Search Results - "van Wessem, Karlijn J.P."

Mechanical ventilation is the determining factor in inducing an inflammatory response in a hemorrhagic shock model by van Wessem, Karlijn J.P., MD, Hennus, Marije P., MD, Heeres, Marjolein, MD, Koenderman, Leo, PhD, Leenen, Luke P.H., MD, PhD

“…Abstract Background Hemorrhagic shock (HS) is known to induce an inflammatory response by activating the immune system. This response is mainly caused by…”
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Reduction in Mortality Rates of Postinjury Multiple Organ Dysfunction Syndrome: A Shifting Paradigm? A Prospective Population-Based Cohort Study by van Wessem, Karlijn J.P, Leenen, Luke P.H

“…INTRODUCTION:The incidence of multiple organ dysfunction syndrome (MODS) has decreased in the last decade by improvement in trauma care. However, it still…”
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Two-year mortality and end-of-life decisions after traumatic spinal cord injury: data from a Level 1 Trauma centre in the Netherlands by Niemeyer, Menco J.S., Peuker, Felix, Sadiqi, Said, Kerckhoffs, Monika C., Houwert, R. Marijn, Van Wessem, Karlijn J.P., Post, Marcel W.M., Stolwijk, Janneke M.

“…Objective: Literature shows high in-hospital mortality rates following end-of-life decisions in patients with traumatic spinal cord injury. This study…”
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A Rise in Neutrophil Cell Size Precedes Organ Dysfunction After Trauma by Hesselink, Lillian, Heeres, Marjolein, Paraschiakos, Fotis, ten Berg, Maarten, Huisman, Albert, Hoefer, Imo E, de Groot, Mark C.H, van Solinge, Wouter W, Dijkgraaf, Marcel, Hellebrekers, Pien, Van Wessem, Karlijn J.P, Koenderman, Leo, Leenen, Luke P.H, Hietbrink, Falco

“…INTRODUCTION:Organ dysfunction remains a major cause of morbidity after trauma. The development of organ dysfunction is determined by the inflammatory…”
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Fragile neutrophils in surgical patients: A phenomenon associated with critical illness by Hesselink, Lillian, Spijkerman, Roy, Hellebrekers, Pien, van Bourgondiën, Robert J, Blasse, Enja, Haitjema, Saskia, Huisman, Albert, van Solinge, Wouter W, Van Wessem, Karlijn J.P, Koenderman, Leo, Leenen, Luke P.H, Hietbrink, Falco

“…Leukocyte viability (determined by e.g. propidium iodide [PI] staining) is automatically measured by hematology analyzers to check for delayed bench time…”
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Attenuation of MODS-related and ARDS-related mortality makes infectious complications a remaining challenge in the severely injured by van Wessem, Karlijn J.P., Hietbrink, Falco, Leenen, Luke P.H.

“…IntroductionThe recent decrease in multiple organ dysfunction syndrome (MODS)-associated and adult respiratory distress syndrome (ARDS)-associated mortality…”
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Mechanical ventilation increases the inflammatory response induced by lung contusion by van Wessem, Karlijn J.P., MD, Hennus, Marije P., MD, van Wagenberg, Linda, MD, Koenderman, Leo, PhD, Leenen, Luke P.H., MD, PhD

“…Abstract Background Posttraumatic lung contusion is common after blunt chest trauma, and patients often need ventilatory support. Lung contusion induces an…”
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Selective faecal diversion in open pelvic fractures: Reassessment based on recent experience by van Wessem, Karlijn J.P, Mackay, Peter J, King, Kate L, Balogh, Zsolt J

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Epidemiology of Traumatic Deaths: Comprehensive Population-Based Assessment by Evans, Julie A., van Wessem, Karlijn J. P., McDougall, Debra, Lee, Kevin A., Lyons, Timothy, Balogh, Zsolt J.

“…Background The epidemiology of traumatic deaths was periodically described during the development of the American trauma system between 1977 and 1995…”
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Does Liberal Prehospital and In-Hospital Tranexamic Acid Influence Outcome in Severely Injured Patients? A Prospective Cohort Study by van Wessem, Karlijn J. P., Leenen, Luke P. H.

“…Background Early hemorrhage control is important in trauma-related death prevention. Tranexamic acid (TXA) has shown to be beneficial in patients in…”
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Process related decisions and in-hospital transport times in polytrauma patients benefit from 24/7 in-house presence of trauma surgeons by van Wessem, Karlijn J.P., Leenen, Luke P.H.

“…•Decisions for in-hospital transport order based on clinical signs in primary survey were rapid and accurate.•Possible preventable death was 1% in this…”
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Current treatment and outcomes of traumatic sternal fractures—a systematic review by Klei, Dorine S., de Jong, Mirjam B., Öner, F. Cumhur, Leenen, Luke P. H., van Wessem, Karlijn J. P.

“…Purpose Traumatic sternal fractures are rare injuries. The most common mechanism of injury is direct blunt trauma to the anterior chest wall. Most (> 95%)…”
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Global changes in mortality rates in polytrauma patients admitted to the ICU-a systematic review by van Breugel, Johanna M M, Niemeyer, Menco J S, Houwert, Roderick M, Groenwold, Rolf H H, Leenen, Luke P H, van Wessem, Karlijn J P

“…Many factors of trauma care have changed in the last decades. This review investigated the effect of these changes on global all-cause and cause-specific…”
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Incidence, causes and consequences of moderate and severe traumatic brain injury as determined by Abbreviated Injury Score in the Netherlands by Jochems, Denise, van Rein, Eveline, Niemeijer, Menco, van Heijl, Mark, van Es, Michael A., Nijboer, Tanja, Leenen, Luke P. H., Houwert, R. Marijn, van Wessem, Karlijn J. P.

“…Traumatic brain injury (TBI) is a leading cause of death and disability. Epidemiology seems to be changing. TBIs are increasingly caused by falls amongst…”
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Polytrauma patients with severe cervical spine injuries are different than with severe TBI despite similar AIS scores by van Wessem, Karlijn J. P., Niemeyer, Menco J. S., Leenen, Luke P. H.

“…Traumatic cervical spine injuries (TCSI) are rare injuries. With increasing age the incidence of TCSI is on the rise. TCSI and traumatic brain injury (TBI) are…”
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Letter to the editor regarding Latent class analysis to predict intensive care outcomes in Acute Respiratory Distress Syndrome: a proposal of two pulmonary phenotypes by van Wessem, Karlijn J. P, Leenen, Luke P. H

“…Mortality difference between both phenotypes is likely caused by the host’s reaction on the underlying inflammatory response. Since classification should serve…”
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Demographic Patterns and Outcomes of Patients in Level I Trauma Centers in Three International Trauma Systems by Gunning, Amy C., Lansink, Koen W. W., van Wessem, Karlijn J. P., Balogh, Zsolt J., Rivara, Frederick P., Maier, Ronald V., Leenen, Luke P. H.

“…Introduction Trauma systems were developed to improve the care for the injured. The designation and elements comprising these systems vary across countries. In…”
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Comments on article "Discrepancies between conventional and viscoelastic assays in identifying trauma induced coagulopathy" by van Wessem, Karlijn J.P., Leenen, Luke P.H.

“…•Comment on paper ‘’discrepancies between conventional and viscoelastic assays in identifying trauma induced coagulopathy’’.•Controversies in viscoelastic…”
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Point-of-Care Analysis of Neutrophil Phenotypes: A First Step Toward Immuno-Based Precision Medicine in the Trauma ICU by Spijkerman, Roy, Hesselink, Lillian, Bongers, Suzanne, van Wessem, Karlijn J P, Vrisekoop, Nienke, Hietbrink, Falco, Koenderman, Leo, Leenen, Luke P H

“…The amount of tissue damage and the amplitude of the immune response after trauma are related to the development of infectious complications later on. Changes…”
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Early correction of base deficit decreases late mortality in polytrauma by van Wessem, Karlijn J. P., Hietbrink, Falco, Leenen, Luke P. H.

“…Introduction Physiology-driven resuscitation has become the standard of care in severely injured patients. This has resulted in a decrease in acute deaths by…”
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