Search Results - "van Steeg, Harry"

Chronically Alternating Light Cycles Increase Breast Cancer Risk in Mice by Van Dycke, Kirsten C.G., Rodenburg, Wendy, van Oostrom, Conny T.M., van Kerkhof, Linda W.M., Pennings, Jeroen L.A., Roenneberg, Till, van Steeg, Harry, van der Horst, Gijsbertus T.J.

“…Although epidemiological studies in shift workers and flight attendants have associated chronic circadian rhythm disturbance (CRD) with increased breast cancer…”
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The role of XPC: Implications in cancer and oxidative DNA damage by Melis, Joost P.M., Luijten, Mirjam, Mullenders, Leon H.F., van Steeg, Harry

“…The accumulation of DNA damage is a slow but hazardous phenomenon that may lead to cell death, accelerated aging features and cancer. One of the most versatile…”
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The Relationship Between Shift Work and Metabolic Risk Factors by Proper, Karin I., PhD, van de Langenberg, Daniëlla, MSc, Rodenburg, Wendy, PhD, Vermeulen, Roel C.H., PhD, van der Beek, Allard J., PhD, van Steeg, Harry, PhD, van Kerkhof, Linda W.M., PhD

“…Context Although the metabolic health effects of shift work have been extensively studied, a systematic synthesis of the available research is lacking. This…”
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An Xpb Mouse Model for Combined Xeroderma Pigmentosum and Cockayne Syndrome Reveals Progeroid Features upon Further Attenuation of DNA Repair by Andressoo, Jaan-Olle, Weeda, Geert, de Wit, Jan, Mitchell, James R., Beems, Rudolf B., van Steeg, Harry, van der Horst, Gijsbertus T. J., Hoeijmakers, Jan H.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA by Demaria, Marco, Ohtani, Naoko, Youssef, Sameh A., Rodier, Francis, Toussaint, Wendy, Mitchell, James R., Laberge, Remi-Martin, Vijg, Jan, Van Steeg, Harry, Dollé, Martijn E.T., Hoeijmakers, Jan H.J., de Bruin, Alain, Hara, Eiji, Campisi, Judith

“…Cellular senescence suppresses cancer by halting the growth of premalignant cells, yet the accumulation of senescent cells is thought to drive age-related…”
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Aging and Genome Maintenance: Lessons from the Mouse? by Hasty, Paul, Campisi, Judith, Hoeijmakers, Jan, van Steeg, Harry, Vijg, Jan

“…Recent progress in the science of aging is driven largely by the use of model systems, ranging from yeast and nematodes to mice. These models have revealed…”
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Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach by Hernández, Lya G., van Steeg, Harry, Luijten, Mirjam, van Benthem, Jan

“…It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these…”
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Protein and calorie restriction may improve outcomes in living kidney donors and kidney transplant recipients by Jongbloed, Franny, de Bruin, Ron W F, Steeg, Harry Van, Beekhof, Piet, Wackers, Paul, Hesselink, Dennis A, Hoeijmakers, Jan H J, Dollé, Martijn E T, IJzermans, Jan N M

“…Previously, we and others showed that dietary restriction protects against renal ischemia-reperfusion injury in animals. However, clinical translation of…”
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Impact of Simulated Rotating Shift Work on Mammary Tumor Development in the p53R270H©/+ WAPCre Mouse Model for Breast Cancer by Streng, Astrid A., Van Dycke, Kirsten C. G., van Oostrom, Conny T. M., Salvatori, Daniela C. F., Hulsegge, Gerben, Chaves, Inês, Roenneberg, Till, Zander, Serge A. L., van Steeg, Harry, van der Horst, Gijsbertus T. J., van Kerkhof, Linda W. M.

“…Epidemiological studies associate night shift work with increased breast cancer risk. However, the underlying mechanisms are not clearly understood. To better…”
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Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice by Birkisdóttir, María B., Jaarsma, Dick, Brandt, Renata M. C., Barnhoorn, Sander, Vliet, Nicole, Imholz, Sandra, Oostrom, Conny T., Nagarajah, Bhawani, Portilla Fernández, Eliana, Roks, Anton J. M., Elgersma, Ype, Steeg, Harry, Ferreira, José A., Pennings, Jeroen L. A., Hoeijmakers, Jan H. J., Vermeij, Wilbert P., Dollé, Martijn E. T.

“…Dietary restriction (DR) and rapamycin extend healthspan and life span across multiple species. We have recently shown that DR in progeroid DNA…”
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Comparison of clastogen-induced gene expression profiles in wild-type and DNA repair-deficient Rad54/Rad54B cells by Mahabir, Anuska G, Schaap, Mirjam M, Pennings, Jeroen L A, van Benthem, Jan, Hendriksen, Coenraad F M, van Steeg, Harry

“…Previously we found that Rad54/Rad54B cells are more sensitive towards mitomycin C (MMC) as compared to wild-type (WT) cells. This difference in sensitivity…”
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Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging by Kamenisch, York, Fousteri, Maria, Knoch, Jennifer, von Thaler, Anna-Katharina, Fehrenbacher, Birgit, Kato, Hiroki, Becker, Thomas, Dollé, Martijn E T, Kuiper, Raoul, Majora, Marc, Schaller, Martin, van der Horst, Gijsbertus T J, van Steeg, Harry, Röcken, Martin, Rapaport, Doron, Krutmann, Jean, Mullenders, Leon H, Berneburg, Mark

“…Defects in the DNA repair mechanism nucleotide excision repair (NER) may lead to tumors in xeroderma pigmentosum (XP) or to premature aging with loss of…”
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Time-restricted feeding improves adaptation to chronically alternating light-dark cycles by Schilperoort, Maaike, van den Berg, Rosa, Dollé, Martijn E. T., van Oostrom, Conny T. M., Wagner, Karina, Tambyrajah, Lauren L., Wackers, Paul, Deboer, Tom, Hulsegge, Gerben, Proper, Karin I., van Steeg, Harry, Roenneberg, Till, Biermasz, Nienke R., Rensen, Patrick C. N., Kooijman, Sander, van Kerkhof, Linda W. M.

“…Disturbance of the circadian clock has been associated with increased risk of cardio-metabolic disorders. Previous studies showed that optimal timing of food…”
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Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair by Schwarz, Agatha, Maeda, Akira, Kernebeck, Kerstin, van Steeg, Harry, Beissert, Stefan, Schwarz, Thomas

“…The immunostimulatory cytokine IL-12 is able to antagonize immunosuppression induced by solar/ultraviolet (UV) radiation via yet unknown mechanisms. IL-12 was…”
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Diurnal Variation of Hormonal and Lipid Biomarkers in a Molecular Epidemiology-Like Setting by van Kerkhof, Linda W M, Van Dycke, Kirsten C G, Jansen, Eugene H J M, Beekhof, Piet K, van Oostrom, Conny T M, Ruskovska, Tatjana, Velickova, Nevenka, Kamcev, Nikola, Pennings, Jeroen L A, van Steeg, Harry, Rodenburg, Wendy

“…Many molecular epidemiology studies focusing on high prevalent diseases, such as metabolic disorders and cancer, investigate metabolic and hormonal markers. In…”
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Green tea polyphenols prevent UV-induced immunosuppression by rapid repair of DNA damage and enhancement of nucleotide excision repair genes by Katiyar, Santosh K, Vaid, Mudit, van Steeg, Harry, Meeran, Syed M

“…UV radiation-induced immunosuppression has been implicated in the development of skin cancers. Green tea polyphenols (GTP) in drinking water prevent…”
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Correction to: Toxicogenomics directory of chemically exposed human hepatocytes by Grinberg, Marianna, Stöber, Regina M., Edlund, Karolina, Rempel, Eugen, Godoy, Patricio, Reif, Raymond, Widera, Agata, Madjar, Katrin, Schmidt-Heck, Wolfgang, Marchan, Rosemarie, Sachinidis, Agapios, Spitkovsky, Dimitry, Hescheler, Jürgen, Carmo, Helena, Arbo, Marcelo D., van de Water, Bob, Wink, Steven, Vinken, Mathieu, Rogiers, Vera, Escher, Sylvia, Hardy, Barry, Mitic, Dragana, Apic, Gordana, Myatt, Glenn, Waldmann, Tanja, Mardinoglu, Adil, Damm, Georg, Seehofer, Daniel, Nüssler, Andreas, Weiss, Thomas S., Oberemm, Axel, Lampen, ·Alfons, Schaap, Mirjam M., Luijten, Mirjam, van Steeg, Harry, Thasler, Wolfgang E., Kleinjans, Jos C. S., Stierum, Rob H., Leist, ·Marcel, Rahnenführer, Jörg, Hengstler, Jan G.

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Delayed and accelerated aging share common longevity assurance mechanisms by Schumacher, Björn, van der Pluijm, Ingrid, Moorhouse, Michael J, Kosteas, Theodore, Robinson, Andria Rasile, Suh, Yousin, Breit, Timo M, van Steeg, Harry, Niedernhofer, Laura J, van Ijcken, Wilfred, Bartke, Andrzej, Spindler, Stephen R, Hoeijmakers, Jan H J, van der Horst, Gijsbertus T J, Garinis, George A

“…Mutant dwarf and calorie-restricted mice benefit from healthy aging and unusually long lifespan. In contrast, mouse models for DNA repair-deficient progeroid…”
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A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens by Schaap, Mirjam M., Wackers, Paul F. K., Zwart, Edwin P., Huijskens, Ilse, Jonker, Martijs J., Hendriks, Giel, Breit, Timo M., van Steeg, Harry, van de Water, Bob, Luijten, Mirjam

“…Alternative methods to detect non-genotoxic carcinogens are urgently needed, as this class of carcinogens goes undetected in the current testing strategy for…”
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The transcriptomic response to irinotecan in colon carcinoma bearing mice preconditioned by fasting by Jongbloed, Franny, Huisman, Sander A, van Steeg, Harry, Pennings, Jeroen L A, IJzermans, Jan N M, Dollé, Martijn E T, de Bruin, Ron W F

“…Irinotecan use is limited due to severe toxicity. Preconditioning by fasting (PBF) protects against side effects of irinotecan while preserving its antitumor…”
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