Search Results - "van Wely, Karel H. M"

Chromatin condensation and recruitment of PHD finger proteins to histone H3K4me3 are mutually exclusive by Gatchalian, Jovylyn, Gallardo, Carmen Mora, Shinsky, Stephen A, Ospina, Ruben Rosas, Liendo, Andrea Mansilla, Krajewski, Krzysztof, Klein, Brianna J, Andrews, Forest H, Strahl, Brian D, M van Wely, Karel H, Kutateladze, Tatiana G

“…Histone post-translational modifications, and specific combinations they create, mediate a wide range of nuclear events. However, the mechanistic bases for…”
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Hepatitis, testicular degeneration, and ataxia in DIDO3-deficient mice with altered mRNA processing by Gutiérrez, Julio, van Wely, Karel H M, Martínez-A, Carlos

“…mRNA processing is an essential step of gene expression; its malfunction can lead to different degrees of physiological disorder from subclinical disease to…”
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Correction to: Hepatitis, testicular degeneration, and ataxia in DIDO3-deficient mice with altered mRNA processing by Gutiérrez, Julio, van Wely, Karel H. M, Martínez-A, Carlos

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Dido disruption leads to centrosome amplification and mitotic checkpoint defects compromising chromosome stability by Trachana, Varvara, van Wely, Karel H.M, Guerrero, Astrid Alonso, Fütterer, Agnes, Martínez-A, Carlos

“…Numerical and/or structural centrosome abnormalities have been correlated with most solid tumors and hematological malignancies. Tumorigenesis also is linked…”
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Centromere fission, not telomere erosion, triggers chromosomal instability in human carcinomas by MARTINEZ-A, Carlos, VAN WELY, Karel H. M

“…The majority of sporadic carcinomas suffer from a kind of genetic instability in which chromosome number changes occur together with segmental defects. This…”
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Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle by Guerrero, Astrid Alonso, Gamero, Mercedes Cano, Trachana, Varvara, Fütterer, Agnes, Pacios-Bras, Cristina, Díaz-Concha, Nuria Panadero, Cigudosa, Juan Cruz, Martínez-A., Carlos, van Wely, Karel H.M

“…Most carcinomas present some form of chromosome instability in combination with spindle defects. Numerical instability is likely caused by spindle aberrations,…”
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Dido3-dependent SFPQ recruitment maintains efficiency in mammalian alternative splicing by Mora Gallardo, Carmen, Sánchez de Diego, Ainhoa, Gutiérrez Hernández, Julio, Talavera-Gutiérrez, Amaia, Fischer, Thierry, Martínez-A, Carlos, van Wely, Karel H M

“…Alternative splicing is facilitated by accessory proteins that guide spliceosome subunits to the primary transcript. Many of these splicing factors recognize…”
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How to make the end of a gene, the simple way by H. M. VAN WELY, KAREL

“…Transcription termination of nearly all protein-coding genes in mammals requires 3’ end processing by a multiprotein complex that will cleave and polyadenylate…”
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The leukemia-associated fusion protein MN1-TEL blocks TEL-specific recognition sequences by ter Haar, W Martijn, Meester-Smoor, Magda A, van Wely, Karel H M, Schot, Claudia C M M, Janssen, Marjolein J F W, Geverts, Bart, Bonten, Jacqueline, Grosveld, Gerard C, Houtsmuller, Adriaan B, Zwarthoff, Ellen C

“…The leukemia-associated fusion protein MN1-TEL combines the transcription-activating domains of MN1 with the DNA-binding domain of the transcriptional…”
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The ETS family member TEL binds to nuclear receptors RAR and RXR and represses gene activation by Meester-Smoor, Magda A, Janssen, Marjolein J F W, ter Haar, W Martijn, van Wely, Karel H M, Aarnoudse, Albert-Jan L H J, van Oord, Gertine, van Tilburg, Gabrielle B A, Zwarthoff, Ellen C

“…Retinoic acid receptor (RAR) signaling is important for regulating transcriptional activity of genes involved in growth, differentiation, metabolism and…”
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Targeted Disruption of the Mn1 Oncogene Results in Severe Defects in Development of Membranous Bones of the Cranial Skeleton by Meester-Smoor, Magda A., Vermeij, Marcel, van Helmond, Marjolein J. L., Molijn, Anco C., van Wely, Karel H. M., Hekman, Arnold C. P., Vermey-Keers, Christl, Riegman, Peter H. J., Zwarthoff, Ellen C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Synaptonemal complex assembly and H3K4Me3 demethylation determine DIDO3 localization in meiosis by Prieto, Ignacio, Kouznetsova, Anna, Fütterer, Agnes, Trachana, Varvara, Leonardo, Esther, Alonso Guerrero, Astrid, Cano Gamero, Mercedes, Pacios-Bras, Cristina, Leh, Hervé, Buckle, Malcolm, Garcia-Gallo, Mónica, Kremer, Leonor, Serrano, Antonio, Roncal, Fernando, Albar, Juan Pablo, Barbero, José Luis, Martínez-A, Carlos, van Wely, Karel H. M

“…Synapsis of homologous chromosomes is a key meiotic event, mediated by a large proteinaceous structure termed the synaptonemal complex. Here, we describe a…”
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Insulin-like Growth Factor-I and its Receptor in Neovascular Age-Related Macular Degeneration by Lambooij, Antoinette C, van Wely, Karel H. M, Lindenbergh-Kortleve, Dicky J, Kuijpers, Robert W. A. M, Kliffen, Mike, Mooy, Cornelia M

“…The insulin-like growth factor (IGF)-I protein is a growth-promoting polypeptide that can act as an angiogenic agent in the eye. The purpose of the current…”
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Suppressor of cytokine signaling 1 blocks mitosis in human melanoma cells by Parrillas, Verónica, Martínez-Muñoz, Laura, Holgado, Borja L, Kumar, Amit, Cascio, Graciela, Lucas, Pilar, Rodríguez-Frade, José Miguel, Malumbres, Marcos, Carrera, Ana C, van Wely, Karel HM, Mellado, Mario

“…Hypermethylation of SOCS genes is associated with many human cancers, suggesting a role as tumor suppressors. As adaptor molecules for ubiquitin ligases, SOCS…”
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DIDO is necessary for the adipogenesis that promotes diet-induced obesity by García-López, María Ángeles, Mora, Alfonso, Corrales, Patricia, Pons, Tirso, Sánchez de Diego, Ainhoa, Talavera Gutiérrez, Amaia, van Wely, Karel H M, Medina-Gómez, Gema, Sabio, Guadalupe, Martínez-A, Carlos, Fischer, Thierry

“…The prevalence of overweight and obesity continues to rise in the population worldwide. Because it is an important predisposing factor for cancer,…”
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The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription by VAN WELY, Karel H. M, MOLIJN, Anco C, BUIJS, Arjan, MEESTER-SMOOR, Magda A, AARNOUDSE, Albert Jan, HELLEMONS, Anita, DEN BESTEN, Pim, GROSVELD, Gerard C, ZWARTHOFF, Ellen C

“…The t(12;22) creates an MN1-TEL fusion gene leading to acute myeloid leukemia. The fusion partner TEL (ETV6) is a member of the ETS family of transcription…”
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Dido3-dependent HDAC6 targeting controls cilium size by de Diego, Ainhoa Sánchez, Alonso Guerrero, Astrid, Martínez-A, Carlos, van Wely, Karel H. M.

“…Primary cilia are involved in a variety of physiological processes such as sensing of the environment, cell growth and development. Numerous developmental…”
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A Unique pH-Dependent Recognition of Methylated Histone H3K4 by PPS and DIDO by Tencer, Adam H., Gatchalian, Jovylyn, Klein, Brianna J., Khan, Abid, Zhang, Yi, Strahl, Brian D., van Wely, Karel H.M., Kutateladze, Tatiana G.

“…The protein partner of Sans-fille (PPS) and its human homolog DIDO mediate diverse chromatin activities, including the regulation of stemness genes in…”
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Interplay between splicing and transcriptional pausing exerts genome-wide control over alternative polyadenylation by Mora Gallardo, Carmen, Sánchez de Diego, Ainhoa, Martínez-A, Carlos, van Wely, Karel H.M.

“…Recent studies have identified multiple polyadenylation sites in nearly all mammalian genes. Although these are interpreted as evidence for alternative…”
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Chromothripsis: Breakage-fusion-bridge over and over again by Oscar Sánchez Solorzano, Carlos, Pascual-Montano, Alberto, Sánchez de Diego, Ainhoa, Martínez-A, Carlos, H.M. van Wely, Karel

“…The acquisition of massive but localized chromosome translocations, a phenomenon termed chromothripsis, has received widespread attention since its discovery…”
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