Search Results - "van Rijssel, Erwin R"

Furanosyl Oxocarbenium Ion Conformational Energy Landscape Maps as a Tool to Study the Glycosylation Stereoselectivity of 2‐Azidofuranoses, 2‐Fluorofuranoses and Methyl Furanosyl Uronates by van der Vorm, Stefan, Hansen, Thomas, van Rijssel, Erwin R., Dekkers, Rolf, Madern, Jerre M., Overkleeft, Herman S., Filippov, Dmitri V., van der Marel, Gijsbert A., Codée, Jeroen D. C.

“…The 3D shape of glycosyl oxocarbenium ions determines their stability and reactivity and the stereochemical course of SN1 reactions taking place on these…”
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Synthesis and Evaluation of Hybrid Structures Composed of Two Glucosylceramide Synthase Inhibitors by van den Berg, Richard J. B. H. N., van Rijssel, Erwin R., Ferraz, Maria Joao, Houben, Judith, Strijland, Anneke, Donker-Koopman, Wilma E., Wennekes, Tom, Bonger, Kimberly M., Ghisaidoobe, Amar B. T., Hoogendoorn, Sascha, van der Marel, Gijsbert A., Codée, Jeroen D. C., Overkleeft, Herman S., Aerts, Johannes M. F. G.

“…Glucosylceramide metabolism and the enzymes involved have attracted significant interest in medicinal chemistry, because aberrations in the levels of…”
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Furanosyl Oxocarbenium Ion Stability and Stereoselectivity by van Rijssel, Erwin R., van Delft, Pieter, Lodder, Gerrit, Overkleeft, Herman S., van der Marel, Gijsbert A., Filippov, Dmitri V., Codée, Jeroen D. C.

“…Lewis acid mediated substitution reactions using [D]triethylsilane as a nucleophile at the anomeric center of the four pentofuranoses, ribose, arabinose,…”
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Acceptor Reactivity in the Total Synthesis of Alginate Fragments Containing α-L-Guluronic Acid and β-D-Mannuronic Acid by Zhang, Qingju, van Rijssel, Erwin R., Walvoort, Marthe T. C., Overkleeft, Herman S., van der Marel, Gijsbert A., Codée, Jeroen D. C.

“…The total synthesis of mixed‐sequence alginate oligosaccharides, featuring both β‐D‐mannuronic acid (M) and α‐L‐guluronic acid (G), is reported for the first…”
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Conformational Behaviour of Azasugars Based on Mannuronic Acid by van Rijssel, Erwin R., Janssen, Antonius P. A., Males, Alexandra, Davies, Gideon J., van der Marel, Gijsbert A., Overkleeft, Herman S., Codée, Jeroen D. C.

“…A set of mannuronic‐acid‐based iminosugars, consisting of the C‐5‐carboxylic acid, methyl ester and amide analogues of 1deoxymannorjirimicin (DMJ), was…”
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Manno-epi-cyclophellitols Enable Activity-Based Protein Profiling of Human α‑Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors by Armstrong, Zachary, Kuo, Chi-Lin, Lahav, Daniël, Liu, Bing, Johnson, Rachel, Beenakker, Thomas J. M, de Boer, Casper, Wong, Chung-Sing, van Rijssel, Erwin R, Debets, Marjoke F, Florea, Bogdan I, Hissink, Colin, Boot, Rolf G, Geurink, Paul P, Ovaa, Huib, van der Stelt, Mario, van der Marel, Gijsbert M, Codée, Jeroen D. C, Aerts, Johannes M. F. G, Wu, Liang, Overkleeft, Herman S, Davies, Gideon J

“…Golgi mannosidase II (GMII) catalyzes the sequential hydrolysis of two mannosyl residues from GlcNAcMan5GlcNAc2 to produce GlcNAcMan3GlcNAc2, the precursor for…”
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Synthesis, Reactivity, and Stereoselectivity of 4‑Thiofuranosides by Madern, Jerre M, Hansen, Thomas, van Rijssel, Erwin R, Kistemaker, Hans A.V, van der Vorm, Stefan, Overkleeft, Herman S, van der Marel, Gijsbert A, Filippov, Dmitri V, Codée, Jeroen D.C

“…Thiosugars, sugars that have their endocyclic oxygen substituted for a sulfur atom, have been used as stable bioisosteres of naturally occurring glycans…”
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Carba-cyclophellitols Are Neutral Retaining-Glucosidase Inhibitors by Beenakker, Thomas J. M, Wander, Dennis P. A, Offen, Wendy A, Artola, Marta, Raich, Lluís, Ferraz, Maria J, Li, Kah-Yee, Houben, Judith H. P. M, van Rijssel, Erwin R, Hansen, Thomas, van der Marel, Gijsbert A, Codée, Jeroen D. C, Aerts, Johannes M. F. G, Rovira, Carme, Davies, Gideon J, Overkleeft, Herman S

“…The conformational analysis of glycosidases affords a route to their specific inhibition through transition-state mimicry. Inspired by the rapid reaction rates…”
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Stereoselectivity in the Lewis Acid Mediated Reduction of Ketofuranoses by van Rijssel, Erwin R, van Delft, Pieter, van Marle, Daan V, Bijvoets, Stefan M, Lodder, Gerrit, Overkleeft, Herman S, van der Marel, Gijsbert A, Filippov, Dmitri V, Codée, Jeroen D. C

“…The Lewis acid mediated reduction of ribose-, arabinose-, xylose-, and lyxose-derived methyl and phenyl ketofuranoses with triethylsilane as nucleophile was…”
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Potent and Selective Activity-Based Probes for GH27 Human Retaining α‑Galactosidases by Willems, Lianne I, Beenakker, Thomas J. M, Murray, Benjamin, Scheij, Saskia, Kallemeijn, Wouter W, Boot, Rolf G, Verhoek, Marri, Donker-Koopman, Wilma E, Ferraz, Maria J, van Rijssel, Erwin R, Florea, Bogdan I, Codée, Jeroen D. C, van der Marel, Gijsbert A, Aerts, Johannes M. F. G, Overkleeft, Herman S

“…Lysosomal degradation of glycosphingolipids is mediated by the consecutive action of several glycosidases. Malfunctioning of one of these hydrolases can lead…”
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On the Reactivity of Gulose and Guluronic Acid Building Blocks in the Context of Alginate Assembly by Zhang, Qingju, van Rijssel, Erwin R., Overkleeft, Herman S., van der Marel, Gijsbert A., Codée, Jeroen D. C.

“…A novel set of L‐gulose and L‐guluronic acid building blocks, comprising both monosaccharide and disaccharide synthons, was assembled to investigate how…”
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Chiral Pyrroline-Based Ugi-Three-Component Reactions Are under Kinetic Control by van Rijssel, Erwin R, Goumans, Theodorus P. M, Lodder, Gerrit, Overkleeft, Herman S, van der Marel, Gijsbert A, Codée, Jeroen D. C

“…Although it is often assumed that the stereochemistry in Ugi multicomponent reactions is determined in the final Mumm rearrangement step, experimental and…”
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Acceptor Reactivity in the Total Synthesis of Alginate Fragments Containing [alpha]-L-Guluronic Acid and [beta]-D-Mannuronic Acid by Zhang, Qingju, vanRijssel, Erwin R, Walvoort, Marthe T C, Overkleeft, Herman S, vanderMarel, Gijsbert A, Codee, Jeroen D C

“…The total synthesis of mixed-sequence alginate oligosaccharides, featuring both [beta]-D-mannuronic acid (M) and [alpha]-L-guluronic acid (G), is reported for…”
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Cover Feature: Furanosyl Oxocarbenium Ion Conformational Energy Landscape Maps as a Tool to Study the Glycosylation Stereoselectivity of 2‐Azidofuranoses, 2‐Fluorofuranoses and Methyl Furanosyl Uronates (Chem. Eur. J. 29/2019) by van der Vorm, Stefan, Hansen, Thomas, van Rijssel, Erwin R., Dekkers, Rolf, Madern, Jerre M., Overkleeft, Herman S., Filippov, Dmitri V., van der Marel, Gijsbert A., Codée, Jeroen D. C.

“…Energy maps of the full conformational space of 5‐membered ring glycosyl oxocarbenium ions have been generated to probe the stereoelectronic effects of…”
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Synthesis of α- and β-Galactopyranose-Configured Isomers of Cyclophellitol and Cyclophellitol Aziridine by Willems, Lianne I., Beenakker, Thomas J. M., Murray, Benjamin, Gagestein, Berend, van den Elst, Hans, van Rijssel, Erwin R., Codée, Jeroen D. C., Kallemeijn, Wouter W., Aerts, Johannes M. F. G., van der Marel, Gijsbert A., Overkleeft, Herman S.

“…Cyclophellitol and cyclophellitol aziridine are potent and irreversible mechanism‐based inhibitors of retaining β‐glucosidases. Alterations in the…”
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Synthesis of [alpha]- and [beta]-Galactopyranose-Configured Isomers of Cyclophellitol and Cyclophellitol Aziridine by Willems, Lianne I, Beenakker, Thomas J M, Murray, Benjamin, Gagestein, Berend, van den Elst, Hans, van Rijssel, Erwin R, Codee, Jeroen D C, Kallemeijn, Wouter W, Aerts, Johannes M F G, van der Marel, Gijsbert A, Overkleeft, Herman S

“…Cyclophellitol and cyclophellitol aziridine are potent and irreversible mechanism-based inhibitors of retaining [beta]-glucosidases. Alterations in the…”
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Acceptor Reactivity in the Total Synthesis of Alginate Fragments Containing α-L-Guluronic Acid and β-D-Mannuronic Acid by Zhang, Qingju, van Rijssel, Erwin R., Walvoort, Marthe T. C., Overkleeft, Herman S., van der Marel, Gijsbert A., Codée, Jeroen D. C.

“…The total synthesis of mixed‐sequence alginate oligosaccharides, featuring both β‐D‐mannuronic acid (M) and α‐L‐guluronic acid (G), is reported for the first…”
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Furanosyl Oxocarbenium Ion Stability and Stereoselectivity by van Rijssel, Erwin R., van Delft, Pieter, Lodder, Gerrit, Overkleeft, Herman S., van der Marel, Gijsbert A., Filippov, Dmitri V., Codée, Jeroen D. C.

“…Lewis acid mediated substitution reactions using [D]triethylsilane as a nucleophile at the anomeric center of the four pentofuranoses, ribose, arabinose,…”
Get full text