Search Results - "van Scheppingen, Wibo B"
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Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum
Published in Proceedings of the National Academy of Sciences - PNAS (03-03-2015)“…The cholesterol-lowering blockbuster drug pravastatin can be produced by stereoselective hydroxylation of the natural product compactin. We report here the…”
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Detection of 4a,5-dihydropravastatin as Impurity in the Cholesterol Lowering Drug Pravastatin
Published in Molecules (Basel, Switzerland) (03-08-2021)“…Dihydro analogues are known byproducts of the fermentative production of statins and cannot be detected with existing pharmacopoeia analysis methods. We…”
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Thermal Stability of 2,2,6,6-Tetramethylpiperidine-1-oxyl (TEMPO) and Related N-Alkoxyamines
Published in Journal of the American Chemical Society (14-07-1999)“…The carbon−oxygen bond dissociation enthalpies, BDE(C−O), in several N-alkoxyamine derivatives based on 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) have been…”
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Selective and sensitive determination of lactose in low-lactose dairy products with HPAEC-PAD
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15-08-2017)“…•Determination of low lactose (<0.01%) in wide range of dairy products.•Simple sample preparation steps, i.e. dilution, centrifugation and…”
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Study on decomposition products of norbixin during bleaching with hydrogen peroxide and a peroxidase by means of UPLC-UV and mass spectrometry
Published in Food chemistry (01-06-2012)“…► Under bleaching conditions, unsaturated aldehydes and ketones are formed as decomposition products of norbixin. ► A reaction scheme for the decomposition of…”
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Thermal Hydrogenolysis of Polyaromatic Hydrocarbons and Activated Carbon at Elevated Temperatures and Pressures
Published in European journal of organic chemistry (01-12-2001)“…Vaporised polyaromatic hydrocarbons (indene, naphthalene, biphenyl, phenanthrene, anthracene) admixed with benzene, have been processed in flow reactors at…”
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Gas-Phase Hydrogenolysis of Benzene and Derivatives at Elevated Pressure; Methane Formation
Published in European journal of organic chemistry (01-06-2001)“…Benzene, in 20−30 bar of hydrogen, reacts smoothly in a quartz tubular flow reactor between 1163−1262 K, to give high yields of methane. With dwell times of…”
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8
Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming ofPenicillium chrysogenum
Published in Proceedings of the National Academy of Sciences - PNAS (03-03-2015)“…The cholesterol-lowering blockbuster drug pravastatin can be produced by stereoselective hydroxylation of the natural product compactin. We report here the…”
Get full text
Journal Article