Search Results - "van Tilburg, E W"

Radiosynthesis of [11C]docetaxel by van Tilburg, E. W., Franssen, E. J. F., van der Hoeven, J. J. M., van der Meij, M., Elshove, D., Lammertsma, A. A., Windhorst, A. D.

“…Docetaxel (Taxotere®) is an accepted chemotherapeutic agent for the treatment of breast cancer and non‐small cell lung cancers. A potential means of predicting…”
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Improved and semi-automated GMP-compliant radiosynthesis of [ 11C]docetaxel by van Tilburg, E.W., Mooijer, M.P.J., Brinkhorst, J., van der Meij, M., Windhorst, A.D.

“…[ 11C]Docetaxel (Taxotere ®) has been synthesized via an improved synthesis route, which involves a more efficient intermediate removal of the excess…”
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5‘-O-Alkyl Ethers of N,2-Substituted Adenosine Derivatives:  Partial Agonists for the Adenosine A1 and A3 Receptors by van Tilburg, Erica W, van der Klein, Pieter A. M, von Frijtag Drabbe Künzel, Jacobien, de Groote, Miriam, Stannek, Christina, Lorenzen, Anna, IJzerman, Ad P

“…New N,5‘-di- and N,2,5‘-trisubstituted adenosine derivatives were synthesized in good overall yields. Appropriate 5-O-alkyl-substituted ribose moieties were…”
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Substituted 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives as antagonists for the adenosine A1 receptor by VAN TILBURG, E. W, VAN DER KLEIN, P. A. M, DE GROOTE, M, BEUKERS, M. W, IJZERMAN, A. P

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Extracellular adenosine-induced apoptosis in mouse neuroblastoma cells studies on involvement of adenosine receptors and adenosine uptake by Schrier, S.Mariette, van Tilburg, Erica W, van der Meulen, Hans, Ijzerman, Ad P, Mulder, Gerald J, Nagelkerke, J.Fred

“…The induction of apoptosis by adenosine was studied in the mouse neuroblastoma cell line N1E-115. Apoptosis was characterized by fluorescence and electron…”
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Substituted 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives as antagonists for the adenosine A(1) receptor by van Tilburg, E W, van der Klein, P A, de Groote, M, Beukers, M W, IJzerman, A P

“…The synthesis and receptor binding of novel adenosine receptor antagonists is described. We found that non-xanthine 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole…”
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N6,5‘-Disubstituted Adenosine Derivatives as Partial Agonists for the Human Adenosine A3 Receptor by VAN TILBURG, Erica W., VON FRIJTAG DRABBE KüNZEL, Jacobien, DE GROOTE, Miriam, VOLLINGA, Roel C., LORENZEN, Anna, IJZERMAN, Ad P.

“…5'-(Alkylthio)-substituted analogues of N6-benzyl- and N6-(3-iodobenzyl)adenosine were synthesized in 37-61% overall yields. The affinities of these compounds…”
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Why are A(2B) receptors low-affinity adenosine receptors? Mutation of Asn273 to Tyr increases affinity of human A(2B) receptor for 2-(1-Hexynyl)adenosine by Beukers, M W, den Dulk, H, van Tilburg, E W, Brouwer, J, Ijzerman, A P

“…Adenosine A(2B) receptors are known as low-affinity receptors due to their modest-to-negligible affinity for adenosine and prototypic agonists. Despite…”
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2,5'-Disubstituted adenosine derivatives: evaluation of selectivity and efficacy for the adenosine A(1), A(2A), and A(3) receptor by van Tilburg, Erica W, von Frijtag Drabbe Kunzel, Jacobien, de Groote, Miriam, IJzerman, Ad P

“…Novel 2,5'-disubstituted adenosine derivatives were synthesized in good overall yields starting from commercially available guanosine. Binding affinities were…”
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One-pot synthesis of [11C]ureas via triphenylphosphinimines by van Tilburg, Erica W., Windhorst, Albert D., van der Mey, Margreet, Herscheid, Jacobus D. M.

“…A series of 11C‐labeled ureas was prepared using a rapid and efficient one‐pot procedure. First, the intermediate [11C]phenylisocyanate was formed with…”
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Functional role of adenosine receptor subtypes in the regulation of blood–brain barrier permeability: possible implications for the design of synthetic adenosine derivatives by Schaddelee, Marloes P., Voorwinden, Heleen L., van Tilburg, Erica W., Pateman, Tony J., Ijzerman, Adriaan P., Danhof, Meindert, de Boer, Albertus G.

“…The objective of this investigation was to determine the functional role of adenosine receptor subtypes in the regulation of blood–brain barrier (BBB)…”
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Medicinal chemistry of the human adenosine A3 receptor by van Tilburg, Erica W., van Muijlwijk-Koezen, Jacqueline E., Ijzerman, Adriaan P.

“…Partial agonists and antagonists were synthesized and evaluated biologically for extended pharmacologic characterization of the human adenosine A3 receptor…”
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