Search Results - "van Veen, Toon A.B"

Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG by Jonsson, Malin K.B, Vos, Marc A, Mirams, Gary R, Duker, Göran, Sartipy, Peter, de Boer, Teun P, van Veen, Toon A.B

“…Abstract Human embryonic stem cell-derived cardiomyocytes (hESC-CM) have been proposed as a new model for safety pharmacology. So far, a thorough description…”
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Lessons from the heart: Mirroring electrophysiological characteristics during cardiac development to in vitro differentiation of stem cell derived cardiomyocytes by van den Heuvel, Nikki H.L, van Veen, Toon A.B, Lim, Bing, Jonsson, Malin K.B

“…Abstract The ability of human pluripotent stem cells (hPSCs) to differentiate into any cell type of the three germ layers makes them a very promising cell…”
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Reduced Cx43 Expression Triggers Increased Fibrosis Due to Enhanced Fibroblast Activity by Jansen, John A, van Veen, Toon A.B, de Jong, Sanne, van der Nagel, Roel, van Stuijvenberg, Leonie, Driessen, Helen, Labzowski, Ronald, Oefner, Carolin M, Bosch, Astrid A, Nguyen, Tri Q, Goldschmeding, Roel, Vos, Marc A, de Bakker, Jacques M.T, van Rijen, Harold V.M

“…BACKGROUND—Arrhythmogenic ventricular remodeling is hallmarked by both reduced gap junction expression and increased collagen deposition. We hypothesized that…”
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A Transcriptomic and Epigenomic Comparison of Fetal and Adult Human Cardiac Fibroblasts Reveals Novel Key Transcription Factors in Adult Cardiac Fibroblasts by Jonsson, Malin K.B., PhD, Hartman, Robin J.G., MSc, Ackers-Johnson, Matthew, PhD, Tan, Wilson L.W., BSc, Lim, Bing, MD, PhD, van Veen, Toon A.B., PhD, Foo, Roger S., MD

“…Visual Abstract…”
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Beta-, Not Alpha-Adrenergic Stimulation Enhances Conduction Velocity in Cultures of Neonatal Cardiomyocytes by Boer, Teun P. de, Rijen, Harold V.M. van, Marcel A.G. Van der Heyden, Kok, Bart, Opthof, Tobias, Vos, Marc A., Jongsma, Habo J., Bakker, Jacques M.T. de, Veen, Toon A.B. van

“…Background During both cardiac maturation and myopathy, elevated levels of circulating catecholamines coincide with alterations in impulse propagation. An in…”
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Drug-Induced Torsade de Pointes Arrhythmias in the Chronic AV Block Dog Are Perpetuated by Focal Activity by Boulaksil, Mohamed, Jungschleger, Jerome G, Antoons, Gudrun, Houtman, Marien J.C, de Boer, Teun P, Wilders, Ronald, Beekman, Jet D, Maessen, Jos G, van der Hulst, Ferenc F, van der Heyden, Marcel A.G, van Veen, Toon A.B, van Rijen, Harold V.M, de Bakker, Jacques M.T, Vos, Marc A

“…BACKGROUND—The electrically remodeled canine heart after chronic AV block (CAVB) has a high susceptibility for drug-induced torsade de pointes (TdP)…”
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The immature electrophysiological phenotype of iPSC-CMs still hampers in vitro drug screening: Special focus on I K1 by Goversen, Birgit, van der Heyden, Marcel A G, van Veen, Toon A B, de Boer, Teun P

“…Preclinical drug screens are not based on human physiology, possibly complicating predictions on cardiotoxicity. Drug screening can be humanised with in vitro…”
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Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm by Cerrone, Marina, Montnach, Jerome, Lin, Xianming, Zhao, Yan-Ting, Zhang, Mingliang, Agullo-Pascual, Esperanza, Leo-Macias, Alejandra, Alvarado, Francisco J., Dolgalev, Igor, Karathanos, Thomas V., Malkani, Kabir, Van Opbergen, Chantal J.M., van Bavel, Joanne J.A., Yang, Hua-Qian, Vasquez, Carolina, Tester, David, Fowler, Steven, Liang, Fengxia, Rothenberg, Eli, Heguy, Adriana, Morley, Gregory E., Coetzee, William A., Trayanova, Natalia A., Ackerman, Michael J., van Veen, Toon A.B., Valdivia, Hector H., Delmar, Mario

“…Plakophilin-2 (PKP2) is a component of the desmosome and known for its role in cell–cell adhesion. Mutations in human PKP2 associate with a life-threatening…”
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Human cardiomyocyte progenitor cell-derived cardiomyocytes display a maturated electrical phenotype by de Boer, Teun P, van Veen, Toon A.B, Jonsson, Malin K.B, Kok, Bart G.J.M, Metz, Corina H.G, Sluijter, Joost P.G, Doevendans, Pieter A, de Bakker, Jacques M.T, Goumans, Marie-José, van der Heyden, Marcel A.G

“…Abstract Cardiomyocyte progenitor cells (CMPCs) can be isolated from the human heart and differentiated into cardiomyocytes in vitro . A comprehensive…”
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Triplex protein quantification based on stable isotope labeling by peptide dimethylation applied to cell and tissue lysates by Boersema, Paul J, Aye, Thin Thin, van Veen, Toon A.B, Heck, Albert J.R, Mohammed, Shabaz

“…Stable isotope labeling is at present one of the most powerful methods in quantitative proteomics. Stable isotope labeling has been performed at both the…”
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Required G1 to Suppress Automaticity of iPSC-CMs Depends Strongly on I1 Model Structure by Fabbri, Alan, Goversen, Birgit, Vos, Marc A., van Veen, Toon A.B., de Boer, Teun P.

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Cardiac connexins and impulse propagation by Jansen, John A, van Veen, Toon A.B, de Bakker, Jacques M.T, van Rijen, Harold V.M

“…Abstract Gap junctions form the intercellular pathway for cell-to-cell transmission of the cardiac impulse from its site of origin, the sinoatrial node, along…”
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CTGF knockout does not affect cardiac hypertrophy and fibrosis formation upon chronic pressure overload by Fontes, Magda S.C, Kessler, Elise L, van Stuijvenberg, Leonie, Brans, Maike A, Falke, Lucas L, Kok, Bart, Leask, Andrew, van Rijen, Harold V.M, Vos, Marc A, Goldschmeding, Roel, van Veen, Toon A.B

“…Abstract Background One of the main contributors to maladaptive cardiac remodeling is fibrosis. Connective tissue growth factor (CTGF), a matricellular protein…”
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Plakophilin-2 Haploinsufficiency Causes Calcium Handling Deficits and Modulates the Cardiac Response Towards Stress by van Opbergen, Chantal J M, Noorman, Maartje, Pfenniger, Anna, Copier, Jaël S, Vermij, Sarah H, Li, Zhen, van der Nagel, Roel, Zhang, Mingliang, de Bakker, Jacques M T, Glass, Aaron M, Mohler, Peter J, Taffet, Steven M, Vos, Marc A, van Rijen, Harold V M, Delmar, Mario, van Veen, Toon A B

“…Human variants in plakophilin-2 (PKP2) associate with most cases of familial arrhythmogenic cardiomyopathy (ACM). Recent studies show that PKP2 not only…”
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Defective Cx40 Maintains Cx37 Expression but Intact Cx40 Is Crucial for Conducted Dilations Irrespective of Hypertension by Jobs, Alexander, Schmidt, Kjestine, Schmidt, Volker J, Lübkemeier, Indra, van Veen, Toon A.B, Kurtz, Armin, Willecke, Klaus, de Wit, Cor

“…The gap junction channel protein connexin40 (Cx40) is crucial in vascular and renal physiology, because Cx40-deficient mice exhibit impaired conduction of…”
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Cardiac cell–cell junctions in health and disease: Electrical versus mechanical coupling by Noorman, Maartje, van der Heyden, Marcel A.G, van Veen, Toon A.B, Cox, Moniek G.P.J, Hauer, Richard N.W, de Bakker, Jacques M.T, van Rijen, Harold V.M

“…Abstract Intercalated discs are the membrane sites where individual cardiomyocytes are connected to each other. Adherens-, desmosomal-, and gap junctions are…”
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Optogenetic sensors in the zebrafish heart: a novel in vivo electrophysiological tool to study cardiac arrhythmogenesis by van Opbergen, Chantal J M, Koopman, Charlotte D, Kok, Bart J M, Knöpfel, Thomas, Renninger, Sabine L, Orger, Michael B, Vos, Marc A, van Veen, Toon A B, Bakkers, Jeroen, de Boer, Teun P

“…Cardiac arrhythmias are among the most challenging human disorders to diagnose and treat due to their complex underlying pathophysiology. Suitable experimental…”
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Reorganized PKA-AKAP associations in the failing human heart by Aye, Thin-Thin, Soni, Siddarth, van Veen, Toon A.B, van der Heyden, Marcel A.G, Cappadona, Salvatore, Varro, Andras, de Weger, Roel A, de Jonge, Nicolaas, Vos, Marc A, Heck, Albert J.R, Scholten, Arjen

“…Abstract Here we reveal that the characterization of large-scale re-arrangements of signaling scaffolds induced by heart failure can serve as a novel concept…”
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Anchored protein kinase A signalling in cardiac cellular electrophysiology by Soni, Siddarth, Scholten, Arjen, Vos, Marc A., Veen, Toon A.B.

“…The cyclic adenosine monophosphate (cAMP)‐dependent protein kinase (PKA) is an elementary molecule involved in both acute and chronic modulation of cardiac…”
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Influence of Genotype on Structural Atrial Abnormalities and Atrial Fibrillation or Flutter in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy by BOURFISS, MIMOUNT, TE RIELE, ANNELINE S.J.M., MAST, THOMAS P., CRAMER, MAARTEN J., VAN DER HEIJDEN, JEROEN F., VAN VEEN, TOON A.B., LOH, PETER, DOOIJES, DENNIS, HAUER, RICHARD N.W., VELTHUIS, BIRGITTA K.

“…Structural Atrial Involvement in ARVD/C Introduction Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is associated with desmosomal…”
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