Search Results - "van Weerden, Wytske"

Extensive preclinical evaluation of lutetium-177-labeled PSMA-specific tracers for prostate cancer radionuclide therapy by Ruigrok, Eline A. M., van Vliet, Nicole, Dalm, Simone U., de Blois, Erik, van Gent, Dik C., Haeck, Joost, de Ridder, Corrina, Stuurman, Debra, Konijnenberg, Mark W., van Weerden, Wytske M., de Jong, Marion, Nonnekens, Julie

“…Purpose Various radiolabeled prostate-specific membrane antigen (PSMA)–targeting tracers are clinically applied for prostate cancer (PCa) imaging and targeted…”
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Role of the DNA damage response in prostate cancer formation, progression and treatment by Zhang, Wenhao, van Gent, Dik C., Incrocci, Luca, van Weerden, Wytske M., Nonnekens, Julie

“…Background Clinical and preclinical studies have revealed that alterations in DNA damage response (DDR) pathways may play an important role in prostate cancer…”
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Preclinical Assessment of the Combination of PSMA-Targeting Radionuclide Therapy with PARP Inhibitors for Prostate Cancer Treatment by Ruigrok, Eline, Verkaik, Nicole, de Blois, Erik, de Ridder, Corrina, Stuurman, Debra, Roobol, Stefan, Van Gent, Dik, de Jong, Marion, Van Weerden, Wytske, Nonnekens, Julie

“…Prostate specific membrane antigen targeted radionuclide therapy (PSMA-TRT) is a promising novel treatment for prostate cancer (PCa) patients. However,…”
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Androgen receptor signalling impairs docetaxel efficacy in castration-resistant prostate cancer by Mout, Lisanne, Moll, Jan M., Chen, Mingqing, de Morrée, Eleonora S., de Ridder, Corrina M. A., Gibson, Alice, Stuurman, Debra, Aghai, Ashraf, Erkens-Schulze, Sigrun, Mathijssen, Ron H. J., Sparreboom, Alex, de Wit, Ronald, Lolkema, Martijn P., van Weerden, Wytske M.

“…Androgen receptor (AR) signalling drives neoplastic growth and therapy resistance in prostate cancer. Recent clinical data show that docetaxel combined with…”
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Efficacy of Cabazitaxel in Castration-resistant Prostate Cancer Is Independent of the Presence of AR-V7 in Circulating Tumor Cells by Onstenk, Wendy, Sieuwerts, Anieta M, Kraan, Jaco, Van, Mai, Nieuweboer, Annemieke J.M, Mathijssen, Ron H.J, Hamberg, Paul, Meulenbeld, Hielke J, De Laere, Bram, Dirix, Luc Y, van Soest, Robert J, Lolkema, Martijn P, Martens, John W.M, van Weerden, Wytske M, Jenster, Guido W, Foekens, John A, de Wit, Ronald, Sleijfer, Stefan

“…Abstract Background Androgen receptor splice variant 7 ( AR-V7 ) in circulating tumor cells (CTCs) from patients with metastatic castration-resistant prostate…”
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Bypass mechanisms of the androgen receptor pathway in therapy-resistant prostate cancer cell models by Marques, Rute B, Dits, Natasja F, Erkens-Schulze, Sigrun, van Weerden, Wytske M, Jenster, Guido

“…Prostate cancer is initially dependent on androgens for survival and growth, making hormonal therapy the cornerstone treatment for late-stage tumors. However,…”
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Apalutamide Sensitizes Prostate Cancer to Ionizing Radiation via Inhibition of Non-Homologous End-Joining DNA Repair by Zhang, Wenhao, Liao, Chen-Yi, Chtatou, Hajar, Incrocci, Luca, van Gent, Dik, van Weerden, Wytske, Nonnekens, Julie

“…Androgen-deprivation therapy was shown to improve treatment outcome of external beam radiation therapy (EBRT) for locally advanced prostate cancer (PCa). DNA…”
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The Future of PSMA-Targeted Radionuclide Therapy: An Overview of Recent Preclinical Research by Ruigrok, Eline A M, van Weerden, Wytske M, Nonnekens, Julie, de Jong, Marion

“…Prostate specific membrane antigen (PSMA) has become a major focus point in the research and development of prostate cancer (PCa) imaging and therapeutic…”
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Hybrid Tracers Based on Cyanine Backbones Targeting Prostate-Specific Membrane Antigen: Tuning Pharmacokinetic Properties and Exploring Dye-Protein Interaction by Hensbergen, Albertus W, Buckle, Tessa, van Willigen, Danny M, Schottelius, Margret, Welling, Mick M, van der Wijk, Felicia A, Maurer, Tobias, van der Poel, Henk G, van der Pluijm, Gabri, van Weerden, Wytske M, Wester, Hans-Jürgen, van Leeuwen, Fijs W B

“…Prostate cancer surgery is currently being revolutionized by the use of prostate-specific membrane antigen (PSMA)-targeted radiotracers, for example,…”
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Movember GAP1 PDX project: An international collection of serially transplantable prostate cancer patient‐derived xenograft (PDX) models by Navone, Nora M., van Weerden, Wytske M., Vessella, Robert L., Williams, Elizabeth D., Wang, Yuzhuo, Isaacs, John T., Nguyen, Holly M., Culig, Zoran, van der Pluijm, Gabri, Rentsch, Cyril A., Marques, Rute B., de Ridder, Corrina M. A., Bubendorf, Lukas, Thalmann, George N., Brennen, William Nathaniel, Santer, Frédéric R., Moser, Patrizia L., Shepherd, Peter, Efstathiou, Eleni, Xue, Hui, Lin, Dong, Buijs, Jeroen, Bosse, Tjalling, Collins, Anne, Maitland, Norman, Buzza, Mark, Kouspou, Michelle, Achtman, Ariel, Taylor, Renea A., Risbridger, Gail, Corey, Eva

“…Background While it has been challenging to establish prostate cancer patient‐derived xenografts (PDXs), with a take rate of 10‐40% and long latency time,…”
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Characterization of Heterogeneous Prostate Tumors in Targeted Pten Knockout Mice by Korsten, Hanneke, Ziel-van der Made, Angelique C J, van Weerden, Wytske M, van der Kwast, Theo, Trapman, Jan, Van Duijn, Petra W

“…Previously, we generated a preclinical mouse prostate tumor model based on PSA-Cre driven inactivation of Pten. In this model homogeneous hyperplastic…”
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In Vivo Stabilization of a Gastrin-Releasing Peptide Receptor Antagonist Enhances PET Imaging and Radionuclide Therapy of Prostate Cancer in Preclinical Studies by Chatalic, Kristell L S, Konijnenberg, Mark, Nonnekens, Julie, de Blois, Erik, Hoeben, Sander, de Ridder, Corrina, Brunel, Luc, Fehrentz, Jean-Alain, Martinez, Jean, van Gent, Dik C, Nock, Berthold A, Maina, Theodosia, van Weerden, Wytske M, de Jong, Marion

“…A single tool for early detection, accurate staging, and personalized treatment of prostate cancer (PCa) would be a major breakthrough in the field of PCa…”
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Modulation of androgen receptor signaling in hormonal therapy-resistant prostate cancer cell lines by Marques, Rute B, Dits, Natasja F, Erkens-Schulze, Sigrun, van Ijcken, Wilfred F J, van Weerden, Wytske M, Jenster, Guido

“…Prostate epithelial cells depend on androgens for survival and function. In (early) prostate cancer (PCa) androgens also regulate tumor growth, which is…”
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Correction to: Role of the DNA damage response in prostate cancer formation, progression and treatment by Zhang, Wenhao, van Gent, Dik C., Incrocci, Luca, van Weerden, Wytske M., Nonnekens, Julie

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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TMPRSS2:ERG fusion by translocation or interstitial deletion is highly relevant in androgen-dependent prostate cancer, but is bypassed in late-stage androgen receptor-negative prostate cancer by HERMANS, Karin G, VAN MARION, Ronald, VAN DEKKEN, Herman, JENSTER, Guido, VAN WEERDEN, Wytske M, TRAPMAN, Jan

“…Recently, a unique fusion between the prostate-specific, androgen-regulated TMPRSS2 gene and the ETS genes ERG, ETV1, or ETV4 has been described in clinical…”
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Loss of SLCO1B3 drives taxane resistance in prostate cancer by de Morrée, Ellen S, Böttcher, René, van Soest, Robert J, Aghai, Ashraf, de Ridder, Corrina M, Gibson, Alice A, Mathijssen, Ron HJ, Burger, Herman, Wiemer, Erik AC, Sparreboom, Alex, de Wit, Ronald, van Weerden, Wytske M

“…Background: Both taxanes, docetaxel and cabazitaxel, are effective treatments for metastatic castration-resistant prostate cancer (mCRPC). However, resistance…”
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Evidence of Limited Contributions for Intratumoral Steroidogenesis in Prostate Cancer by HOFLAND, Johannes, VAN WEERDEN, Wytske M, DITS, Natasja F. J, STEENBERGEN, Jacobie, VAN LEENDERS, Geert J. L. H, JENSTER, Guido, SCHRÖDER, Fritz H, DE JONG, Frank H

“…Androgen-deprivation therapy for prostate cancer (PC) eventually leads to castration-resistant PC (CRPC). Intratumoral androgen production might contribute to…”
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GRPR versus PSMA: expression profiles during prostate cancer progression demonstrate the added value of GRPR-targeting theranostic approaches by Verhoeven, Marjolein, Ruigrok, Eline A. M., van Leenders, Geert J. L. H., van den Brink, Lilian, Balcioglu, Hayri E., van Weerden, Wytske M., Dalm, Simone U.

“…Introduction Central to targeted radionuclide imaging and therapy of prostate cancer (PCa) are prostate-specific membrane antigen (PSMA)-targeting…”
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Continued androgen signalling inhibition improves cabazitaxel efficacy in prostate cancer by Mout, Lisanne, van Royen, Martin E., de Ridder, Corrina, Stuurman, Debra, van de Geer, Wesley S., Marques, Rute, Buck, Stefan A.J., French, Pim J., van de Werken, Harmen J.G., Mathijssen, Ron H.J., de Wit, Ronald, Lolkema, Martijn P., van Weerden, Wytske M.

“…: The androgen receptor (AR) pathway is a key driver of neoplastic behaviour in the different stages of metastatic prostate cancer (mPCa). Targeting the AR…”
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NanoBiT System and Hydrofurimazine for Optimized Detection of Viral Infection in Mice-A Novel in Vivo Imaging Platform by Gaspar, Natasa, Zambito, Giorgia, Dautzenberg, Iris J C, Cramer, Steve J, Hoeben, Rob C, Lowik, Clemens, Walker, Joel R, Kirkland, Thomas A, Smith, Thomas P, van Weerden, Wytske M, de Vrij, Jeroen, Mezzanotte, Laura

“…Reporter genes are used to visualize intracellular biological phenomena, including viral infection. Here we demonstrate bioluminescent imaging of viral…”
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