Search Results - "van Vliet, E. A."

Effects of rapamycin and curcumin on inflammation and oxidative stress in vitro and in vivo - in search of potential anti-epileptogenic strategies for temporal lobe epilepsy by Drion, C M, van Scheppingen, J, Arena, A, Geijtenbeek, K W, Kooijman, L, van Vliet, E A, Aronica, E, Gorter, J A

“…Previous studies in various rodent epilepsy models have suggested that mammalian target of rapamycin (mTOR) inhibition with rapamycin has anti-epileptogenic…”
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Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy by Aronica, E., Fluiter, K., Iyer, A., Zurolo, E., Vreijling, J., Van Vliet, E. A., Baayen, J. C., Gorter, J. A.

“…Increasing evidence supports the involvement of inflammatory and immune processes in temporal lobe epilepsy (TLE). MicroRNAs (miRNA) represent small regulatory…”
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Blood–brain barrier leakage may lead to progression of temporal lobe epilepsy by van Vliet, E. A., da Costa Araújo, S., Redeker, S., van Schaik, R., Aronica, E., Gorter, J. A.

“…Leakage of the blood–brain barrier (BBB) is associated with various neurological disorders, including temporal lobe epilepsy (TLE). However, it is not known…”
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Review: Neuroinflammatory pathways as treatment targets and biomarker candidates in epilepsy: emerging evidence from preclinical and clinical studies by Vliet, E. A., Aronica, E., Vezzani, A., Ravizza, T.

“…Accumulating evidence indicates an important pathophysiological role of brain inflammation in epilepsy. In this review, we will provide an update of specific…”
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Flipped-Class Pedagogy Enhances Student Metacognition and Collaborative-Learning Strategies in Higher Education but Effect Does Not Persist by van Vliet, E. A, Winnips, J. C, Brouwer, N

“…In flipped-class pedagogy, students prepare themselves at home before lectures, often by watching short video clips of the course contents. The aim of this…”
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Systematic review and meta-analysis of differentially expressed miRNAs in experimental and human temporal lobe epilepsy by Korotkov, A., Mills, J. D., Gorter, J. A., van Vliet, E. A., Aronica, E.

“…Temporal lobe epilepsy (TLE) is a common chronic neurological disease in humans. A number of studies have demonstrated differential expression of miRNAs in the…”
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Role of blood–brain barrier in temporal lobe epilepsy and pharmacoresistance by van Vliet, E.A, Aronica, E, Gorter, J.A

“…Highlights • Blood–brain barrier changes in epileptogenic brain tissue. • Role of BBB in the development and progression of epilepsy. • Role of BBB in the…”
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Complement protein 6 deficiency in PVG/c rats does not lead to neuroprotection against seizure induced cell death by Holtman, L, van Vliet, E.A, Baas, F, Aronica, E, Gorter, J.A

“…Abstract Since the membrane attack complex (MAC), an end product of the activated complement cascade, has been shown to play a role in neurodegeneration, we…”
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The Roof is Leaking and a Storm is Raging: Repairing the Blood–Brain Barrier in the Fight Against Epilepsy by Gorter, J.A., Aronica, E., van Vliet, E.A.

“…A large body of evidence that has accumulated over the past decade strongly supports the role of both blood–brain barrier (BBB) dysfunction and perivascular…”
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Biocompatibility of phosphorylcholine coated stents in normal porcine coronary arteries by Whelan, D M, van der Giessen, W J, Krabbendam, S C, van Vliet, E A, Verdouw, P D, Serruys, P W, van Beusekom, H M M

“…OBJECTIVE To improve the biocompatibility of stents using a phosphorylcholine coated stent as a form of biomimicry. INTERVENTIONS Implantation of…”
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Expression of microRNAs miR21, miR146a, and miR155 in tuberous sclerosis complex cortical tubers and their regulation in human astrocytes and SEGA-derived cell cultures by van Scheppingen, J., Iyer, A. M., Prabowo, A. S., Mühlebner, A., Anink, J. J., Scholl, T., Feucht, M., Jansen, F. E., Spliet, W. G., Krsek, P., Zamecnik, J., Buccoliero, A. M., Giordano, F., Genitori, L., Kotulska, K., Jozwiak, S., Jaworski, J., Liszewska, E., van Vliet, E. A., Aronica, E.

“…Tuberous sclerosis complex (TSC) is a genetic disease presenting with multiple neurological symptoms including epilepsy, mental retardation, and autism…”
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Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy by Holtman, L, van Vliet, E.A, van Schaik, R, Queiroz, C.M, Aronica, E, Gorter, J.A

“…Summary Inflammation is an important biological process that is activated after status epilepticus and could be implicated in the development of epilepsy. Here…”
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Dysregulation of the (immuno)proteasome pathway in malformations of cortical development by van Scheppingen, J, Broekaart, D W M, Scholl, T, Zuidberg, M R J, Anink, J J, Spliet, W G, van Rijen, P C, Czech, T, Hainfellner, J A, Feucht, M, Mühlebner, A, van Vliet, E A, Aronica, E

“…The proteasome is a multisubunit enzyme complex involved in protein degradation, which is essential for many cellular processes. During inflammation, the…”
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Region-specific overexpression of P-glycoprotein at the blood-brain barrier affects brain uptake of phenytoin in epileptic rats by van Vliet, E A, van Schaik, R, Edelbroek, P M, Voskuyl, R A, Redeker, S, Aronica, E, Wadman, W J, Gorter, J A

“…Recent studies have suggested that overexpression of the multidrug transporter P-glycoprotein (P-gp) in the hippocampal region leads to decreased levels of…”
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Blood–brain barrier dysfunction, seizures and epilepsy by van Vliet, E.A., Aronica, E., Gorter, J.A.

“…The blood–brain barrier (BBB) is a dynamic and complex system which separates the brain from the blood. It helps to maintain the homeostasis of the brain,…”
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Progression of spontaneous seizures after status epilepticus is associated with mossy fibre sprouting and extensive bilateral loss of hilar parvalbumin and somatostatin-immunoreactive neurons by Gorter, J. A., Van Vliet, E. A., Aronica, E., Da Silva, F. H. Lopes

“…The development of spontaneous limbic seizures was investigated in a rat model in which electrical tetanic stimulation of the angular bundle was applied for up…”
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Sodium currents in isolated rat CA1 pyramidal and dentate granule neurones in the post-status epilepticus model of epilepsy by Ketelaars, S.O.M, Gorter, J.A, van Vliet, E.A, Lopes da Silva, F.H, Wadman, W.J

“…Status epilepticus (SE) was induced in the rat by long-lasting electrical stimulation of the hippocampus. After a latent period of 1 week, spontaneous seizures…”
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Longitudinal assessment of blood–brain barrier leakage during epileptogenesis in rats. A quantitative MRI study by van Vliet, E.A, Otte, W.M, Gorter, J.A, Dijkhuizen, R.M, Wadman, W.J

“…Abstract The blood–brain barrier (BBB) plays an important role in the homeostasis of the brain. BBB dysfunction has been implicated in the pathophysiology of…”
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Chronic activation of anti‐oxidant pathways and iron accumulation in epileptogenic malformations by Zimmer, T. S., Ciriminna, G., Arena, A., Anink, J. J., Korotkov, A., Jansen, F. E., Hecke, W., Spliet, W. G., Rijen, P. C., Baayen, J. C., Idema, S., Rensing, N. R., Wong, M., Mills, J. D., Vliet, E. A., Aronica, E.

“…Aims Oxidative stress is evident in resected epileptogenic brain tissue of patients with developmental brain malformations related to mammalian target of…”
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Increased matrix metalloproteinases expression in tuberous sclerosis complex: modulation by microRNA 146a and 147b in vitro by Broekaart, D. W. M., Scheppingen, J., Anink, J. J., Wierts, L., Hof, B., Jansen, F. E., Spliet, W. G., van Rijen, P. C., Kamphuis, W. W., de Vries, H. E., Aronica, E., van Vliet, E. A.

“…Aim Matrix metalloproteinases (MMPs) and their endogenous tissue inhibitors (TIMPs) control proteolysis within the extracellular matrix (ECM) of the brain…”
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