Search Results - "van Veen, Sarah"

Mutated ATP10B increases Parkinson’s disease risk by compromising lysosomal glucosylceramide export by Martin, Shaun, Smolders, Stefanie, Van den Haute, Chris, Heeman, Bavo, van Veen, Sarah, Crosiers, David, Beletchi, Igor, Verstraeten, Aline, Gossye, Helena, Gelders, Géraldine, Pals, Philippe, Hamouda, Norin Nabil, Engelborghs, Sebastiaan, Martin, Jean-Jacques, Eggermont, Jan, De Deyn, Peter Paul, Cras, Patrick, Baekelandt, Veerle, Vangheluwe, Peter, Van Broeckhoven, Christine

“…Parkinson’s disease (PD) is a progressive neurodegenerative brain disease presenting with a variety of motor and non-motor symptoms, loss of midbrain…”
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Clickable Polyamine Derivatives as Chemical Probes for the Polyamine Transport System by Vanhoutte, Roeland, Kahler, Jan Pascal, Martin, Shaun, van Veen, Sarah, Verhelst, Steven H. L.

“…Polyamines are essential for cell growth and differentiation, but their trafficking by the polyamine transport system is not fully understood. Herein, the…”
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ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress by Vrijsen, Stephanie, Besora-Casals, Laura, van Veen, Sarah, Zielich, Jeffrey, Van den Haute, Chris, Hamouda, Norin Nabil, Fischer, Christian, Ghesquière, Bart, Tournev, Ivailo, Agostinis, Patrizia, Baekelandt, Veerle, Eggermont, Jan, Lambie, Eric, Martin, Shaun, Vangheluwe, Peter

“…Recessive loss-of-function mutations in ATP13A2 (PARK9) are associated with a spectrum of neurodegenerative disorders, including Parkinson’s disease (PD). We…”
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A lipid switch unlocks Parkinson’s disease-associated ATP13A2 by Holemans, Tine, Sørensen, Danny Mollerup, van Veen, Sarah, Martin, Shaun, Hermans, Diane, Kemmer, Gerdi Christine, Van den Haute, Chris, Baekelandt, Veerle, Pomorski, Thomas Günther, Agostinis, Patrizia, Wuytack, Frank, Palmgren, Michael, Eggermont, Jan, Vangheluwe, Peter

“…ATP13A2 is a lysosomal P-type transport ATPase that has been implicated in Kufor–Rakeb syndrome and Parkinson’s disease (PD), providing protection against…”
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ATP13A2 Regulates Cellular α-Synuclein Multimerization, Membrane Association, and Externalization by Si, Jianmin, Van den Haute, Chris, Lobbestael, Evy, Martin, Shaun, van Veen, Sarah, Vangheluwe, Peter, Baekelandt, Veerle

“…ATP13A2, a late endo-/lysosomal polyamine transporter, is implicated in a variety of neurodegenerative diseases, including Parkinson's disease and Kufor-Rakeb…”
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Parkinson disease related ATP13A2 evolved early in animal evolution by Sørensen, Danny Mollerup, Holemans, Tine, van Veen, Sarah, Martin, Shaun, Arslan, Tugce, Haagendahl, Ida Winther, Holen, Henrik Waldal, Hamouda, Norin Nabil, Eggermont, Jan, Palmgren, Michael, Vangheluwe, Peter

“…Several human P5-type transport ATPases are implicated in neurological disorders, but little is known about their physiological function and properties. Here,…”
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ATP13A4 Upregulation Drives the Elevated Polyamine Transport System in the Breast Cancer Cell Line MCF7 by van Veen, Sarah, Kourti, Antria, Ausloos, Elke, Van Asselberghs, Joris, Van den Haute, Chris, Baekelandt, Veerle, Eggermont, Jan, Vangheluwe, Peter

“…Polyamine homeostasis is disturbed in several human diseases, including cancer, which is hallmarked by increased intracellular polyamine levels and an…”
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Cellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disorders by van Veen, Sarah, Sørensen, Danny M, Holemans, Tine, Holen, Henrik W, Palmgren, Michael G, Vangheluwe, Peter

“…Mutations in ATP13A2 lead to Kufor-Rakeb syndrome, a parkinsonism with dementia. ATP13A2 belongs to the P-type transport ATPases, a large family of primary…”
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Protection against Mitochondrial and Metal Toxicity Depends on Functional Lipid Binding Sites in ATP13A2 by Vangheluwe, Peter, Eggermont, Jan, Baekelandt, Veerle, Van Den Haute, Chris, Demirsoy, Seyma, Holemans, Tine, van Veen, Sarah, Martin, Shaun, Agostinis, Patrizia

“…The late endo-/lysosomal P-type ATPase ATP13A2 (PARK9) is implicated in Parkinson’s disease (PD) and Kufor-Rakeb syndrome, early-onset atypical Parkinsonism…”
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ATP13A2 deficiency disrupts lysosomal polyamine export by van Veen, Sarah, Martin, Shaun, Van den Haute, Chris, Benoy, Veronick, Lyons, Joseph, Vanhoutte, Roeland, Kahler, Jan Pascal, Decuypere, Jean-Paul, Gelders, Géraldine, Lambie, Eric, Zielich, Jeffrey, Swinnen, Johannes V., Annaert, Wim, Agostinis, Patrizia, Ghesquière, Bart, Verhelst, Steven, Baekelandt, Veerle, Eggermont, Jan, Vangheluwe, Peter

“…ATP13A2 (PARK9) is a late endolysosomal transporter that is genetically implicated in a spectrum of neurodegenerative disorders, including Kufor-Rakeb…”
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Loss-of-function mutations in the ATP13A2/PARK9 gene cause complicated hereditary spastic paraplegia (SPG78) by Estrada-Cuzcano, Alejandro, Martin, Shaun, Chamova, Teodora, Synofzik, Matthis, Timmann, Dagmar, Holemans, Tine, Andreeva, Albena, Reichbauer, Jennifer, De Rycke, Riet, Chang, Dae-In, van Veen, Sarah, Samuel, Jean, Schöls, Ludger, Pöppel, Thorsten, Mollerup Sørensen, Danny, Asselbergh, Bob, Klein, Christine, Zuchner, Stephan, Jordanova, Albena, Vangheluwe, Peter, Tournev, Ivailo, Schüle, Rebecca

“…Hereditary spastic paraplegias are heterogeneous neurodegenerative disorders characterized by progressive spasticity of the lower limbs due to degeneration of…”
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Cover Feature: Clickable Polyamine Derivatives as Chemical Probes for the Polyamine Transport System (ChemBioChem 9/2018) by Vanhoutte, Roeland, Kahler, Jan Pascal, Martin, Shaun, van Veen, Sarah, Verhelst, Steven H. L.

“…The cover feature picture shows how an azido‐functionalized polyamine, clicked to a fluorphore, can be used as a tool to hijack the polyamine transport system…”
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Polyamine Transport Assay Using Reconstituted Yeast Membranes by Van Veen, Sarah, Martin, Shaun, Schuermans, Marleen, Vangheluwe, Peter

“…ATP13A2/PARK9 is a late endo-/lysosomal P5B transport ATPase that is associated with several neurodegenerative disorders. We recently characterized ATP13A2 as…”
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lipid switch unlocks Parkinson’s disease-associated ATP13A2 by Holemans, Tine, Danny Mollerup Sørensen, Sarah van Veen, Shaun Martin, Diane Hermans, Gerdi Christine Kemmer, Chris Van den Haute, Veerle Baekelandt, Thomas Günther Pomorski, Patrizia Agostinis, Frank Wuytack, Michael Palmgren, Jan Eggermont, Peter Vangheluwe

“…ATP13A2 is a lysosomal transporter that is genetically linked to an autosomal recessive variant of Parkinson’s disease and confers protection against…”
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