Search Results - "van Rijswijck, Danique M H"
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Antigen-specific Fab profiling achieves molecular-resolution analysis of human autoantibody repertoires in rheumatoid arthritis
Published in Nature communications (10-04-2024)“…The presence of autoantibodies is a defining feature of many autoimmune diseases. The number of unique autoantibody clones is conceivably limited by immune…”
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Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern
Published in Nature communications (15-10-2022)“…Existing assays to measure antibody cross-reactivity against different SARS-CoV-2 spike (S) protein variants lack the discriminatory power to provide insights…”
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A Direct MS-Based Approach to Profile Human Milk Secretory Immunoglobulin A (IgA1) Reveals Donor-Specific Clonal Repertoires With High Longitudinal Stability
Published in Frontiers in immunology (06-12-2021)“…Recently, a mass spectrometry-based approach was introduced to directly assess the IgG1 immunoglobulin clonal repertoires in plasma. Here we expanded upon this…”
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A case series exploring the human milk polyclonal IgA1 response to repeated SARS-CoV-2 vaccinations by LC-MS based fab profiling
Published in Frontiers in nutrition (Lausanne) (15-01-2024)“…Upon vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) humans will start to produce antibodies targeting virus specific antigens…”
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Direct Comparison of the Hinge-Cleaving Proteases IgdE and BdpK for LC-MS-Based IgG1 Clonal Profiling
Published in Analytical chemistry (Washington) (09-01-2024)“…Human antibodies are heterogeneous molecules primarily due to clonal sequence variations. Analytical techniques to assess antibody levels quantitatively, such…”
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Into the Dark Serum Proteome: Personalized Features of IgG1 and IgA1 Repertoires in Severe COVID-19 Patients
Published in Molecular & cellular proteomics (01-01-2024)“…Serum proteomics has matured and is now able to monitor hundreds of proteins quantitatively in large cohorts of patients. However, the fine characteristics of…”
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Affimers as an alternative to antibodies for protein biomarker enrichment
Published in Protein expression and purification (01-10-2020)“…Assessing the specificity of protein binders is an essential first step in protein biomarker assay development. Affimers are novel protein binders and can…”
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