Search Results - "van Veelen, PA"

Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications by Kissel, T, Reijm, S, Slot, L M, Cavallari, M, Wortel, C M, Vergroesen, R D, Stoeken-Rijsbergen, G, Kwekkeboom, J C, Kampstra, Asb, Levarht, Ewn, Drijfhout, J W, Bang, H, Bonger, K M, Janssen, Gmc, van Veelen, P A, Huizinga, Twj, Scherer, H U, Reth, M, Toes, Rem

“…Autoantibodies against antigens carrying distinct post-translational modifications (PTMs), such as citrulline, homocitrulline or acetyllysine, are hallmarks of…”
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Virus specific CD8+ T-cells accumulate, but do not recognize antigen, in the atherosclerotic lesion by De Jong, M, Depuydt, MAC, Lozano Vigario, F, Van Veelen, PA, Kuiper, J, Slutter, BA

“…Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main funding source(s): ERA CVD Dutch Heart Foundation Viral…”
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The SysteMHC Atlas project by Shao, Wenguang, Pedrioli, Patrick G A, Wolski, Witold, Scurtescu, Cristian, Schmid, Emanuel, Vizcaíno, Juan A, Courcelles, Mathieu, Schuster, Heiko, Kowalewski, Daniel, Marino, Fabio, Arlehamn, Cecilia S L, Vaughan, Kerrie, Peters, Bjoern, Sette, Alessandro, Ottenhoff, Tom H M, Meijgaarden, Krista E, Nieuwenhuizen, Natalie, Kaufmann, Stefan H E, Schlapbach, Ralph, Castle, John C, Nesvizhskii, Alexey I, Nielsen, Morten, Deutsch, Eric W, Campbell, David S, Moritz, Robert L, Zubarev, Roman A, Ytterberg, Anders Jimmy, Purcell, Anthony W, Marcilla, Miguel, Paradela, Alberto, Wang, Qi, Costello, Catherine E, Ternette, Nicola, van Veelen, Peter A, van Els, Cécile A C M, Heck, Albert J R, de Souza, Gustavo A, Sollid, Ludvig M, Admon, Arie, Stevanovic, Stefan, Rammensee, Hans-Georg, Thibault, Pierre, Perreault, Claude, Bassani-Sternberg, Michal, Aebersold, Ruedi, Caron, Etienne

“…Abstract Mass spectrometry (MS)-based immunopeptidomics investigates the repertoire of peptides presented at the cell surface by major histocompatibility…”
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The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K by Mons, Elma, Jansen, Ineke D. C, Loboda, Jure, van Doodewaerd, Bjorn R, Hermans, Jill, Verdoes, Martijn, van Boeckel, Constant A. A, van Veelen, Peter A, Turk, Boris, Turk, Dusan, Ovaa, Huib

“…Irreversible covalent inhibitors can have a beneficial pharmacokinetic/pharmacodynamics profile but are still often avoided due to the risk of indiscriminate…”
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T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes by Ali, Muhammad, Giannakopoulou, Eirini, Li, Yingqian, Lehander, Madeleine, Virding Culleton, Stina, Yang, Weiwen, Knetter, Cathrine, Odabasi, Mete Can, Bollineni, Ravi Chand, Yang, Xinbo, Foldvari, Zsofia, Böschen, Maxi-Lu, Taraldsrud, Eli, Strønen, Erlend, Toebes, Mireille, Hillen, Amy, Mazzi, Stefania, de Ru, Arnoud H., Janssen, George M. C., Kolstad, Arne, Tjønnfjord, Geir Erland, Lie, Benedicte A., Griffioen, Marieke, Lehmann, Sören, Osnes, Liv Toril, Buechner, Jochen, Garcia, K. Christopher, Schumacher, Ton N., van Veelen, Peter A., Leisegang, Matthias, Jacobsen, Sten Eirik W., Woll, Petter, Olweus, Johanna

“…Unlike chimeric antigen receptors, T-cell receptors (TCRs) can recognize intracellular targets presented on human leukocyte antigen (HLA) molecules. Here we…”
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Human islets and dendritic cells generate post‐translationally modified islet autoantigens by McLaughlin, R. J., de Haan, A., Zaldumbide, A., de Koning, E. J., de Ru, A. H., van Veelen, P. A., van Lummel, M., Roep, B. O.

“…Summary The initiation of type 1 diabetes (T1D) requires a break in peripheral tolerance. New insights into neoepitope formation indicate that…”
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Autoreactive CD8 T Cells Associated with β Cell Destruction in Type 1 Diabetes by Gabrielle G. M. Pinkse, Odette H. M. Tysma, Cees A. M. Bergen, Michel G. D. Kester, Ossendorp, Ferry, van Veelen, Peter A., Bart Keymeulen, Pipeleers, Danny, Drijfhout, Jan W., Roep, Bart O., van Rood, Johannes

“…Type 1 diabetes is a T cell-mediated autoimmune disease, and insulin is an important target of the autoimmune response associated with β cell destruction. The…”
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Methylation of Arginine Residues Interferes with Citrullination by Peptidylarginine Deiminases in vitro by Raijmakers, Reinout, Zendman, Albert J.W., Egberts, Wilma Vree, Vossenaar, Erik R., Raats, Jos, Soede-Huijbregts, Claudia, Rutjes, Floris P.J.T., van Veelen, Peter A., Drijfhout, Jan W., Pruijn, Ger J.M.

“…Peptidylarginine deiminase (PAD) enzymes catalyze the conversion of arginine residues in proteins to citrulline residues. Citrulline is a non-standard amino…”
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Characterization of cereal toxicity for celiac disease patients based on protein homology in grains by Vader, L.Willemijn, Stepniak, Dariusz T, Bunnik, Evelien M, Kooy, Yvonne M.C, De Haan, Willeke, Drijfhout, Jan Wouter, Van Veelen, Peter A, Koning, Frits

“…Background & Aims : Celiac disease is caused by T-cell responses to wheat gluten-derived peptides. The presence of such peptides in other widely consumed…”
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Alpha-gliadin genes from the A, B, and D genomes of wheat contain different sets of celiac disease epitopes by van Herpen, Teun W J M, Goryunova, Svetlana V, van der Schoot, Johanna, Mitreva, Makedonka, Salentijn, Elma, Vorst, Oscar, Schenk, Martijn F, van Veelen, Peter A, Koning, Frits, van Soest, Loek J M, Vosman, Ben, Bosch, Dirk, Hamer, Rob J, Gilissen, Luud J W J, Smulders, Marinus J M

“…Bread wheat (Triticum aestivum) is an important staple food. However, wheat gluten proteins cause celiac disease (CD) in 0.5 to 1% of the general population…”
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Thrombocidins, Microbicidal Proteins from Human Blood Platelets, Are C-terminal Deletion Products of CXC Chemokines by Krijgsveld, Jeroen, Zaat, Sebastian A.J., Meeldijk, Jan, van Veelen, Peter A., Fang, Gang, Poolman, Bert, Brandt, Ernst, Ehlert, Jan E., Kuijpers, Alma J., Engbers, Gerard H.M., Feijen, Jan, Dankert, Jacob

“…Antibacterial proteins are components of the innate immune system found in many organisms and produced by a variety of cell types. Human blood platelets…”
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Efficient Identification of Novel Hla-A0201–Presented Cytotoxic T Lymphocyte Epitopes in the Widely Expressed Tumor Antigen Prame by Proteasome-Mediated Digestion Analysis by Kessler, Jan H., Beekman, Nico J., Bres-Vloemans, Sandra A., Verdijk, Pauline, van Veelen, Peter A., Kloosterman-Joosten, Antoinette M., Vissers, Debby C.J., ten Bosch, George J.A., Kester, Michel G.D., Sijts, Alice, Drijfhout, Jan Wouter, Ossendorp, Ferry, Offringa, Rienk, Melief, Cornelis J.M.

“…We report the efficient identification of four human histocompatibility leukocyte antigen (HLA)-A*0201–presented cytotoxic T lymphocyte (CTL) epitopes in the…”
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Cytomegalovirus in Autoimmunity: T Cell Crossreactivity to Viral Antigen and Autoantigen Glutamic Acid Decarboxylase by Hiemstra, Hoebert S., Schloot, Nanette C., van Veelen, Peter A., Sabine J. M. Willemen, Kees L. M. C. Franken, van Rood, Jon J., René R. P. de Vries, Chaudhuri, Abhijit, Behan, Peter O., Drijfhout, Jan W., Roep, Bart O.

“…Antigens of pathogenic microbes that mimic autoantigens are thought to be responsible for the activation of autoreactive T cells. Viral infections have been…”
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Small Intestinal T Cells of Celiac Disease Patients Recognize a Natural Pepsin Fragment of Gliadin by Van De Wal, Yvonne, Yvonne M. C. Kooy, Van Veelen, Peter A., Pena, Salvador A., Mearin, Luisa M., Molberg, Oyvind, Knut E. A. Lundin, Sollid, Ludvig M., Mutis, Tuna, Benckhuijsen, Willemien E., Drijfhout, Jan Wouter, Koning, Frits

“…Celiac disease is a common severe intestinal disease resulting from intolerance to dietary wheat gluten and related proteins. The large majority of patients…”
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Antibody Response Against Perlecan and Collagen Types IV and VI in Chronic Renal Allograft Rejection in the Rat by Joosten, Simone A., van Dixhoorn, Mieneke G.A., Borrias, Maria C., Benediktsson, Hallgrimur, van Veelen, Peter A., van Kooten, Cees, Paul, Leendert C.

“…Chronic rejection is the leading cause of late renal transplant failure. Various structural lesions are observed in grafts undergoing chronic rejection…”
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Morphological changes during dendritic cell maturation correlate with cofilin activation and translocation to the cell membrane by Verdijk, Pauline, van Veelen, Peter A., de Ru, Arnoud H., Hensbergen, Paul J., Mizuno, Kensaku, Koerten, Henk K., Koning, Frits, Tensen, Cornelis P., Mommaas, A. Mieke

“…Upon activation, tissue residing immature dendritic cells (DC) start to migrate towards the draining lymph node and mature into efficient antigen‐presenting…”
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Efficiency and Mechanism of Antigen-specific CD8+ T-cell Activation Using Synthetic Long Peptides by ZANDVLIET, Maarten L, KESTER, Michel G. D, LIEMPT, Ellis Van, DE RU, Arnoud H, VEELEN, Peter A. Van, GRIFFIOEN, Marieke, GUCHELAAR, Henk-Jan, FREDERIK FALKENBURG, J. H, MEIJ, Pauline

“…Synthetic long peptides that contain immunogenic T-cell epitopes have been used to induce activation of antigen-specific CD8 T cells in vitro for immune…”
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MHC Class I Antigen Processing of an Adenovirus CTL Epitope Is Linked to the Levels of Immunoproteasomes in Infected Cells by Sijts, Alice J. A. M, Standera, Sybille, Toes, Rene E. M, Ruppert, Thomas, Beekman, Nico J. C. M, van Veelen, Peter A, Ossendorp, Ferry A, Melief, Cornelis J. M, Kloetzel, Peter M

“…Proteasomes are the major source for the generation of peptides bound by MHC class I molecules. To study the functional relevance of the IFN-gamma-inducible…”
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T-cell recognition of HLA-DQ2-bound gluten peptides can be influenced by an N-terminal proline at p-1 by Stepniak, Dariusz, Vader, L Willemijn, Kooy, Yvonne, van Veelen, Peter A, Moustakas, Antonis, Papandreou, Nikolaos A, Eliopoulos, Elias, Drijfhout, Jan Wouter, Papadopoulos, George K, Koning, Frits

“…Recent research has implicated a large number of gluten-derived peptides in the pathogenesis of celiac disease, a preponderantly HLA-DQ2-associated disorder…”
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Abrogation of CTL Epitope Processing by Single Amino Acid Substitution Flanking the C-Terminal Proteasome Cleavage Site by Beekman, Nico J, van Veelen, Peter A, van Hall, Thorbald, Neisig, Anne, Sijts, Alice, Camps, Marcel, Kloetzel, Peter-M, Neefjes, Jacques J, Melief, Cornelis J, Ossendorp, Ferry

“…CTL directed against the Moloney murine leukemia virus (MuLV) epitope SSWDFITV recognize Moloney MuLV-induced tumor cells, but do not recognize cells…”
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