Search Results - "van Steensel, B"

Role of the nuclear lamina in genome organization and gene expression by Peric-Hupkes, D, van Steensel, B

“…The nuclear lamina is a major structural component of metazoan nuclei that has long been thought to provide an anchoring site for interphase chromosomes and…”
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The inner nuclear membrane proteins Man1 and Ima1 link to two different types of chromatin at the nuclear periphery in S. pombe by Steglich, Babett, Filion, Guillaume, van Steensel, Bas, Ekwall, Karl

“…Metazoan chromatin at the nuclear periphery is generally characterized by lowly expressed genes and repressive chromatin marks and presents a sub-compartment…”
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Genomewide analysis of Drosophila GAGA factor target genes reveals context-dependent DNA binding by Steensel, B. van, Delrow, J, Bussemaker, H.J

“…The association of sequence-specific DNA-binding factors with their cognate target sequences in vivo depends on the local molecular context, yet this context…”
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A Human Telomeric Protein by Chong, Laura, van Steensel, Bas, Broccoli, Dominique, Erdjument-Bromage, Hediye, Hanish, John, Tempst, Paul, de Lange, Titia

“…Telomeres are multifunctional element that shield chromosome ends from degradation and end-to-end fusions, prevent activation of DNA damage checkpoints, and…”
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Fluorescent Labeling of Nascent RNA Reveals Transcription by RNA Polymerase II in Domains Scattered Throughout the Nucleus by Wansink, Derick G., Schul, Wouter, van der Kraan, Ineke, van Steense, Bas, van Driel, Roel, de Jong, Luitzen

“…Several nuclear activities and components are concentrated in discrete nuclear compartments. To understand the functional significance of nuclear…”
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Structure, Subnuclear Distribution, and Nuclear Matrix Association of the Mammalian Telomeric Complex by M. E. Eva Ludérus, van Steensel, Bas, Chong, Laura, Ody C. M. Sibon, Fons F. M. Cremers, de Lange, Titia

“…Mammalian telomeres are composed of long arrays of TTAGGG repeats complexed with the TTAGGG repeat binding factor, TRF. Biochemical and ultrastructural data…”
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Mechanisms and dynamics of nuclear lamina–genome interactions by Amendola, Mario, van Steensel, Bas

“…The nuclear lamina (NL) interacts with the genomic DNA and is thought to influence chromosome organization and gene expression. Both DNA sequences and histone…”
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Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence by Meuleman, Wouter, Peric-Hupkes, Daan, Kind, Jop, Beaudry, Jean-Bernard, Pagie, Ludo, Kellis, Manolis, Reinders, Marcel, Wessels, Lodewyk, van Steensel, Bas

“…In metazoans, the nuclear lamina is thought to play an important role in the spatial organization of interphase chromosomes, by providing anchoring sites for…”
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Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance by Schep, Ruben, Brinkman, Eva K., Leemans, Christ, Vergara, Xabier, van der Weide, Robin H., Morris, Ben, van Schaik, Tom, Manzo, Stefano G., Peric-Hupkes, Daniel, van den Berg, Jeroen, Beijersbergen, Roderick L., Medema, René H., van Steensel, Bas

“…DNA double-strand break (DSB) repair is mediated by multiple pathways. It is thought that the local chromatin context affects the pathway choice, but the…”
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Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells by Kind, Jop, Pagie, Ludo, de Vries, Sandra S., Nahidiazar, Leila, Dey, Siddharth S., Bienko, Magda, Zhan, Ye, Lajoie, Bryan, de Graaf, Carolyn A., Amendola, Mario, Fudenberg, Geoffrey, Imakaev, Maxim, Mirny, Leonid A., Jalink, Kees, Dekker, Job, van Oudenaarden, Alexander, van Steensel, Bas

“…Mammalian interphase chromosomes interact with the nuclear lamina (NL) through hundreds of large lamina-associated domains (LADs). We report a method to map NL…”
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Identification of in vivo DNA targets of chromatin proteins using tethered Dam methyltransferase by Steensel, Bas van, Henikoff, Steven

“…We have developed a novel technique, named DamID, for the identification of DNA loci that interact in vivo with specific nuclear proteins in eukaryotes. By…”
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Mapping of genetic and epigenetic regulatory networks using microarrays by van Steensel, Bas

“…The highly coordinated expression of thousands of genes in an organism is regulated by the concerted action of hundreds of transcription factors and chromatin…”
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TRF2 Protects Human Telomeres from End-to-End Fusions by van Steensel, Bas, Smogorzewska, Agata, de Lange, Titia

“…The mechanism by which telomeres prevent end-to-end fusion has remained elusive. Here, we show that the human telomeric protein TRF2 plays a key role in the…”
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Genome-wide HP1 binding in Drosophila: developmental plasticity and genomic targeting signals by de Wit, Elzo, Greil, Frauke, van Steensel, Bas

“…Heterochromatin protein 1 (HP1) is a major component of heterochromatin. It was reported to bind to a large number of genes and to many, but not all,…”
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Protocol: A Multiplexed Reporter Assay to Study Effects of Chromatin Context on DNA Double-Strand Break Repair by Schep, Ruben, Leemans, Christ, Brinkman, Eva K, van Schaik, Tom, van Steensel, Bas

“…DNA double-strand breaks (DSBs) can be repaired through various pathways. Understanding how these pathways are regulated is of great interest for cancer…”
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Control of telomere length by the human telomeric protein TRF1 by van Steensel, Bas, de Lange, Titia

“…Human telomeres, the nucleoprotein complexes at chromosome ends, consist of tandem arrays of TTAGGG repeats bound to specific proteins. In normal human cells,…”
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Chromatin profiling using targeted DNA adenine methyltransferase by van Steensel, Bas, Delrow, Jeffrey, Henikoff, Steven

“…Chromatin is the highly complex structure consisting of DNA and hundreds of associated proteins. Most chromatin proteins exert their regulatory and structural…”
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Chromosome-wide gene-specific targeting of the Drosophila dosage compensation complex by Gilfillan, Gregor D, Straub, Tobias, de Wit, Elzo, Greil, Frauke, Lamm, Rosemarie, van Steensel, Bas, Becker, Peter B

“…The dosage compensation complex (DCC) of Drosophila melanogaster is capable of distinguishing the single male X from the other chromosomes in the nucleus. It…”
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Control of Human Telomere Length by TRF1 and TRF2 by Smogorzewska, Agata, van Steensel, Bas, Bianchi, Alessandro, Oelmann, Stefan, Schaefer, Matthias R., Schnapp, Gisela, de Lange, Titia

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Genome-wide DNA replication profile for Drosophila melanogaster : a link between transcription and replication timing by Schübeler, Dirk, Groudine, Mark, Scalzo, David, Kooperberg, Charles, van Steensel, Bas, Delrow, Jeffrey

“…Replication of the genome before mitotic cell division is a highly regulated process that ensures the fidelity of DNA duplication. DNA replication initiates at…”
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