Search Results - "van Vliet, Erwin A."

Expression and Cellular Distribution of P-Glycoprotein and Breast Cancer Resistance Protein in Amyotrophic Lateral Sclerosis Patients by van Vliet, Erwin A, Iyer, Anand M, Mesarosova, Lucia, Çolakoglu, Hilal, Anink, Jasper J, van Tellingen, Olaf, Maragakis, Nicholas J, Shefner, Jeremy, Bunt, Ton, Aronica, Eleonora

“…Abstract For amyotrophic lateral sclerosis (ALS), achieving and maintaining effective drug levels in the brain is challenging due to the activity of…”
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Glycine transporter 1 is a target for the treatment of epilepsy by Shen, Hai-Ying, van Vliet, Erwin A., Bright, Kerry-Ann, Hanthorn, Marissa, Lytle, Nikki K., Gorter, Jan, Aronica, Eleonora, Boison, Detlev

“…Glycine is the major inhibitory neurotransmitter in brainstem and spinal cord, whereas in hippocampus glycine exerts dual modulatory roles on…”
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Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury by van Vliet, Erwin A., Ndode-Ekane, Xavier Ekolle, Lehto, Lauri J., Gorter, Jan A., Andrade, Pedro, Aronica, Eleonora, Gröhn, Olli, Pitkänen, Asla

“…Traumatic brain injury (TBI) causes 10–20% of acquired epilepsy, which typically develops within 2 years post-injury with poorly understood mechanisms. We…”
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Status epilepticus, blood–brain barrier disruption, inflammation, and epileptogenesis by Gorter, Jan A, van Vliet, Erwin A, Aronica, Eleonora

“…Abstract Over the last 15 years, attention has been focused on dysfunction of the cerebral vasculature and inflammation as important players in epileptogenic…”
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Inhibition of the Multidrug Transporter P‐Glycoprotein Improves Seizure Control in Phenytoin‐treated Chronic Epileptic Rats by Van Vliet, Erwin A., Van Schaik, Rosalinde, Edelbroek, Peter M., Redeker, Sandra, Aronica, Eleonora, Wadman, Wytse J., Marchi, Nicola, Vezzani, Annamaria, Gorter, Jan A.

“…Purpose: Overexpression of multidrug transporters such as P‐glycoprotein (P‐gp) may play a significant role in pharmacoresistance, by preventing antiepileptic…”
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Astrocytes as Guardians of Neuronal Excitability: Mechanisms Underlying Epileptogenesis by Verhoog, Quirijn P, Holtman, Linda, Aronica, Eleonora, van Vliet, Erwin A

“…Astrocytes are key homeostatic regulators in the central nervous system and play important roles in physiology. After brain damage caused by e.g., status…”
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A novel GABAergic dysfunction in human Dravet syndrome by Ruffolo, Gabriele, Cifelli, Pierangelo, Roseti, Cristina, Thom, Maria, van Vliet, Erwin A., Limatola, Cristina, Aronica, Eleonora, Palma, Eleonora

“…Summary Objective Dravet syndrome is a rare neurodevelopmental disease, characterized by general cognitive impairment and severe refractory seizures. The…”
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GABAA currents are decreased by IL-1β in epileptogenic tissue of patients with temporal lobe epilepsy: implications for ictogenesis by Roseti, Cristina, van Vliet, Erwin A, Cifelli, Pierangelo, Ruffolo, Gabriele, Baayen, Johannes C, Di Castro, Maria Amalia, Bertollini, Cristina, Limatola, Cristina, Aronica, Eleonora, Vezzani, Annamaria, Palma, Eleonora

“…Abstract Temporal lobe epilepsy (TLE) is the most prevalent form of adult focal onset epilepsy often associated with drug-resistant seizures. Numerous studies…”
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Localization of Breast Cancer Resistance Protein (BCRP) in Microvessel Endothelium of Human Control and Epileptic Brain by Aronica, Eleonora, Gorter, Jan A., Redeker, Sandra, Van Vliet, Erwin A., Ramkema, Marja, Scheffer, George L., Scheper, Rik J., Van Der Valk, Paul, Leenstra, Sieger, Baayen, Johannes C., Spliet, Wim G. M., Troost, Dirk

“…Purpose: Breast cancer resistance protein (BCRP) is a half adenosine triphosphate (ATP)‐binding cassette (ABC) transporter expressed on cellular membranes and…”
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Expression of Multidrug Transporters MRP1, MRP2, and BCRP Shortly after Status Epilepticus, during the Latent Period, and in Chronic Epileptic Rats by Van Vliet, Erwin A., Redeker, Sandra, Aronica, Eleonora, Edelbroek, Peter M., Gorter, Jan A.

“…Purpose: Overexpression of multidrug transporters may play a role in the development of pharmacoresistance by decreasing extracellular drug levels in the…”
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Hippocampal subregion-specific microRNA expression during epileptogenesis in experimental temporal lobe epilepsy by Gorter, Jan A, Iyer, Anand, White, Ian, Colzi, Anna, van Vliet, Erwin A, Sisodiya, Sanjay, Aronica, Eleonora

“…Abstract Since aberrant miRNA expression has been implicated in numerous brain diseases, we studied miRNA expression and miRNA regulation of important…”
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n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis by Frigerio, Federica, Pasqualini, Giulia, Craparotta, Ilaria, Marchini, Sergio, van Vliet, Erwin A, Foerch, Patrick, Vandenplas, Catherine, Leclercq, Karin, Aronica, Eleonora, Porcu, Luca, Pistorius, Kimberly, Colas, Romain A, Hansen, Trond V, Perretti, Mauro, Kaminski, Rafal M, Dalli, Jesmond, Vezzani, Annamaria

“…Frigerio et al. report that pro-resolving mechanisms of neuroinflammation are dysregulated during epileptogenesis, thereby promoting a persistent…”
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Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation by van Vliet, Erwin A., Forte, Grazia, Holtman, Linda, den Burger, Jeroen C. G., Sinjewel, Arno, de Vries, Helga E., Aronica, Eleonora, Gorter, Jan A.

“…Summary Purpose:  Previous studies have shown that inhibition of the mammalian target of rapamycin (mTOR) pathway with rapamycin prevents epileptogenesis after…”
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Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy by Zimmer, Till S., David, Bastian, Broekaart, Diede W. M., Schidlowski, Martin, Ruffolo, Gabriele, Korotkov, Anatoly, van der Wel, Nicole N., van Rijen, Peter C., Mühlebner, Angelika, van Hecke, Wim, Baayen, Johannes C., Idema, Sander, François, Liesbeth, van Eyll, Jonathan, Dedeurwaerdere, Stefanie, Kessels, Helmut W., Surges, Rainer, Rüber, Theodor, Gorter, Jan A., Mills, James D., van Vliet, Erwin A., Aronica, Eleonora

“…Neuronal dysfunction due to iron accumulation in conjunction with reactive oxygen species (ROS) could represent an important, yet underappreciated, component…”
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Standardization procedure for plasma biomarker analysis in rat models of epileptogenesis: Focus on circulating microRNAs by Vliet, Erwin A., Puhakka, Noora, Mills, James D., Srivastava, Prashant K., Johnson, Michael R., Roncon, Paolo, Das Gupta, Shalini, Karttunen, Jenni, Simonato, Michele, Lukasiuk, Katarzyna, Gorter, Jan A., Aronica, Eleonora, Pitkänen, Asla

“…Summary The World Health Organization estimates that globally 2.4 million people are diagnosed with epilepsy each year. In nearly 30% of these cases, epilepsy…”
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Discovery and Validation of Circulating microRNAs as Biomarkers for Epileptogenesis after Experimental Traumatic Brain Injury-The EPITARGET Cohort by Heiskanen, Mette, Das Gupta, Shalini, Mills, James D, van Vliet, Erwin A, Manninen, Eppu, Ciszek, Robert, Andrade, Pedro, Puhakka, Noora, Aronica, Eleonora, Pitkänen, Asla

“…Traumatic brain injury (TBI) causes 10-20% of structural epilepsies and 5% of all epilepsies. The lack of prognostic biomarkers for post-traumatic epilepsy…”
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Coding and non-coding transcriptome of mesial temporal lobe epilepsy: Critical role of small non-coding RNAs by Mills, James D., van Vliet, Erwin A., Chen, Bei Jun, Janitz, Michael, Anink, Jasper J., Baayen, Johannes C., Idema, Sander, Devore, Sasha, Friedman, Daniel, Diehl, Beate, Thom, Maria, Scott, Catherine, Thijs, Roland, Aronica, Eleonora, Devinsky, Orrin

“…Our understanding of mesial temporal lobe epilepsy (MTLE), one of the most common form of drug-resistant epilepsy in humans, is derived mainly from clinical,…”
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Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation by Korotkov, Anatoly, Puhakka, Noora, Gupta, Shalini Das, Vuokila, Niina, Broekaart, Diede W. M., Anink, Jasper J., Heiskanen, Mette, Karttunen, Jenni, Scheppingen, Jackelien, Huitinga, Inge, Mills, James D., Vliet, Erwin A., Pitkänen, Asla, Aronica, Eleonora

“…Traumatic brain injury (TBI) is associated with the pathological activation of immune‐competent cells in the brain, such as astrocytes, microglia and…”
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Neuronal Cell Death in a Rat Model for Mesial Temporal Lobe Epilepsy Is Induced by the Initial Status Epilepticus and Not by Later Repeated Spontaneous Seizures by Gorter, Jan A., Pereira, Pedro M. Gonçalves, Van Vliet, Erwin A., Aronica, Eleonora, Da Silva, Fernando H. Lopes, Lucassen, Paul J.

“…Purpose: To determine whether repeated seizures contribute to hippocampal sclerosis, we investigated whether cell loss in the (para) hippocampal region was…”
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Which insights have we gained from the kindling and post-status epilepticus models? by Gorter, Jan A., van Vliet, Erwin A., Lopes da Silva, Fernando H.

“…•Kindling is associated with mild neuropathological and molecular changes.•Spontaneous temporal lobe seizures occur only after overkindling.•The kindling model…”
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