Search Results - "van Veen, Hendrik W."

Structures and functions of mitochondrial ABC transporters by Schaedler, Theresia A, Faust, Belinda, Shintre, Chitra A, Carpenter, Elisabeth P, Srinivasan, Vasundara, van Veen, Hendrik W, Balk, Janneke

“…A small number of physiologically important ATP-binding cassette (ABC) transporters are found in mitochondria. Most are half transporters of the B group…”
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Promiscuous partnering and independent activity of MexB, the multidrug transporter protein from Pseudomonas aeruginosa by Welch, Alexander, Awah, Chidiebere U, Jing, Shiheng, van Veen, Hendrik W, Venter, Henrietta

“…The MexAB-OprM drug efflux pump is central to multidrug resistance of Pseudomonas aeruginosa. The ability of the tripartite protein to confer drug resistance…”
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Energetics of lipid transport by the ABC transporter MsbA is lipid dependent by Guo, Dawei, Singh, Himansha, Shimoyama, Atsushi, Guffick, Charlotte, Tang, Yakun, Rowe, Sam M., Noel, Timothy, Spring, David R., Fukase, Koichi, van Veen, Hendrik W.

“…The ABC multidrug exporter MsbA mediates the translocation of lipopolysaccharides and phospholipids across the plasma membrane in Gram-negative bacteria…”
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Basic residues R260 and K357 affect the conformational dynamics of the major facilitator superfamily multidrug transporter LmrP by Wang, Wei, van Veen, Hendrik W

“…Secondary-active multidrug transporters can confer resistance on cells to pharmaceuticals by mediating their extrusion away from intracellular targets via…”
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Structure, mechanism and cooperation of bacterial multidrug transporters by Du, Dijun, van Veen, Hendrik W, Murakami, Satoshi, Pos, Klaas M, Luisi, Ben F

“…•Structure-based mechanisms are available for five major classes of multi-drug transporters.•Three transporter classes form tripartite assemblies spanning the…”
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Crystal structure of tripartite-type ABC transporter MacB from Acinetobacter baumannii by Okada, Ui, Yamashita, Eiki, Neuberger, Arthur, Morimoto, Mayu, van Veen, Hendrik W., Murakami, Satoshi

“…The MacA–MacB–TolC tripartite complex is a transmembrane machine that spans both plasma membrane and outer membrane and actively extrudes substrates, including…”
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Engineered MATE multidrug transporters reveal two functionally distinct ion-coupling pathways in NorM from Vibrio cholerae by Raturi, Sagar, Nair, Asha V., Shinoda, Keiko, Singh, Himansha, Bai, Boyan, Murakami, Satoshi, Fujitani, Hideaki, van Veen, Hendrik W.

“…Multidrug and toxic compound extrusion (MATE) transport proteins confer multidrug resistance on pathogenic microorganisms and affect pharmacokinetics in…”
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A Conserved Mitochondrial ATP-binding Cassette Transporter Exports Glutathione Polysulfide for Cytosolic Metal Cofactor Assembly by Schaedler, Theresia A., Thornton, Jeremy D., Kruse, Inga, Schwarzländer, Markus, Meyer, Andreas J., van Veen, Hendrik W., Balk, Janneke

“…An ATP-binding cassette transporter located in the inner mitochondrial membrane is involved in iron-sulfur cluster and molybdenum cofactor assembly in the…”
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Structure of an antibacterial peptide ATP-binding cassette transporter in a novel outward occluded state by Choudhury, Hassanul G., Tong, Zhen, Mathavan, Indran, Li, Yanyan, Iwata, So, Zirah, Séverine, Rebuffat, Sylvie, van Veen, Hendrik W., Beis, Konstantinos

“…Enterobacteriaceae produce antimicrobial peptides for survival under nutrient starvation. Microcin J25 (MccJ25) is an antimicrobial peptide with a unique lasso…”
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Multidrug Transport Protein NorM from Vibrio cholerae Simultaneously Couples to Sodium- and Proton-Motive Force by Jin, Yoonhee, Nair, Asha, van Veen, Hendrik W.

“…Membrane transporters belonging to the multidrug and toxic compound extrusion family mediate the efflux of unrelated pharmaceuticals from the interior of the…”
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Substrate Binding Stabilizes a Pre-translocation Intermediate in the ATP-binding Cassette Transport Protein MsbA by Doshi, Rupak, van Veen, Hendrik W.

“…ATP-binding cassette (ABC) transporters belong to one of the largest protein superfamilies that expands from prokaryotes to man. Recent x-ray crystal…”
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Tuning the drug efflux activity of an ABC transporter in vivo by in vitro selected DARPin binders by Seeger, Markus A, Mittal, Anshumali, Velamakanni, Saroj, Hohl, Michael, Schauer, Stefan, Salaa, Ihsene, Grütter, Markus G, van Veen, Hendrik W

“…ABC transporters use the energy from binding and hydrolysis of ATP to import or extrude substrates across the membrane. Using ribosome display, we raised…”
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Arginine-482 is not essential for transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance protein (ABCG2) by Janvilisri, Tavan, Shahi, Sanjay, Venter, Henrietta, Balakrishnan, Lekshmy, van Veen, Hendrik W

“…The human BCRP (breast cancer resistance protein, also known as ABCG2) is an ABC (ATP-binding cassette) transporter that extrudes various anticancer drugs from…”
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Tripartite transporters as mechanotransmitters in periplasmic alternating‐access mechanisms by Murakami, Satoshi, Okada, Ui, Veen, Hendrik W.

“…To remove xenobiotics from the periplasmic space, Gram‐negative bacteria utilise unique tripartite efflux systems in which a molecular engine in the plasma…”
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Molecular basis of multidrug transport by ABC transporters by Seeger, Markus A., van Veen, Hendrik W.

“…Multidrug ABC transporters such as the human multidrug resistance P-glycoprotein (ABCB1) play an important role in the extrusion of drugs from the cell and…”
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ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled by Singh, Himansha, Velamakanni, Saroj, Deery, Michael J., Howard, Julie, Wei, Shen L., van Veen, Hendrik W.

“…ATP-binding cassette transporters mediate the transbilayer movement of a vast number of substrates in or out of cells in organisms ranging from bacteria to…”
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Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1 by Gutmann, Daniel A.P., Ward, Andrew, Urbatsch, Ina L., Chang, Geoffrey, van Veen, Hendrik W.

“…Multidrug ABC transporters can transport a wide range of drugs from the cell. Ongoing studies of the prototype mammalian multidrug resistance ATP-binding…”
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Structure of the MacAB–TolC ABC-type tripartite multidrug efflux pump by Fitzpatrick, Anthony W. P., Llabrés, Salomé, Neuberger, Arthur, Blaza, James N., Bai, Xiao-Chen, Okada, Ui, Murakami, Satoshi, van Veen, Hendrik W., Zachariae, Ulrich, Scheres, Sjors H. W., Luisi, Ben F., Du, Dijun

“…The MacA–MacB–TolC assembly of Escherichia coli is a transmembrane machine that spans the cell envelope and actively extrudes substrates, including macrolide…”
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Hoechst 33342 Is a Hidden "Janus" amongst Substrates for the Multidrug Efflux Pump LmrP by Neuberger, Arthur, van Veen, Hendrik W

“…Multidrug transporters mediate the active extrusion of antibiotics and toxic ions from the cell. This reaction is thought to be based on a switch of the…”
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Mass spectrometry of membrane transporters reveals subunit stoichiometry and interactions by Bavro, Vassiliy N, Miguel, Ricardo Núñez, Schaedler, Theresia A, Robinson, Carol V, Zhou, Min, Barrera, Nelson P, van Veen, Hendrik W, Venter, Henrietta, Seeger, Markus A, Tate, Christopher G, Isaacson, Shoshanna C, Walmsley, Adrian R, Welch, Alex, Korkhov, Vladimir M

“…We describe a general mass spectrometry approach to determine subunit stoichiometry and lipid binding in intact membrane protein complexes. By exploring…”
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