Search Results - "van Steeg, T J"

Effect of altered AGP plasma binding on heart rate changes by S(-)-propranolol in rats using mechanism-based estimations of in vivo receptor affinity (K(B,vivo)) by van Steeg, T J, Krekels, E H J, Freijer, J, Danhof, M, de Lange, E C M

“…In contrast to the impact of plasma protein binding on pharmacokinetics, no quantitative in vivo information is available on its impact on pharmacodynamics…”
Get more information

Cutaneous side-effects of transdermal iontophoresis with and without surfactant pretreatment: a single-blinded, randomized controlled trial by Li, G.L., Van Steeg, T.J., Putter, H., Van Der Spek, J., Pavel, S., Danhof, M., Bouwstra, J.A.

“…Summary Background  Iontophoresis, a method that facilitates drug transport across skin by an external electrical field, offers the possibility for long‐term…”
Get full text

Transdermal iontophoretic delivery of apomorphine in patients improved by surfactant formulation pretreatment by Li, G.L., de Vries, J.J., van Steeg, T.J., van den Bussche, H., Maas, H.J., Reeuwijk, H.J.E.M., Danhof, M., Bouwstra, J.A., van Laar, T.

“…The objective of the present study is to evaluate the efficacy and the safety of transdermal iontophoretic delivery of R-apomorphine, a potent dopamine…”
Get full text

Influence of plasma protein binding on pharmacodynamics: Estimation of in vivo receptor affinities of beta blockers using a new mechanism-based PK-PD modelling approach by van Steeg, T J, Boralli, V B, Krekels, E H J, Slijkerman, P, Freijer, J, Danhof, M, de Lange, E C M

“…The objective of this investigation was to examine in a systematic manner the influence of plasma protein binding on in vivo pharmacodynamics. Comparative…”
Get more information

Pharmacokinetic‐pharmacodynamic modelling of S(−)‐atenolol in rats: reduction of isoprenaline‐induced tachycardia as a continuous pharmacodynamic endpoint by Steeg, T J, Freijer, J, Danhof, M, Lange, E C M

“…Background and purpose: For development of mechanism‐based pharmacokinetic‐pharmacodynamic (PK‐PD) models, continuous recording of drug effects is essential…”
Get full text

Toward the prediction of CNS drug-effect profiles in physiological and pathological conditions using microdialysis and mechanism-based pharmacokinetic-pharmacodynamic modeling by de Lange, Elizabeth C M, Ravenstijn, Paulien G M, Groenendaal, Dorien, van Steeg, Tamara J

“…Our ultimate goal is to develop mechanism-based pharmacokinetic (PK)-pharmacodynamic (PD) models to characterize and to predict CNS drug responses in both…”
Get full text

ORIGINAL ARTICLE: Cutaneous side-effects of transdermal iontophoresis with and without surfactant pretreatment: a single-blinded, randomized controlled trial by Li, G L, Van Steeg, TJ, Putter, H, Van Der Spek, J, Pavel, S, Danhof, M, Bouwstra, JA

“…Background: Iontophoresis, a method that facilitates drug transport across skin by an external electrical field, offers the possibility for long-term…”
Get full text