Search Results - "van Ry, Tyler"
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Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis
Published in eLife (14-08-2020)“…Brown adipose tissue (BAT) is composed of thermogenic cells that convert chemical energy into heat to maintain a constant body temperature and counteract…”
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Metabolic reprogramming of the myeloid lineage by Schistosoma mansoni infection persists independently of antigen exposure
Published in PLoS pathogens (08-01-2021)“…Macrophages have a defined role in the pathogenesis of metabolic disease and cholesterol metabolism where alternative activation of macrophages is thought to…”
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Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance
Published in Cell (04-04-2019)“…Host defenses against pathogens are energetically expensive, leading ecological immunologists to postulate that they might participate in energetic trade-offs…”
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The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure
Published in Cell metabolism (02-03-2021)“…The metabolic rewiring of cardiomyocytes is a widely accepted hallmark of heart failure (HF). These metabolic changes include a decrease in mitochondrial…”
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An evolutionary trade-off between host immunity and metabolism drives fatty liver in male mice
Published in Science (American Association for the Advancement of Science) (21-10-2022)“…Adaptations to infectious and dietary pressures shape mammalian physiology and disease risk. How such adaptations affect sex-biased diseases remains…”
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SU9516 Increases α7β1 Integrin and Ameliorates Disease Progression in the mdx Mouse Model of Duchenne Muscular Dystrophy
Published in Molecular therapy (07-06-2017)“…Duchenne muscular dystrophy (DMD) is a fatal muscle disease caused by mutations in the dystrophin gene, resulting in a complete loss of the dystrophin protein…”
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Metaboverse enables automated discovery and visualization of diverse metabolic regulatory patterns
Published in Nature cell biology (01-04-2023)“…Metabolism is intertwined with various cellular processes, including controlling cell fate, influencing tumorigenesis, participating in stress responses and…”
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