The role of computational models in the search for the mechanical behavior and damage mechanisms of articular cartilage

The role of computational models in the search for the mechanical behavior and damage mechanisms of articular cartilage

Articular cartilage plays a vital role in the function of diarthrodial joints. Due to osteoarthritis degeneration of articular cartilage occurs. The initial event that triggers the pathological process of cartilage degeneration is still unknown. Cartilage damage due to osteoarthritis is believed to...

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Bibliographic Details
Published in:Medical engineering & physics Vol. 27; no. 10; pp. 810 - 826
Main Authors: Wilson, W., van Donkelaar, C.C., van Rietbergen, R., Huiskes, R.
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-12-2005
Subjects:
Animals
Anisotropy
Biomechanical Phenomena
Biophysics - methods
Cartilage
Cartilage - chemistry
Cartilage - pathology
Cartilage, Articular - cytology
Chondrocytes - cytology
Chondrocytes - metabolism
Collagen
Collagen - chemistry
Compressive Strength
Computational Biology - methods
Damage
Elasticity
Electrochemistry
Finite Element Analysis
Humans
Knee Joint
Models, Biological
Models, Genetic
Models, Statistical
Osmosis
Osteoarthritis - metabolism
Proteoglycans - metabolism
Software
Stress, Mechanical
Swelling
Tensile Strength
Cartilage
AC
OA
FEA
Swelling
FCD
Collagen
PG
Finite element analysis
Damage
AGE
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Summary:Articular cartilage plays a vital role in the function of diarthrodial joints. Due to osteoarthritis degeneration of articular cartilage occurs. The initial event that triggers the pathological process of cartilage degeneration is still unknown. Cartilage damage due to osteoarthritis is believed to be mechanically induced. Hence, to investigate the initiation of osteoarthritis the stresses and strains in the cartilage must be determined. So far the most common method to accomplish that is finite element analysis. This paper provides an overview of computational descriptions developed for this purpose, and what they can be used for. Articular cartilage composition and structure are discussed in relation with degenerative changes, and how these affect mechanical properties.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1350-4533
1873-4030
DOI:10.1016/j.medengphy.2005.03.004