Search Results - "van Tilburg, Erica W."

Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation by Albers, Harald M.H.G, Dong, Anping, van Meeteren, Laurens A, Egan, David A, Sunkara, Manjula, van Tilburg, Erica W, Schuurman, Karianne, van Tellingen, Olaf, Morris, Andrew J, Smyth, Susan S, Moolenaar, Wouter H, Ovaa, Huib

“…Autotaxin (ATX) is a secreted nucleotide pyrophosphatase/phosphodiesterase that functions as a lysophospholipase D to produce the lipid mediator…”
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Discovery and Optimization of Boronic Acid Based Inhibitors of Autotaxin by Albers, Harald M. H. G, van Meeteren, Laurens A, Egan, David A, van Tilburg, Erica W, Moolenaar, Wouter H, Ovaa, Huib

“…Autotaxin (ATX) is an extracellular enzyme that hydrolyzes lysophosphatidylcholine (LPC) to produce the lipid mediator lysophosphatidic acid (LPA). The ATX−LPA…”
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Development of an Activity-Based Probe for Autotaxin by Cavalli, Silvia, Houben, Anna J. S., Albers, Harald M. H. G., van Tilburg, Erica W., de Ru, Arnoud, Aoki, Junken, van Veelen, Peter, Moolenaar, Wouter H., Ovaa, Huib

“…Autotaxin (ATX), or ecto‐nucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), is a secreted lysophospholipase D that hydrolyses lysophosphatidylcholine into…”
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Simplified parametric methods for [ 11C]PIB studies by Yaqub, Maqsood, Tolboom, Nelleke, Boellaard, Ronald, van Berckel, Bart N.M., van Tilburg, Erica W., Luurtsema, Gert, Scheltens, Philip, Lammertsma, Adriaan A.

“…The purpose of the present study was to evaluate the performance of various parametric reference tissue models for quantification of [ 11C]PIB studies. Several…”
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5‘-O-Alkyl Ethers of N,2-Substituted Adenosine Derivatives:  Partial Agonists for the Adenosine A1 and A3 Receptors by van Tilburg, Erica W, van der Klein, Pieter A. M, von Frijtag Drabbe Künzel, Jacobien, de Groote, Miriam, Stannek, Christina, Lorenzen, Anna, IJzerman, Ad P

“…New N,5‘-di- and N,2,5‘-trisubstituted adenosine derivatives were synthesized in good overall yields. Appropriate 5-O-alkyl-substituted ribose moieties were…”
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Profiling Proteasome Activity in Tissue with Fluorescent Probes by Berkers, Celia R, van Leeuwen, Fijs W. B, Groothuis, Tom A, Peperzak, Victor, van Tilburg, Erica W, Borst, Jannie, Neefjes, Jacques J, Ovaa, Huib

“…With proteasome inhibitors in use in the clinic for the treatment of multiple myeloma and with clinical trials in progress investigating the treatment of a…”
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2,5‘-Disubstituted Adenosine Derivatives:  Evaluation of Selectivity and Efficacy for the Adenosine A1, A2A, and A3 Receptor by van Tilburg, Erica W, von Frijtag Drabbe Künzel, Jacobien, de Groote, Miriam, IJzerman, Ad P

“…Novel 2,5‘-disubstituted adenosine derivatives were synthesized in good overall yields starting from commercially available guanosine. Binding affinities were…”
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2,8-Disubstituted adenosine derivatives as partial agonists for the adenosine A2A receptor by VAN TILBURG, Erica W, GREMMEN, Matty, VON FRIJTAG DRABBE KÜNZEL, Jacobien, DE GROOTE, Miriam, IJZERMAN, Ad P

“…Novel 2,8-disubstituted adenosine derivatives were synthesized in good overall yields starting from 2-iodoadenosine. Binding affinities were determined for rat…”
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Extracellular adenosine-induced apoptosis in mouse neuroblastoma cells studies on involvement of adenosine receptors and adenosine uptake by Schrier, S.Mariette, van Tilburg, Erica W, van der Meulen, Hans, Ijzerman, Ad P, Mulder, Gerald J, Nagelkerke, J.Fred

“…The induction of apoptosis by adenosine was studied in the mouse neuroblastoma cell line N1E-115. Apoptosis was characterized by fluorescence and electron…”
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One-pot synthesis of [11C]ureas via triphenylphosphinimines by van Tilburg, Erica W., Windhorst, Albert D., van der Mey, Margreet, Herscheid, Jacobus D. M.

“…A series of 11C‐labeled ureas was prepared using a rapid and efficient one‐pot procedure. First, the intermediate [11C]phenylisocyanate was formed with…”
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Functional role of adenosine receptor subtypes in the regulation of blood–brain barrier permeability: possible implications for the design of synthetic adenosine derivatives by Schaddelee, Marloes P., Voorwinden, Heleen L., van Tilburg, Erica W., Pateman, Tony J., Ijzerman, Adriaan P., Danhof, Meindert, de Boer, Albertus G.

“…The objective of this investigation was to determine the functional role of adenosine receptor subtypes in the regulation of blood–brain barrier (BBB)…”
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Extracellular adenosine-induced apoptosis in mouse neuroblastoma cells studies on involvement of adenosine receptors and adenosine uptake11Abbreviations: NECA, 5′-(N-ethylcarboxamido)adenosine; AMDA, 5′-amino-5′-deoxyadenosine; CPA, N6-cyclopentyladenosine; NBI, nitrobenzylthioinosine; 2-Cl-IB-MECA, 2-chloro-N6-(3-iodobenzyl)adenosine-5′-N-methyluronamide; AMV–RT, Avian myeloblastosis virus–reverse transcriptase; PCR, polymerase chain reaction; DEVD-AMC, N-acetyl-Asp-Glu-Val-Asp-7-amino-4-methyl by Schrier, S.Mariette, van Tilburg, Erica W, van der Meulen, Hans, Ijzerman, Ad P, Mulder, Gerald J, Nagelkerke, J.Fred

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Cover Picture: Development of an Activity-Based Probe for Autotaxin (ChemBioChem 16/2010) by Cavalli, Silvia, Houben, Anna J. S., Albers, Harald M. H. G., van Tilburg, Erica W., de Ru, Arnoud, Aoki, Junken, van Veelen, Peter, Moolenaar, Wouter H., Ovaa, Huib

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Why are A(2B) receptors low-affinity adenosine receptors? Mutation of Asn273 to Tyr increases affinity of human A(2B) receptor for 2-(1-Hexynyl)adenosine by Beukers, M W, den Dulk, H, van Tilburg, E W, Brouwer, J, Ijzerman, A P

“…Adenosine A(2B) receptors are known as low-affinity receptors due to their modest-to-negligible affinity for adenosine and prototypic agonists. Despite…”
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2,5'-Disubstituted adenosine derivatives: evaluation of selectivity and efficacy for the adenosine A(1), A(2A), and A(3) receptor by van Tilburg, Erica W, von Frijtag Drabbe Kunzel, Jacobien, de Groote, Miriam, IJzerman, Ad P

“…Novel 2,5'-disubstituted adenosine derivatives were synthesized in good overall yields starting from commercially available guanosine. Binding affinities were…”
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2,5‘-Disubstituted Adenosine Derivatives:  Evaluation of Selectivity and Efficacy for the Adenosine A 1 , A 2A , and A 3 Receptor by van Tilburg, Erica W., von Frijtag Drabbe Künzel, Jacobien, de Groote, Miriam, IJzerman, Ad P.

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2,8-Disubstituted adenosine derivatives as partial agonists for the adenosine A 2A receptor by van Tilburg, Erica W, Gremmen, Matty, von Frijtag Drabbe Künzel, Jacobien, de Groote, Miriam, IJzerman, Ad P

“…Novel 2,8-disubstituted adenosine derivatives were synthesized in good overall yields starting from 2-iodoadenosine. Binding affinities were determined for rat…”
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5‘- O -Alkyl Ethers of N ,2-Substituted Adenosine Derivatives:  Partial Agonists for the Adenosine A 1 and A 3 Receptors by van Tilburg, Erica W., van der Klein, Pieter A. M., von Frijtag Drabbe Künzel, Jacobien, de Groote, Miriam, Stannek, Christina, Lorenzen, Anna, IJzerman, Ad P.

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N 6 ,5‘-Disubstituted Adenosine Derivatives as Partial Agonists for the Human Adenosine A 3 Receptor by van Tilburg, Erica W., von Frijtag Drabbe Künzel, Jacobien, de Groote, Miriam, Vollinga, Roel C., Lorenzen, Anna, IJzerman, Ad P.

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N6,5‘-Disubstituted Adenosine Derivatives as Partial Agonists for the Human Adenosine A3 Receptor by VAN TILBURG, Erica W., VON FRIJTAG DRABBE KüNZEL, Jacobien, DE GROOTE, Miriam, VOLLINGA, Roel C., LORENZEN, Anna, IJZERMAN, Ad P.

“…5'-(Alkylthio)-substituted analogues of N6-benzyl- and N6-(3-iodobenzyl)adenosine were synthesized in 37-61% overall yields. The affinities of these compounds…”
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