Venous hypertension of the hand caused by hemodialysis shunt: immunofluorescence studies of pericapillary cuffs

Venous hypertension of the hand caused by hemodialysis shunt: immunofluorescence studies of pericapillary cuffs

Venous hypertension of the hand is an unusual complication of an arteriovenous shunt in patients receiving dialysis. We investigated whether in venous hypertension of the hand pericapillary cuffs are present and whether they consist of fibrin and other components. Biopsy specimens were taken from th...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology Vol. 31; no. 1; p. 23
Main Authors: Brakman, M, Faber, W R, Zeegelaar, J E, Bousema, M T, van Proosdij, J L, Kerckhaert, J A
Format: Journal Article
Language:English
Published: United States 01-07-1994
Subjects:
Adult
Aged
Arteriovenous Shunt, Surgical - adverse effects
Capillaries - chemistry
Collagen - analysis
Female
Fibrin - analysis
Fibrinogen - analysis
Fluorescent Antibody Technique
Hand - blood supply
Humans
Male
Middle Aged
Plasminogen Activator Inhibitor 1 - analysis
Renal Dialysis - adverse effects
Venous Pressure
von Willebrand Factor - analysis
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Summary:Venous hypertension of the hand is an unusual complication of an arteriovenous shunt in patients receiving dialysis. We investigated whether in venous hypertension of the hand pericapillary cuffs are present and whether they consist of fibrin and other components. Biopsy specimens were taken from three patients with a side-to-side shunt and venous hypertension of the hand, from three patients with an end-to-side shunt without venous hypertension, and from three control subjects. The specimens were stained with antibodies against fibrinogen, fibrin, plasminogen activator inhibitor-I, factor VIII-related antigen, and collagen type IV. Pericapillary cuffs consisting of fibrin only were observed in patients with venous hypertension of the hand. In this fibrin network, factor VIII-related antigen and collagen type IV were also present. The finding of plasminogen activator inhibitor-I in the pericapillary cuff in the patient with the most severe signs of venous hypertension may indicate that breakdown of this fibrin cuff is impaired. Pericapillary cuffs may be of pathogenetic significance in venous hypertension of the hand.
ISSN:0190-9622
DOI:10.1016/S0190-9622(94)70129-6