Accumulation of adverse childhood events and overweight in children: A systematic review and meta‐analysis
Objective This study systematically summarizes the evidence of all observational studies investigating the relation between accumulation of adverse life events and measures of overweight in children <18 years. Methods MEDLINE, Embase, PsycINFO, and CINAHL were systematically searched (last search...
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| Published in: | Obesity (Silver Spring, Md.) Vol. 25; no. 5; pp. 820 - 832 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Blackwell Publishing Ltd
01-05-2017
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Objective
This study systematically summarizes the evidence of all observational studies investigating the relation between accumulation of adverse life events and measures of overweight in children <18 years.
Methods
MEDLINE, Embase, PsycINFO, and CINAHL were systematically searched (last search date 18 February 2015). The Newcastle‐Ottawa Scale was used for methodological quality assessment. Study estimates were pooled using a random‐effects model, and sources of heterogeneity were explored (PROSPERO registration number CRD42014014927).
Results
Eighteen articles were included, containing five longitudinal (n = 6,361) and fourteen cross‐sectional and case‐control study results (n = 52,318). The pooled estimate of the longitudinal studies showed that accumulation of adverse life events is positively related to childhood overweight measures (OR [95% CI] = 1.12 [1.01‐1.25]). Cross‐sectional and case‐control study results were heterogeneous. Subgroup analyses showed that cross‐sectional and case‐control studies using a continuous adverse events measure, studies using a continuous overweight measure, and studies in children >6‐12 years also generated positive pooled estimates, while the pooled estimate of studies assessing recent adverse events (past 2 years) was indicative of no relation with overweight.
Conclusions
Accumulation of adverse life events and childhood overweight measures are positively associated. However, increases in overweight measures in response to adverse childhood events do not seem to occur instantaneously. |
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| Bibliography: | This work was supported by a grant of the Graduate School of Medical Sciences of the University Medical Center Groningen awarded to LK Elsenburg and by the multidisciplinary research program Healthy Ageing, Population & Society (HAPS). HAPS is supported by the University of Groningen. The authors declared no conflict of interest. LKE conceptualized and designed the study, developed the search strategy, conducted the study selection, quality assessment, and data extraction, carried out initial analyses, drafted the initial manuscript, and approved the final manuscript as submitted. KJEvW conducted the study selection, quality assessment, and data extraction, reviewed and revised the manuscript, and approved the final manuscript as submitted. ACL conceptualized and designed the study, reviewed and revised the manuscript, and approved the final manuscript as submitted. NS conceptualized and designed the study, provided support with the search strategy, study selection, and quality assessment, reviewed and revised the manuscript, and approved the final manuscript as submitted. Disclosure Funding agencies Author contributions ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-4 content type line 23 ObjectType-Undefined-3 |
| ISSN: | 1930-7381 1930-739X |
| DOI: | 10.1002/oby.21797 |