Relationship between diameter asymmetry and blood flow in the pre-communicating (A1) segment of the anterior cerebral arteries

Relationship between diameter asymmetry and blood flow in the pre-communicating (A1) segment of the anterior cerebral arteries

Asymmetry in diameter between pre-communicating (A1) segments of the anterior cerebral arteries is related to anterior communicating artery aneurysm formation. Diameter asymmetry definitions vary and have not been related to blood flow measurements using the same imaging modality. We aimed to evalua...

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Bibliographic Details
Published in:Journal of neuroradiology Vol. 50; no. 4; pp. 402 - 406
Main Authors: van Tuijl, RJ, Ruigrok, YM, Ophelders, MEH, Vos, IN, van der Schaaf, IC, Zwanenburg, JJM, Velthuis, BK
Format: Journal Article
Language:English
Published: France Elsevier Masson SAS 01-06-2023
Subjects:
3T MRI
4-dimensional phase-contrast MRI
A1-diameter
Anterior Cerebral Artery - diagnostic imaging
Blood flow
Cerebral Angiography - methods
Cerebral Arteries - diagnostic imaging
Female
Hemodynamics
Humans
Intracranial Aneurysm
Male
Pre-communicating arteries
Velocity pulsatility
ICA
Velocity pulsatility
CoW
MCA
A1-diameter
Pre-communicating arteries
UIA
4D-PC
A1-segment
vPI
Blood flow
TOF-MRA
3T MRI
4-dimensional phase-contrast MRI
IA
ACA
Acom
DC
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Summary:Asymmetry in diameter between pre-communicating (A1) segments of the anterior cerebral arteries is related to anterior communicating artery aneurysm formation. Diameter asymmetry definitions vary and have not been related to blood flow measurements using the same imaging modality. We aimed to evaluate the relationship between A1-diameter asymmetry and blood flow asymmetry and to define a hemodynamically significant cut-off value for A1-diameter asymmetry. We assessed sex differences between different groups of A1-asymmetry. 3-Tesla time-of-flight MRA and 4D-phase-contrast MRI were performed in 122 healthy participants. Diameter and blood flow measurements were performed halfway in both A1-segments. Participants were subdivided based on A1-diameter asymmetry: ≤10% (symmetric); 11–20%; 21–30%; 31–40%; and >40% (increasing asymmetry) groups. We studied the relationship between A1-diameter asymmetry and corresponding flow asymmetry (scatterplot and correlation). A hemodynamic-based cutoff value for A1-asymmetry was determined by comparing dominant A1 blood flow in the asymmetry groups to the mean blood flow of the symmetric A1-group (linear mixed-effects model). Sex-related differences in A1-diameter, blood flow and asymmetry were assessed with t-tests. A1-diameter asymmetry was linearly related to blood flow asymmetry between dominant and non-dominant sides. A1-diameter asymmetry >30% yielded statistically significant increased blood flow in the dominant A1 compared to symmetric A1s. Men had statistically significant larger A1-diameters, higher blood flow and a similar degree of A1-diameter asymmetry compared to women. A1-diameter asymmetry is linearly related to blood flow asymmetry. A >30% A1-asymmetry can be used as hemodynamically significant cut-off value. There were no sex-related differences in A1-diameter asymmetry. [Display omitted]
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ISSN:0150-9861
DOI:10.1016/j.neurad.2022.10.004