Search Results - "van Tellingen, O."

Overcoming the blood–brain tumor barrier for effective glioblastoma treatment by van Tellingen, O, Yetkin-Arik, B, de Gooijer, M.C, Wesseling, P, Wurdinger, T, de Vries, H.E

“…Abstract Gliomas are the most common primary brain tumors. Particularly in adult patients, the vast majority of gliomas belongs to the heterogeneous group of…”
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Therapy-resistant tumor microvascular endothelial cells contribute to treatment failure in glioblastoma multiforme by Borovski, T, Beke, P, van Tellingen, O, Rodermond, H M, Verhoeff, J J, Lascano, V, Daalhuisen, J B, Medema, J P, Sprick, M R

“…Glioblastoma multiforme (GBM) is a devastating disease with high mortality and poor prognosis. Cancer stem cells (CSCs) have recently been defined as a…”
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A validated HPLC-MS/MS method for simultaneously analyzing curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetra-hydrocurcumin and piperine in human plasma, urine or feces by Kroon, M.A.G.M., van Laarhoven, H.W.M., Swart, E.L., Kemper, E.M., van Tellingen, O.

“…The spice curcumin is supposed to have many different beneficial health effects. To understand the complete pharmacokinetics of curcumin we need an analytical…”
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Fractionated brain X-irradiation profoundly reduces hippocampal immature neuron numbers without affecting spontaneous behavior in mice by Kuil, L.E., Seigers, R., Loos, M., de Gooijer, M.C., Compter, A., Boogerd, W., van Tellingen, O., Smit, A.B., Schagen, S.B.

“…Whole brain radiotherapy (WBRT) is used to improve tumor control in patients with primary brain tumors, or brain metastasis from various primary tumors to…”
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Carcinogen and anticancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice by Vlaming, M L H, Mohrmann, K, Wagenaar, E, de Waart, D R, Elferink, R P J Oude, Lagas, J S, van Tellingen, O, Vainchtein, L D, Rosing, H, Beijnen, J H, Schellens, J H M, Schinkel, A H

“…The ATP-binding-cassette (ABC) transporter multidrug resistance protein (MRP) 2 (ABCC2) forms a natural barrier and efflux system for various (conjugates of)…”
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Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein by VAN ASPEREN, J, VAN TELLINGEN, O, TIJSSEN, F, SCHINKEL, A. H, BEIJNEN, J. H

“…To gain more insight into the pharmacological role of endogenous P-glycoprotein in the metabolism of the widely used substrate drug doxorubicin, we have…”
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Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs by Schinkel, A H, Smit, J J, van Tellingen, O, Beijnen, J H, Wagenaar, E, van Deemter, L, Mol, C A, van der Valk, M A, Robanus-Maandag, E C, te Riele, H P

“…We have generated mice homozygous for a disruption of the mdr1a (also called mdr3) gene, encoding a drug-transporting P-glycoprotein. The mice were viable and…”
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Cognitive impact of cytotoxic agents in mice by Seigers, R., Loos, M., Van Tellingen, O., Boogerd, W., Smit, A. B., Schagen, S. B.

“…Rationale and objectives Adjuvant chemotherapy is associated with changes in cognition in a subgroup of cancer patients. Chemotherapy is generally given as a…”
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Chemotherapy-related cognitive dysfunction: current animal studies and future directions by Seigers, R., Schagen, S. B., Van Tellingen, O., Dietrich, J.

“…Cognitive impairment is a potential long-term side effect of adjuvant chemotherapy that can have a major impact on the quality of life of cancer survivors…”
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Neurobiological changes by cytotoxic agents in mice by Seigers, R., Loos, M., Van Tellingen, O., Boogerd, W., Smit, A.B., Schagen, S.B.

“…•Adjuvant chemotherapy is frequently associated with cognitive change in patients.•Six cytotoxic agents were examined for their effect on brain functioning in…”
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The co-solvent Cremophor EL limits absorption of orally administered paclitaxel in cancer patients by MALINGRE, M. M, SCHELLENS, J. H. M, BEIJNEN, J. H, VAN TELLINGEN, O, OUWEHAND, M, BARDELMEIJER, H. A, ROSING, H, KOOPMAN, F. J, JANSEN, S. E, SCHOT, M. E, TEN BOKKEL HUININK, W. W

“…The purpose of this study was to investigate the effect of the co-solvents Cremophor EL and polysorbate 80 on the absorption of orally administered paclitaxel…”
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P-glycoprotein and Mrp1 collectively protect the bone marrow from vincristine-induced toxicity in vivo by van Tellingen, O, Buckle, T, Jonker, J W, van der Valk, M A, Beijnen, J H

“…ABC transporter proteins may protect haematopoietic progenitor cells from chemotherapy-induced toxicity. By using an in vitro colony-forming assay, we found…”
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Cremophor EL causes (pseudo-) non-linear pharmacokinetics of paclitaxel in patients by VAN TELLINGEN, O, HUIZING, M. T, PANDAY, V. R. N, SCHELLENS, J. H. M, NOOIJEN, W. J, BEIJNEN, J. H

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Altered Pharmacokinetics of Vinblastine in Mdr1a P-glycoprotein-Deficient Mice by van Asperen, Judith, Schinkel, Alfred H., Beijnen, Jos H., Nooijen, Willem J., Borst, Piet, van Tellingen, Olaf

“…Background: P-glycoprotein (Pgp) is a membrane protein that acts as an extrusion pump for many cytotoxic drugs. Pgp is expressed in normal tissues, and its…”
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Phase I trial and pharmacological study of a 3-hour paclitaxel infusion in children with refractory solid tumours: a SFOP study by DOZ, F, GENTET, J. C, CATALIN, J, PEIN, F, FRAPPAZ, D, CHASTAGNER, P, MORETTI, S, VASSAL, G, ARDITTI, J, VAN TELLINGEN, O, ILIADIS, A

“…The maximum tolerated dose of paclitaxel administered by 24-hour continuous infusion in children is known. Short infusion might offer equivalent antitumour…”
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Strategies to target drugs to gliomas and CNS metastases of solid tumors by Milojkovic Kerklaan, B., van Tellingen, O., Huitema, A. D. R., Beijnen, J. H., Boogerd, W., Schellens, J. H. M., Brandsma, D.

“…The treatment for central nervous system metastases of solid tumors and gliomas is limited as the blood–brain barrier (BBB) is an obstacle to systemic therapy…”
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Characterisation of tumour vasculature in mouse brain by USPIO contrast-enhanced MRI by Gambarota, G, Leenders, W, Maass, C, Wesseling, P, van der Kogel, B, van Tellingen, O, Heerschap, A

“…To enhance the success rate of antiangiogenic therapies in the clinic, it is crucial to identify parameters for tumour angiogenesis that can predict response…”
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16 Quadruple vertical targeting of an oncogenic pathway as a treatment strategy to prevent drug resistance by Neto, J, Van Tellingen, O, Villanueva, A, Bernards, R

“…IntroductionTargeted cancer drugs elicit powerful initial responses but far less long-term benefits. The emergence of therapy resistance often involves the…”
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Improved penetration of docetaxel into the brain by co-administration of inhibitors of P-glycoprotein by Kemper, E.M., Verheij, M., Boogerd, W., Beijnen, J.H., van Tellingen, O.

“…P-glycoprotein (Pgp) in the blood–brain barrier limits the brain's uptake of many anticancer drugs. We have investigated whether the Pgp inhibitors cyclosporin…”
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A population analysis of the pharmacokinetics of Cremophor EL using nonlinear mixed-effect modelling by VAN DEN BONGARD, H. J. G. D, MATHOT, R. A. A, VAN TELLINGEN, O, SCHELLENS, J. H. M, BEIJNEN, J. H

“…The purpose of this study was to develop a population pharmacokinetic model for Cremophor EL used as a formulation vehicle for paclitaxel. Plasma…”
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