cells are an abundant innate‐like T lymphocyte population that are enriched in liver and mucosal tissues. They are…”
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Diverse Streptococcus pneumoniae Strains Drive a Mucosal-Associated Invariant T-Cell Response Through Major Histocompatibility Complex class I-Related Molecule-Dependent and Cytokine-Driven Pathways by Kurioka, Ayako, van Wilgenburg, Bonnie, Javan, Reza Rezaei, Hoyle, Ryan, van Tonder, Andries J, Harrold, Caroline L, Leng, Tianqi, Howson, Lauren J, Shepherd, Dawn, Cerundolo, Vincenzo, Brueggemann, Angela B, Klenerman, Paul

“…Mucosal-associated invariant T (MAIT) cells represent an innate T-cell population that can recognize ligands generated by the microbial riboflavin synthesis…”
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Study of MAIT Cell Activation in Viral Infections In Vivo by Hinks, Timothy S C, van Wilgenburg, Bonnie, Wang, Huimeng, Loh, Liyen, Koutsakos, Marios, Kedzierska, Katherine, Corbett, Alexandra J, Chen, Zhenjun

“…MAIT cells are abundant, highly evolutionarily conserved innate-like lymphocytes expressing a semi-invariant T cell receptor (TCR), which recognizes…”
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Protein Kinase C and NF-κB-dependent CD4 down-regulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infection by Raposo, Rui André Saraiva, Trudgian, David C., Thomas, Benjamin, van Wilgenburg, Bonnie, Cowley, Sally A., James, William

“…Upon activation, CD4 + T cells release cytokines, chemokines and other soluble factors that influence the kinetics of HIV-1 replication in macrophages (Mϕ)…”
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Efficient, Long Term Production of Monocyte-Derived Macrophages from Human Pluripotent Stem Cells under Partly-Defined and Fully-Defined Conditions. e71098 by Wilgenburg, Bonnie van, Browne, Cathy, Vowles, Jane, Cowley, Sally A

“…Human macrophages are specialised hosts for HIV-1, dengue virus, Leishmania and Mycobacterium tuberculosis. Yet macrophage research is hampered by lack of…”
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The Productive Entry Pathway of HIV-1 in Macrophages Is Dependent on Endocytosis through Lipid Rafts Containing CD4: e86071 by Wilgenburg, Bonnie van, Moore, Michael D, James, William S, Cowley, Sally A

“…Macrophages constitute an important reservoir of HIV-1 infection, yet HIV-1 entry into these cells is poorly understood due to the difficulty in genetically…”
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Several commercially available anti-CCR5 monoclonal antibodies lack specificity and should be used with caution by Bernstone, Laura, van Wilgenburg, Bonnie, James, William

“…CCR5 (CD195) is a receptor for the chemokines RANTES, MIP-1α, and MIP-1β and is used by HIV-1 as a co-receptor for entry into macrophages and CD4+ T cells…”
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