Search Results - "van Vlijmen, Bart J.M"

Induction of atherosclerotic plaque rupture in apolipoprotein E-/- mice after adenovirus-mediated transfer of p53 by VON DER THÜSEN, Jan H, VAN VLIJMEN, Bart J. M, HOEBEN, Rob C, KOCKX, Mark M, HAVEKES, Louis M, VAN BERKEL, Theo J. C, BIESSEN, Erik A. L

“…The presence of the tumor-suppressor gene p53 in advanced atherosclerotic plaques and the sensitivity to p53-induced cell death of smooth muscle cells isolated…”
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The hepatic uptake of VLDL in lrp−ldlr−/−vldlr−/− mice is regulated by LPL activity and involves proteoglycans and SR-BI by Hu, Lihui, van der Hoogt, Caroline C., Espirito Santo, Sonia M.S., Out, Ruud, Kypreos, Kyriakos E., van Vlijmen, Bart J.M., Van Berkel, Theo J.C., Romijn, Johannes A., Havekes, Louis M., van Dijk, Ko Willems, Rensen, Patrick C.N.

“…LPL activity plays an important role in preceding the VLDL remnant clearance via the three major apolipoprotein E (apoE)-recognizing receptors: the LDL…”
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Macrophage p53 controls macrophage death in atherosclerotic lesions of apolipoprotein E deficient mice by Boesten, Lianne S.M, Zadelaar, A. Susanne M, van Nieuwkoop, Anita, Hu, Lihui, Teunisse, Amina F.A.S, Jochemsen, Aart G, Evers, Bastiaan, van de Water, Bob, Gijbels, Marion J.J, van Vlijmen, Bart J.M, Havekes, Louis M, de Winther, Menno P.J

“…Abstract The cellular composition of atherosclerotic lesions is determined by many factors including cell infiltration, proliferation and cell death. Tumor…”
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Macrophage p53 Deficiency Leads to Enhanced Atherosclerosis in APOE3-Leiden Transgenic Mice by van Vlijmen, Bart J.M, Gerritsen, Gery, Franken, Arthur L, Boesten, Lianne S.M, Kockx, Mark M, Gijbels, Marion J, Vierboom, Michel P, van Eck, Miranda, van deWater, Bob, van Berkel, Theo J.C, Havekes, Louis M

“…ABSTRACT—Cell proliferation and cell death (either necrosis or apoptosis) are key processes in the progression of atherosclerosis. The tumor suppressor gene…”
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Obesity promotes injury induced femoral artery thrombosis in mice by Nagai, Nobuo, Hoylaerts, Marc F, Cleuren, Audrey C.A, Van Vlijmen, Bart J.M, Lijnen, H. Roger

“…Abstract An FeCl3 induced femoral arterial thrombosis model was applied to lean (47 ± 1.4 g) and obese (64 ± 1.7 g) mice (Swiss genetic background) in order to…”
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P-Glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain and Blood Disposition of the mTOR Inhibitor Everolimus (Afinitor) in Mice by SENG CHUAN TANG, SPARIDANS, Rolf W, KA LEI CHEUNG, FUKAMI, Tatsuki, DURMUS, Selvi, WAGENAAR, Els, YOKOI, Tsuyoshi, VAN VLIJMEN, Bart J. M, BEIJNEN, Jos H, SCHINKEL, Alfred H

“…To clarify the role of ABCB1, ABCG2, and CYP3A in blood and brain exposure of everolimus using knockout mouse models. We used wild-type, Abcb1a/1b(-/-),…”
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Circulating nucleosomes and elastase α1-antitrypsin complexes and the novel thrombosis susceptibility locus SLC44A2 by Heestermans, Marco, Cunha, Marisa L.R, Reitsma, Pieter H, Zeerleder, Sacha S, Middeldorp, Saskia, van Vlijmen, Bart J.M

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Quantitative Assessment of Aortic Atherosclerosis in APOE3 Leiden Transgenic Mice and Its Relationship to Serum Cholesterol Exposure by Groot, Pieter H.E, van Vlijmen, Bart J.M, Benson, G. Martin, Hofker, Marten H, Schiffelers, Raymond, Vidgeon-Hart, Martin, Havekes, Louis M

“…Transgenic mice overexpressing the human dysfunctional apolipoprotein E variant, APOE*3 Leiden, develop hyperlipidemia and are highly susceptible to…”
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Novel biomarkers to detect occult cancer in patients with unprovoked venous thromboembolism: Rationale and design of the PLATO-VTE study by Kraaijpoel, Noémie, Mulder, Frits I., Carrier, Marc, van Lieshout, Annabel, Würdinger, Tom, Best, Myron G., van Vlijmen, Bart J.M., Mohammed, Yassene, Jara-Palomares, Luis, Kamphuisen, Pieter W., Di Nisio, Marcello, Ageno, Walter, Beyer-Westendorf, Jan, Vanassche, Thomas, Klokm, Frederikus A., Otten, Hans-Martin, Peters, Mike J.L., Cosmi, Benilde, Wolde, Marije ten, Bossuyt, Patrick M.M., Büller, Harry R., van Es, Nick

“…Occult cancer is detected in about 5% of patients with unprovoked venous thromboembolism (VTE) in the 12 months following VTE diagnosis. Current guidance…”
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The hepatic uptake of VLDL in lrpldlrvldlr mice is regulated by LPL activity and involves proteoglycans and SR-BI by Hu, Lihui, van der Hoogt, Caroline C., Espirito Santo, Sonia M.S., Out, Ruud, Kypreos, Kyriakos E., van Vlijmen, Bart J.M., Van Berkel, Theo J.C., Romijn, Johannes A., Havekes, Louis M., van Dijk, Ko Willems, Rensen, Patrick C.N.

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Dual PPARα/γ Agonist Tesaglitazar Reduces Atherosclerosis in Insulin-Resistant and Hypercholesterolemic ApoE3Leiden Mice by Zadelaar, A Susanne M, Boesten, Lianne S.M, Jukema, J Wouter, van Vlijmen, Bart J.M, Kooistra, Teake, Emeis, Jef J, Lundholm, Erik, Camejo, German, Havekes, Louis M

“…OBJECTIVE—We investigated whether the dual PPARα/γ agonist tesaglitazar has anti-atherogenic effects in ApoE*3Leiden mice with reduced insulin sensitivity…”
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Genetic inflammatory factors predict restenosis after percutaneous coronary interventions by MONRAATS, Pascalle S, PIRES, Nuno M. M, FRANTS, Rune R, QUAX, Paul H. A, VAN VLIJMEN, Bart J. M, ATSMA, Douwe E, VAN DER LAARSE, Arnoud, VAN DER WALL, Ernst E, JUKEMA, J. Wouter, AGEMA, Willem R. P, ZWINDERMAN, Aeiiko H, SCHEPERS, Abbey, DE MAAT, Moniek P. M, DOEVENDANS, Pieter A, DE WINTER, Robbert J, TIO, René A, WALTENBERGER, Johannes

“…Restenosis is a negative effect of percutaneous coronary intervention (PCI). No clinical factors are available that allow good risk stratification. However,…”
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The VLDL receptor plays a major role in chylomicron metabolism by enhancing LPL-mediated triglyceride hydrolysis by Goudriaan, Jeltje R., Santo, Sonia M. S. Espirito, Voshol, Peter J., Teusink, Bas, van Dijk, Ko Willems, van Vlijmen, Bart J.M., Romijn, Johannes A., Havekes, Louis M., Rensen, Patrick C.N.

“…The VLDL receptor (VLDLr) is involved in tissue delivery of VLDL-triglyceride (TG)-derived FFA by facilitating the expression of lipoprotein lipase (LPL)…”
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Progestins posses poor anti-estrogenic activity on murine hepatic coagulation gene transcription despite evident anti-estrogenic activity on uterine tissue by Cleuren, Audrey C.A, Postmus, Iris, Vos, Hans L, Reitsma, Pieter H, van Vlijmen, Bart J.M

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Triglyceride-rich lipoprotein metabolism in unique VLDL receptor, LDL receptor, and LRP triple-deficient mice by Santo, Sonia M. S. Espirito, Rensen, Patrick C. N, Goudriaan, Jeltje R, Bensadoun, André, Bovenschen, Niels, Voshol, Peter J, Havekes, Louis M, van Vlijmen, Bart J. M

“…The very low density lipoprotein receptor (VLDLR), low density lipoprotein receptor (LDLR), and low density lipoprotein receptor-related protein (LRP) are the…”
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Macrophage retinoblastoma deficiency leads to enhanced atherosclerosis development in ApoE-deficient mice by Boesten, Lianne S.M, Zadelaar, A. Susanne M, Nieuwkoop, Anita van, Hu, Lihui, Jonkers, Jos, Water, Bob van de, Gijbels, Marion J.J, Made, Ingeborg van der, Winther, Menno P.J. de, Havekes, Louis M, Vlijmen, Bart J.M. van

“…The cellular composition of an atherosclerotic lesion is determined by cell infiltration, proliferation, and apoptosis. The tumor suppressor gene…”
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Transgenic mouse models to study the role of APOE in hyperlipidemia and atherosclerosis by Hofker, Marten H, van Vlijmen, Bart J.M, Havekes, Louis M

“…Transgenic technologies have provided a series of very useful mouse models to study hyperlipidemia and atherosclerosis. Normally, mice carry cholesterol mainly…”
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extrahepatic receptor-associated protein-sensitive mechanism is involved in the metabolism of triglyceride-rich lipoproteins by Vlijmen, B.J.M. van, Rohlmann, A, Page, S.T, Bensadoun, A, Bos, I.S.T, BErkel, T.J.C. van, Havekes, L.M, Herz, J

“…We have used adenovirus-mediated gene transfer in mice to investigate low density lipoprotein receptor (LDLR) and LDLR-related protein (LRP)-independent…”
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Impaired adhesion of neutrophils expressing Slc44a2/HNA-3b to VWF protects against NETosis under venous shear rates by Zirka, Gaïa, Robert, Philippe, Tilburg, Julia, Tishkova, Victoria, Maracle, Chrissta X., Legendre, Paulette, van Vlijmen, Bart J.M., Alessi, Marie-Christine, Lenting, Peter J., Morange, Pierre-Emmanuel, Thomas, Grace M.

“…Genome-wide association studies linked expression of the human neutrophil antigen 3b (HNA-3b) epitope on the Slc44a2 protein with a 30% decreased risk of…”
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The effects of an aggressive breast tumor on thrombosis after antithrombin downregulation in a hypercoagulable mouse model by Ünlü, Betül, Heestermans, Marco, Laghmani, El Houari, Buijs, Jeroen T., van den Akker, Rob F.P., van Vlijmen, Bart J.M., Versteeg, Henri H.

“…Despite improvements in therapy, breast cancer still contributes to high mortality rates. Survival of these patients becomes progressively worse upon diagnosis…”
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